Anthrax lethal toxin rapidly activates caspase-1/ICE and induces extracellular release of interleukin (IL)-1beta and IL-18.
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The effects of anthrax lethal toxin on host barrier functionNalp1b controls mouse macrophage susceptibility to anthrax lethal toxinAnthrax lethal toxin induced lysosomal membrane permeabilization and cytosolic cathepsin release is Nlrp1b/Nalp1b-dependent.Bacillus anthracis capsule activates caspase-1 and induces interleukin-1beta release from differentiated THP-1 and human monocyte-derived dendritic cells.In vivo efficacy of a phosphodiester TLR-9 aptamer and its beneficial effect in a pulmonary anthrax infection modelCutting edge: resistance to Bacillus anthracis infection mediated by a lethal toxin sensitive allele of Nalp1b/Nlrp1b.Proteasome inhibitors prevent caspase-1-mediated disease in rodents challenged with anthrax lethal toxin.Rapid vascular responses to anthrax lethal toxin in mice containing a segment of chromosome 11 from the CAST/Ei strain on a C57BL/6 genetic background.Caspase-1 autoproteolysis is differentially required for NLRP1b and NLRP3 inflammasome function.The poly-γ-D-glutamic acid capsule of Bacillus anthracis enhances lethal toxin activity.Anthrolysin O and other gram-positive cytolysins are toll-like receptor 4 agonistsAnthrax lethal factor activates K(+) channels to induce IL-1β secretion in macrophages.Killing of macrophages by anthrax lethal toxin: involvement of the N-end rule pathway.Anthrax lethal toxin-induced inflammasome formation and caspase-1 activation are late events dependent on ion fluxes and the proteasomeMycobacterium tuberculosis prevents inflammasome activationHeat shock inhibits caspase-1 activity while also preventing its inflammasome-mediated activation by anthrax lethal toxin.P2 purinergic receptor modulation of cytokine production.Investigation of new dominant-negative inhibitors of anthrax protective antigen mutants for use in therapy and vaccination.Cellular and systemic effects of anthrax lethal toxin and edema toxin.Adaptation of the endogenous Salmonella enterica serovar Typhi clyA-encoded hemolysin for antigen export enhances the immunogenicity of anthrax protective antigen domain 4 expressed by the attenuated live-vector vaccine strain CVD 908-htrA.Inflammasome inhibition as a pathogenic stealth mechanism.Regulating caspase-1 during infection: roles of NLRs, AIM2, and ASC.Cleavage of the JunB transcription factor by caspases generates a carboxyl-terminal fragment that inhibits activator protein-1 transcriptional activity.Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis.Mitochondrial proteins Bnip3 and Bnip3L are involved in anthrax lethal toxin-induced macrophage cell death.Therapeutic effects of caspase-1 inhibitors on acute lung injury in experimental severe acute pancreatitisMurine macrophage transcriptional responses to Bacillus anthracis infection and intoxication.Bacillus anthracis spores and lethal toxin induce IL-1beta via functionally distinct signaling pathwaysCritical role of the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase-3 signaling pathway in recovery from anthrax lethal toxin-induced cell cycle arrest and MEK cleavage in macrophages.Linking lipid metabolism to the innate immune response in macrophages through sterol regulatory element binding protein-1a.The Canonical Inflammasome: A Macromolecular Complex Driving Inflammation.
P2860
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P2860
Anthrax lethal toxin rapidly activates caspase-1/ICE and induces extracellular release of interleukin (IL)-1beta and IL-18.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Anthrax lethal toxin rapidly a ...... erleukin (IL)-1beta and IL-18.
@en
type
label
Anthrax lethal toxin rapidly a ...... erleukin (IL)-1beta and IL-18.
@en
prefLabel
Anthrax lethal toxin rapidly a ...... erleukin (IL)-1beta and IL-18.
@en
P2093
P2860
P356
P1476
Anthrax lethal toxin rapidly a ...... erleukin (IL)-1beta and IL-18.
@en
P2093
Carla S R Lankford
David M Frucht
Ruth Cordoba-Rodriguez
P2860
P304
20563-20566
P356
10.1074/JBC.C300539200
P407
P577
2004-03-09T00:00:00Z