MSH2-dependent germinal CTG repeat expansions are produced continuously in spermatogonia from DM1 transgenic mice. - Wikidata - awgldk - TriplyDB

MSH2-dependent germinal CTG repeat expansions are produced continuously in spermatogonia from DM1 transgenic mice.

MSH2-dependent germinal CTG repeat expansions are produced continuously in spermatogonia from DM1 transgenic mice.

http://www.wikidata.org/entity/Q40581844

about

Comparative genomics and molecular dynamics of DNA repeats in eukaryotes Advances in mechanisms of genetic instability related to hereditary neurological diseases.DNA triplet repeat expansion and mismatch repair Molecular genetics and genetic testing in myotonic dystrophy type 1.Ups and Downs: Mechanisms of Repeat Instability in the Fragile X-Related Disorders Onset and progression of behavioral and molecular phenotypes in a novel congenic R6/2 line exhibiting intergenerational CAG repeat stability.Isolated short CTG/CAG DNA slip-outs are repaired efficiently by hMutSbeta, but clustered slip-outs are poorly repaired.CTCF cis-regulates trinucleotide repeat instability in an epigenetic manner: a novel basis for mutational hot spot determination.MSH2 ATPase domain mutation affects CTG*CAG repeat instability in transgenic mice.Diverse effects of individual mismatch repair components on transcription-induced CAG repeat instability in human cells.Human telomeres that contain (CTAGGG)n repeats show replication dependent instability in somatic cells and the male germline Convergent transcription through a long CAG tract destabilizes repeats and induces apoptosis Topoisomerase 1 and single-strand break repair modulate transcription-induced CAG repeat contraction in human cells.Xpa deficiency reduces CAG trinucleotide repeat instability in neuronal tissues in a mouse model of SCA1.Nucleotide excision repair, mismatch repair, and R-loops modulate convergent transcription-induced cell death and repeat instability Non-B DNA structure-induced genetic instability and evolution.Transcription elongation and tissue-specific somatic CAG instability.MSH3 polymorphisms and protein levels affect CAG repeat instability in Huntington's disease mice Microsatellite repeat instability and neurological disease.Purification, crystallization and preliminary X-ray diffraction analysis of the human mismatch repair protein MutSβ Cockayne syndrome B protein antagonizes OGG1 in modulating CAG repeat length in vivo.Mechanisms of trinucleotide repeat instability during human development Regulation of recombination at yeast nuclear pores controls repair and triplet repeat stability.Repeat instability during DNA repair: Insights from model systems Instability of (CTG)n•(CAG)n trinucleotide repeats and DNA synthesis The Repeat Expansion Diseases: The dark side of DNA repair.Altered replication in human cells promotes DMPK (CTG)(n) · (CAG)(n) repeat instability The nucleotide sequence, DNA damage location, and protein stoichiometry influence the base excision repair outcome at CAG/CTG repeats Repeat instability: mechanisms of dynamic mutations.ATR protects the genome against CGG.CCG-repeat expansion in Fragile X premutation mice.Transcription destabilizes triplet repeats Instability and chromatin structure of expanded trinucleotide repeats Dnmt1 deficiency promotes CAG repeat expansion in the mouse germline Features of trinucleotide repeat instability in vivo.Absence of MutSβ leads to the formation of slipped-DNA for CTG/CAG contractions at primate replication forks.CTG/CAG repeat instability is modulated by the levels of human DNA ligase I and its interaction with proliferating cell nuclear antigen: a distinction between replication and slipped-DNA repair Abnormal base excision repair at trinucleotide repeats associated with diseases: a tissue-selective mechanism.Expression levels of DNA replication and repair genes predict regional somatic repeat instability in the brain but are not altered by polyglutamine disease protein expression or age.The mismatch repair protein MSH2 is rate limiting for repeat expansion in a fragile X premutation mouse model.Ethidium Bromide Modifies The Agarose Electrophoretic Mobility of CAG•CTG Alternative DNA Structures Generated by PCR.

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MSH2-dependent germinal CTG repeat expansions are produced continuously in spermatogonia from DM1 transgenic mice.

http://www.wikidata.org/entity/Q40581844

description

2004 nî lūn-bûn

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2004年论文

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2004年论文

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MSH2-dependent germinal CTG re ...... onia from DM1 transgenic mice.

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MSH2-dependent germinal CTG re ...... onia from DM1 transgenic mice.

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MSH2-dependent germinal CTG re ...... onia from DM1 transgenic mice.

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MCB.24.2.629-637.2004

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Molecular and Cellular Biology

P1476

MSH2-dependent germinal CTG re ...... gonia from DM1 transgenic mice

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P2093

Claudine Junien

http://www.w3.org/2001/XMLSchema#string

Corinne Garcia-Cordier

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Cédric Savouret

http://www.w3.org/2001/XMLSchema#string

Hein te Riele

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Jérôme Megret

http://www.w3.org/2001/XMLSchema#string

P2860

The Saccharomyces cerevisiae Msh2 mismatch repair protein localizes to recombination intermediates in vivo.

hMSH5: a human MutS homologue that forms a novel heterodimer with hMSH4 and is expressed during spermatogenesis

Inhibition of FEN-1 processing by DNA secondary structure at trinucleotide repeats

Analysis of strand slippage in DNA polymerase expansions of CAG/CTG triplet repeats associated with neurodegenerative disease

Myotonic dystrophy mutation: an unstable CTG repeat in the 3' untranslated region of the gene

Single sperm analysis of the CAG repeats in the gene for dentatorubral-pallidoluysian atrophy (DRPLA): the instability of the CAG repeats in the DRPLA gene is prominent among the CAG repeat diseases

Msh2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice

Transgenic mice carrying large human genomic sequences with expanded CTG repeat mimic closely the DM CTG repeat intergenerational and somatic instability.

Huntington disease expansion mutations in humans can occur before meiosis is completed.

Cloning of the essential myotonic dystrophy region and mapping of the putative defect.

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10.1128/MCB.24.2.629-637.2004

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2

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24

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Genevieve Gourdon

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2004-01-01T00:00:00Z

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14701736

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343816

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