Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily
about
Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interactionThe junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilinThe Bcr kinase downregulates Ras signaling by phosphorylating AF-6 and binding to its PDZ domainDynamic properties of the Ras switch I region and its importance for binding to effectorsStructural Basis for Conformational Dynamics of GTP-bound Ras ProteinRYK, a catalytically inactive receptor tyrosine kinase, associates with EphB2 and EphB3 but does not interact with AF-6Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localizationRequirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesisAssociation rate constants of ras-effector interactions are evolutionarily conservedHigh-throughput immunoblotting identifies biotin-dependent signaling proteins in HepG2 hepatocarcinoma cells.Eph receptors and ephrin ligands: embryogenesis to tumorigenesis.AF-6 controls integrin-mediated cell adhesion by regulating Rap1 activation through the specific recruitment of Rap1GTP and SPA-1.Crystal structure of M-Ras reveals a GTP-bound "off" state conformation of Ras family small GTPases.AF6 negatively regulates Rap1-induced cell adhesion.The AF-6 homolog canoe acts as a Rap1 effector during dorsal closure of the Drosophila embryo.Distinct requirements for Ras oncogenesis in human versus mouse cells.Adherens junctions: new insight into assembly, modulation and function.Electrostatically optimized Ras-binding Ral guanine dissociation stimulator mutants increase the rate of association by stabilizing the encounter complexGenetic ablation of afadin causes mislocalization and deformation of Paneth cells in the mouse small intestinal epithelium.Discontinuities in Rap1 activity determine epithelial cell morphology within the developing wing of Drosophila.The RAS-Effector Interface: Isoform-Specific Differences in the Effector Binding RegionsThe small GTPase, Rap1, mediates CD31-induced integrin adhesion.Rap1 and Canoe/afadin are essential for establishment of apical-basal polarity in the Drosophila embryo.Junctional adhesion molecule A interacts with Afadin and PDZ-GEF2 to activate Rap1A, regulate beta1 integrin levels, and enhance cell migration.The Drosophila afadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constriction.Rap1 maintains adhesion between cells to affect Egfr signaling and planar cell polarity in DrosophilaStructural determinants of Junctional Adhesion Molecule A (JAM-A) function and mechanisms of intracellular signaling.The dual role of zonula occludens (ZO) proteins.Structures of Ras superfamily effector complexes: What have we learnt in two decades?Cooperative role of nectin-nectin and nectin-afadin interactions in formation of nectin-based cell-cell adhesion.Characterization of nectin processing mediated by presenilin-dependent γ-secretase.Lipopolysaccharide-induced activation of beta2-integrin function in macrophages requires Irak kinase activity, p38 mitogen- activated protein kinase, and the Rap1 GTPaseLoss of AF6/afadin, a marker of poor outcome in breast cancer, induces cell migration, invasiveness and tumor growth.Regulation of the assembly and adhesion activity of E-cadherin by nectin and afadin for the formation of adherens junctions in Madin-Darby canine kidney cells.Regulation of E-cadherin endocytosis by nectin through afadin, Rap1, and p120ctn.The cAMP-Epac-Rap1 pathway regulates cell spreading and cell adhesion to laminin-5 through the alpha3beta1 integrin but not the alpha6beta4 integrin.Activation of Ras-Ral pathway attenuates p53-independent DNA damage G2 checkpoint.GTK, a Src-related tyrosine kinase, induces nerve growth factor-independent neurite outgrowth in PC12 cells through activation of the Rap1 pathway. Relationship to Shb tyrosine phosphorylation and elevated levels of focal adhesion kinase.Signaling specificity by Ras family GTPases is determined by the full spectrum of effectors they regulate.Conformational states of human rat sarcoma (Ras) protein complexed with its natural ligand GTP and their role for effector interaction and GTP hydrolysis.
P2860
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P2860
Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily
description
1999 nî lūn-bûn
@nan
1999 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Thermodynamic and kinetic char ...... d members of the Ras subfamily
@ast
Thermodynamic and kinetic char ...... d members of the Ras subfamily
@en
Thermodynamic and kinetic char ...... d members of the Ras subfamily
@nl
type
label
Thermodynamic and kinetic char ...... d members of the Ras subfamily
@ast
Thermodynamic and kinetic char ...... d members of the Ras subfamily
@en
Thermodynamic and kinetic char ...... d members of the Ras subfamily
@nl
prefLabel
Thermodynamic and kinetic char ...... d members of the Ras subfamily
@ast
Thermodynamic and kinetic char ...... d members of the Ras subfamily
@en
Thermodynamic and kinetic char ...... d members of the Ras subfamily
@nl
P2093
P2860
P356
P1476
Thermodynamic and kinetic char ...... d members of the Ras subfamily
@en
P2093
A Wittinghofer
B K Jaitner
C Herrmann
T Linnemann
P2860
P304
13556-13562
P356
10.1074/JBC.274.19.13556
P407
P577
1999-05-01T00:00:00Z