Interaction of the antibiotics clindamycin and lincomycin with Escherichia coli 23S ribosomal RNA.
about
Antibiotics that target protein synthesisStructural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteriaChiral Alkyl Halides: Underexplored Motifs in MedicineMolecular mechanisms by which rRNA mutations confer resistance to clindamycinNew lnu(C) gene conferring resistance to lincomycin by nucleotidylation in Streptococcus agalactiae UCN36Spontaneous erythromycin resistance mutation in a 23S rRNA gene, rrlA, of the extreme thermophile Thermus thermophilus IB-21.Macrolide resistance conferred by base substitutions in 23S rRNA.Antibiotics that bind to the A site of the large ribosomal subunit can induce mRNA translocation.Resistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergy.In vitro assays elucidate peculiar kinetics of clindamycin action against Toxoplasma gondiiA spontaneous point mutation in the single 23S rRNA gene of the thermophilic arachaeon Sulfolobus acidocaldarius confers multiple drug resistanceAntibiotic drugs targeting bacterial RNAs.Species-specific antibiotic-ribosome interactions: implications for drug development.tISCpe8, an IS1595-family lincomycin resistance element located on a conjugative plasmid in Clostridium perfringens.Sorting Out Antibiotics' Mechanisms of Action: a Double Fluorescent Protein Reporter for High-Throughput Screening of Ribosome and DNA Biosynthesis InhibitorsA population genomics approach to exploiting the accessory 'resistome' of Escherichia coli.Activity of the ketolide telithromycin is refractory to Erm monomethylation of bacterial rRNA.Mutations in 23S rRNA account for intrinsic resistance to macrolides in Mycoplasma hominis and Mycoplasma fermentans and for acquired resistance to macrolides in M. hominis.Erythromycin resistance by ribosome modification.Transition mutations in the 23S rRNA of erythromycin-resistant isolates of Mycoplasma pneumoniae.The oxazolidinone eperezolid binds to the 50S ribosomal subunit and competes with binding of chloramphenicol and lincomycinRole for the highly conserved region of domain IV of 23S-like rRNA in subunit-subunit interactions at the peptidyl transferase centre.Short Proline-Rich Antimicrobial Peptides Inhibit Either the Bacterial 70S Ribosome or the Assembly of its Large 50S Subunit.Antibiotic inhibition of the movement of tRNA substrates through a peptidyl transferase cavity.Movement of the 3'-end of tRNA through the peptidyl transferase centre and its inhibition by antibiotics.The conformation of 23S rRNA nucleotide A2058 determines its recognition by the ErmE methyltransferase.Structural insights of lincosamides targeting the ribosome of Staphylococcus aureus.Ribosomal RNA is the target for oxazolidinones, a novel class of translational inhibitors.Peptidyl transferase antibiotics perturb the relative positioning of the 3'-terminal adenosine of P/P'-site-bound tRNA and 23S rRNA in the ribosome.An rRNA mutation identifies the apicoplast as the target for clindamycin in Toxoplasma gondii.Unraveling new features of clindamycin interaction with functional ribosomes and dependence of the drug potency on polyamines.
P2860
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P2860
Interaction of the antibiotics clindamycin and lincomycin with Escherichia coli 23S ribosomal RNA.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
Interaction of the antibiotics ...... richia coli 23S ribosomal RNA.
@en
type
label
Interaction of the antibiotics ...... richia coli 23S ribosomal RNA.
@en
prefLabel
Interaction of the antibiotics ...... richia coli 23S ribosomal RNA.
@en
P2860
P356
P1476
Interaction of the antibiotics ...... richia coli 23S ribosomal RNA.
@en
P2093
Douthwaite S
P2860
P304
P356
10.1093/NAR/20.18.4717
P577
1992-09-01T00:00:00Z