Boca-dependent maturation of beta-propeller/EGF modules in low-density lipoprotein receptor proteins.
about
Modulation of LRP6-mediated Wnt signaling by molecular chaperone MesdHuman rhomboid family-1 gene RHBDF1 participates in GPCR-mediated transactivation of EGFR growth signals in head and neck squamous cancer cellsThe structure of MESD45-184 brings light into the mechanism of LDLR family foldingTwo Structural and Functional Domains of MESD Required for Proper Folding and Trafficking of LRP5/6Mesd is a universal inhibitor of Wnt coreceptors LRP5 and LRP6 and blocks Wnt/beta-catenin signaling in cancer cells.Proteomic plasma membrane profiling reveals an essential role for gp96 in the cell surface expression of LDLR family members, including the LDL receptor and LRP6.The C-terminal region Mesd peptide mimics full-length Mesd and acts as an inhibitor of Wnt/β-catenin signaling in cancer cells.MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.Structural characterization of the Boca/Mesd maturation factors for LDL-receptor-type β propeller domains.Drosophila KDEL receptor function in the embryonic salivary gland and epidermis.Mesd is a general inhibitor of different Wnt ligands in Wnt/LRP signaling and inhibits PC-3 tumor growth in vivo.Discovery of novel glucose-regulated proteins in isolated human pancreatic islets using LC-MS/MS-based proteomics.Frizzled and LRP5/6 receptors for Wnt/β-catenin signalingLRP5/6 in Wnt signaling and tumorigenesis.Regulation of developmental intercellular signalling by intracellular trafficking.Global Membrane Protein Interactome Analysis using In vivo Crosslinking and Mass Spectrometry-based Protein Correlation Profiling.Cooperative folding and ligand-binding properties of LRP6 beta-propeller domains.LRP-1 and LRP-2 receptors function in the membrane neuron. Trafficking mechanisms and proteolytic processing in Alzheimer's disease.Parkinson's disease-associated receptor GPR37 is an ER chaperone for LRP6.Functional characterization and classification of frequent low-density lipoprotein receptor variants.
P2860
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P2860
Boca-dependent maturation of beta-propeller/EGF modules in low-density lipoprotein receptor proteins.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Boca-dependent maturation of b ...... lipoprotein receptor proteins.
@en
type
label
Boca-dependent maturation of b ...... lipoprotein receptor proteins.
@en
prefLabel
Boca-dependent maturation of b ...... lipoprotein receptor proteins.
@en
P2860
P356
P1433
P1476
Boca-dependent maturation of b ...... lipoprotein receptor proteins
@en
P2093
Richard S Mann
Timothy A Springer
P2860
P304
P356
10.1038/SJ.EMBOJ.7600132
P407
P50
P577
2004-03-11T00:00:00Z