Telomeric recombination in mismatch repair deficient human colon cancer cells after telomerase inhibition.
about
DNA mismatch repair: molecular mechanism, cancer, and ageingTelomerase reverse transcriptase moonlights: Therapeutic targets beyond telomeraseThe role of RecQ helicases in non-homologous end-joiningToward a molecular classification of colorectal cancer: the role of telomere lengthCausal link between microsatellite instability and hMRE11 dysfunction in human cancersBalancing self-renewal against genome preservation in stem cells: How do they manage to have the cake and eat it too?Cell proliferation in the presence of telomeraseWRN loss induces switching of telomerase-independent mechanisms of telomere elongationElevated rates of sister chromatid exchange at chromosome ends.Human MLH1 suppresses the insertion of telomeric sequences at intra-chromosomal sites in telomerase-expressing cells.Alternative lengthening of telomeres can be maintained by preferential elongation of lagging strands.Relationship between telomere shortening, genetic instability, and site of tumour origin in colorectal cancers.An increase in telomere sister chromatid exchange in murine embryonic stem cells possessing critically shortened telomeres.Telomeric DNA in ALT cells is characterized by free telomeric circles and heterogeneous t-loopsTwisted epithelial-to-mesenchymal transition promotes progression of surviving bladder cancer T24 cells with hTERT-dysfunction.Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway.Regulatory roles of tankyrase 1 at telomeres and in DNA repair: suppression of T-SCE and stabilization of DNA-PKcs.Long telomeres produced by telomerase-resistant recombination are established from a single source and are subject to extreme sequence scramblingTelomeric recombination induced by dysfunctional telomeres.Induction of telomere dysfunction mediated by the telomerase substrate precursor 6-thio-2'-deoxyguanosine.Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis.Deficient mismatch repair improves organismal fitness and survival of mice with dysfunctional telomeresSuv4-20h deficiency results in telomere elongation and derepression of telomere recombinationTelomerase activity in colorectal cancer, prognostic factor and implications in the microsatellite instability pathway.Maintenance of very long telomeres by recombination in the Kluyveromyces lactis stn1-M1 mutant involves extreme telomeric turnover, telomeric circles, and concerted telomeric amplification.Differential requirements for DNA repair proteins in immortalized cell lines using alternative lengthening of telomere mechanisms.Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells.The roles of telomerase in the generation of polyploidy during neoplastic cell growth.Telomerase inhibition in cancer therapeutics: molecular-based approachesFrequent recombination in telomeric DNA may extend the proliferative life of telomerase-negative cellsTelomere targeting with a novel G-quadruplex-interactive ligand BRACO-19 induces T-loop disassembly and telomerase displacement in human glioblastoma cells.TRF1 controls telomere length and mitotic fidelity in epithelial homeostasis.Control of telomere length by a trimming mechanism that involves generation of t-circlesSwitch telomerase to ALT mechanism by inducing telomeric DNA damages and dysfunction of ATRX and DAXX.Analysis of alternative lengthening of telomere markers in BRCA1 defective cells.Alternative lengthening of human telomeres is a conservative DNA replication process with features of break-induced replication.Genistein suppresses the proliferation of telomerase-negative cells.Targeting telomerase in hematologic malignancy.Assaying and investigating Alternative Lengthening of Telomeres activity in human cells and cancers.Telomere dynamics: the influence of folate and DNA methylation.
P2860
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P2860
Telomeric recombination in mismatch repair deficient human colon cancer cells after telomerase inhibition.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Telomeric recombination in mis ...... s after telomerase inhibition.
@en
type
label
Telomeric recombination in mis ...... s after telomerase inhibition.
@en
prefLabel
Telomeric recombination in mis ...... s after telomerase inhibition.
@en
P2093
P1433
P1476
Telomeric recombination in mis ...... s after telomerase inhibition.
@en
P2093
Jerry W Shay
Oliver E Bechter
William Walker
P304
P356
10.1158/0008-5472.CAN-04-0323
P407
P577
2004-05-01T00:00:00Z