Frequent recombination in telomeric DNA may extend the proliferative life of telomerase-negative cells
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Short telomeres initiate telomere recombination in primary and tumor cellsRap1 prevents telomere fusions by nonhomologous end joining.The Role of ATRX in the Alternative Lengthening of Telomeres (ALT) PhenotypeTelomerase activity and telomere length in male germ cellsZscan4 regulates telomere elongation and genomic stability in ES cellsHistone H3.3 maintains genome integrity during mammalian developmentAssociation of BLM and BRCA1 during Telomere Maintenance in ALT CellsRif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencingRECQL4, the protein mutated in Rothmund-Thomson syndrome, functions in telomere maintenanceNr0b1 is a negative regulator of Zscan4c in mouse embryonic stem cellsUnwinding protein complexes in ALTernative telomere maintenance.Characterization of oxidative guanine damage and repair in mammalian telomeres.FANCC suppresses short telomere-initiated telomere sister chromatid exchangeHuman RECQL1 participates in telomere maintenanceATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase.An increase in telomere sister chromatid exchange in murine embryonic stem cells possessing critically shortened telomeres.Hyper telomere recombination accelerates replicative senescence and may promote premature aging.Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway.A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases.Regulatory roles of tankyrase 1 at telomeres and in DNA repair: suppression of T-SCE and stabilization of DNA-PKcs.Telomere sister chromatid exchange and the process of aging.Telomere maintenance mechanisms in cancer: clinical implicationsSIRT1 contributes to telomere maintenance and augments global homologous recombination.Long telomeres produced by telomerase-resistant recombination are established from a single source and are subject to extreme sequence scramblingTelomeres, chromosome instability and cancerRecombination can cause telomere elongations as well as truncations deep within telomeres in wild-type Kluyveromyces lactis cellsTelomere reprogramming and maintenance in porcine iPS cells.Two roles for Rad50 in telomere maintenance.Recombination can either help maintain very short telomeres or generate longer telomeres in yeast cells with weak telomerase activity.Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis.Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells.53BP1 deficiency combined with telomere dysfunction activates ATR-dependent DNA damage response.Cohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres.Deficient mismatch repair improves organismal fitness and survival of mice with dysfunctional telomeresSuv4-20h deficiency results in telomere elongation and derepression of telomere recombinationTelomere maintenance through recruitment of internal genomic regionsMaintenance of very long telomeres by recombination in the Kluyveromyces lactis stn1-M1 mutant involves extreme telomeric turnover, telomeric circles, and concerted telomeric amplification.Telomeres and Telomerase in the Radiation Response: Implications for Instability, Reprograming, and Carcinogenesis.Arsenic exposure through drinking water is associated with longer telomeres in peripheral bloodAging and immortality in a cell proliferation model
P2860
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P2860
Frequent recombination in telomeric DNA may extend the proliferative life of telomerase-negative cells
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Frequent recombination in telo ...... e of telomerase-negative cells
@en
type
label
Frequent recombination in telo ...... e of telomerase-negative cells
@en
prefLabel
Frequent recombination in telo ...... e of telomerase-negative cells
@en
P2093
P2860
P356
P1476
Frequent recombination in telo ...... e of telomerase-negative cells
@en
P2093
Edwin H Goodwin
Mark A Brenneman
Susan M Bailey
P2860
P304
P356
10.1093/NAR/GKH691
P407
P577
2004-07-16T00:00:00Z