Huntington disease expansion mutations in humans can occur before meiosis is completed. - Wikidata - awgldk - TriplyDB

Huntington disease expansion mutations in humans can occur before meiosis is completed.

Huntington disease expansion mutations in humans can occur before meiosis is completed.

http://www.wikidata.org/entity/Q30962381

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Comparative genomics and molecular dynamics of DNA repeats in eukaryotes Inverted repeat-stimulated sister-chromatid exchange events are RAD1-independent but reduced in a msh2 mutant.DNA triplet repeat expansion and mismatch repair Molecular genetics and genetic testing in myotonic dystrophy type 1.New functions of Ctf18-RFC in preserving genome stability outside its role in sister chromatid cohesion.Interactions among DNA ligase I, the flap endonuclease and proliferating cell nuclear antigen in the expansion and contraction of CAG repeat tracts in yeast Polyalanine expansion of PHOX2B in congenital central hypoventilation syndrome: rs17884724:A>C is associated with 7-alanine expansion CTCF cis-regulates trinucleotide repeat instability in an epigenetic manner: a novel basis for mutational hot spot determination.Presentation and care of a family with Huntington disease in a resource-limited community.Double-strand break repair pathways protect against CAG/CTG repeat expansions, contractions and repeat-mediated chromosomal fragility in Saccharomyces cerevisiae Intergenerational instability of the expanded CTG repeat in the DMPK gene: studies in human gametes and preimplantation embryos.Microsatellite repeat instability and neurological disease.CAG*CTG repeat instability in cultured human astrocytes Modifiers of (CAG)(n) instability in Machado-Joseph disease (MJD/SCA3) transmissions: an association study with DNA replication, repair and recombination genes.Epigenetic mechanisms and genome stability.Mechanisms of trinucleotide repeat instability during human development Hijacking of the mismatch repair system to cause CAG expansion and cell death in neurodegenerative disease.Regulation of recombination at yeast nuclear pores controls repair and triplet repeat stability.Repeat instability during DNA repair: Insights from model systems Haploinsufficiency of yeast FEN1 causes instability of expanded CAG/CTG tracts in a length-dependent manner.Effects of Anthocyanins on CAG Repeat Instability and Behaviour in Huntington's Disease R6/1 Mice.Repeat instability: mechanisms of dynamic mutations.ATR protects the genome against CGG.CCG-repeat expansion in Fragile X premutation mice.Instability and chromatin structure of expanded trinucleotide repeats Flap endonuclease 1.Features of trinucleotide repeat instability in vivo.Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset HTRF analysis of soluble huntingtin in PHAROS PBMCs.Factors associated with HD CAG repeat instability in Huntington disease.Genetic Contributors to Intergenerational CAG Repeat Instability in Huntington's Disease Knock-In Mice.A perspective on the evolution of germ-cell development and germinal mosaics of deleterious mutations.Genetic aspects of Huntington's disease in Latin America. A systematic review.Role of recombination and replication fork restart in repeat instability.Spinocerebellar ataxia type 3/Machado-Joseph disease: segregation patterns and factors influencing instability of expanded CAG transmissions.Both CAG repeats and inverted DNA repeats stimulate spontaneous unequal sister-chromatid exchange in Saccharomyces cerevisiae.MSH2-dependent germinal CTG repeat expansions are produced continuously in spermatogonia from DM1 transgenic mice.Germline Stem Cell Competition, Mutation Hot Spots, Genetic Disorders, and Older Fathers.Genome-wide demethylation destabilizes CTG.CAG trinucleotide repeats in mammalian cells.CAG size-specific risk estimates for intermediate allele repeat instability in Huntington disease.Ancient origin of the CAG expansion causing Huntington disease in a Spanish population.

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P2860

Huntington disease expansion mutations in humans can occur before meiosis is completed.

http://www.wikidata.org/entity/Q30962381

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2003 nî lūn-bûn

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2003年の論文

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2003年論文

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2003年论文

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Huntington disease expansion mutations in humans can occur before meiosis is completed.

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Huntington disease expansion mutations in humans can occur before meiosis is completed.

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Huntington disease expansion mutations in humans can occur before meiosis is completed.

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Huntington disease expansion mutations in humans can occur before meiosis is completed.

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Huntington disease expansion mutations in humans can occur before meiosis is completed.

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Huntington disease expansion mutations in humans can occur before meiosis is completed.

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Proceedings of the National Academy of Sciences of the United States of America

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Huntington disease expansion mutations in humans can occur before meiosis is completed.

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P2093

Louis Dubeau

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Margot de Young

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Nancy S Wexler

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Norman Arnheim

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Song-Ro Yoon

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P2860

Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae

Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family

Msh2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice

Genomic instability in mice lacking histone H2AX

Dramatic mutation instability in HD mouse striatum: does polyglutamine load contribute to cell-specific vulnerability in Huntington's disease?

The mouse Spo11 gene is required for meiotic chromosome synapsis

Recombinational DNA double-strand breaks in mice precede synapsis

Laser capture microdissection: molecular analysis of tissue.

Gametic but not somatic instability of CAG repeat length in Huntington's disease.

Increased instability of human CTG repeat tracts on yeast artificial chromosomes during gametogenesis.

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Huntington disease

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166399

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