Oligonucleotides blocking glucosylceramide synthase expression selectively reverse drug resistance in cancer cells. - Wikidata - awgldk - TriplyDB

Oligonucleotides blocking glucosylceramide synthase expression selectively reverse drug resistance in cancer cells.

Oligonucleotides blocking glucosylceramide synthase expression selectively reverse drug resistance in cancer cells.

http://www.wikidata.org/entity/Q40589199

about

A new mixed-backbone oligonucleotide against glucosylceramide synthase sensitizes multidrug-resistant tumors to apoptosis Role of P-glycoprotein inhibitors in ceramide-based therapeutics for treatment of cancer.The roles of glycosphingolipids in the proliferation and neural differentiation of mouse embryonic stem cells.The impact of sphingosine kinase-1 in head and neck cancer.Ceramide glycosylation catalyzed by glucosylceramide synthase and cancer drug resistance.Direct quantitative determination of ceramide glycosylation in vivo: a new approach to evaluate cellular enzyme activity of glucosylceramide synthase.The BCL-2 protein BAK is required for long-chain ceramide generation during apoptosis.Sphingosine kinase mediates resistance to the synthetic retinoid N-(4-hydroxyphenyl)retinamide in human ovarian cancer cells.Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and beta-catenin signaling.Glucosylceramide synthesis inhibition affects cell cycle progression, membrane trafficking, and stage differentiation in Giardia lamblia.Mixed backbone antisense glucosylceramide synthase oligonucleotide (MBO-asGCS) loaded solid lipid nanoparticles: in vitro characterization and reversal of multidrug resistance in NCI/ADR-RES cells Interdiction of sphingolipid metabolism to improve standard cancer therapies.New Insights on Glucosylceramide Synthase in Cancer Drug Resistance and Myelosuppression.Inhibition of ceramide metabolism sensitizes human leukemia cells to inhibition of BCL2-like proteins Doxorubicin and MBO-asGCS oligonucleotide loaded lipid nanoparticles overcome multidrug resistance in adriamycin resistant ovarian cancer cells (NCI/ADR-RES).An increase in glucosylceramide synthase induces Bcl-xL-mediated cell survival in vinorelbine-resistant lung adenocarcinoma cells.Ceramide glycosylation by glucosylceramide synthase selectively maintains the properties of breast cancer stem cells.Sphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosis Targeting sphingolipid metabolism in head and neck cancer: rational therapeutic potentials.Lipid nanoparticles for chemotherapeutic applications: strategies to improve anticancer efficacy.Therapeutic potential of targeting ceramide/glucosylceramide pathway in cancer.The role of sphingolipids in drug metabolism and transport.Potentiation of cannabinoid-induced cytotoxicity in mantle cell lymphoma through modulation of ceramide metabolism.C6-ceramide and targeted inhibition of acid ceramidase induce synergistic decreases in breast cancer cell growth.

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P2860

Oligonucleotides blocking glucosylceramide synthase expression selectively reverse drug resistance in cancer cells.

http://www.wikidata.org/entity/Q40589199

description

2004 nî lūn-bûn

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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2004年论文

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2004年论文

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name

Oligonucleotides blocking gluc ...... ug resistance in cancer cells.

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type

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Oligonucleotides blocking gluc ...... ug resistance in cancer cells.

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Oligonucleotides blocking gluc ...... ug resistance in cancer cells.

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JLR.M300486-JLR200

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Journal of Lipid Research

P1476

Oligonucleotides blocking gluc ...... ug resistance in cancer cells.

@en

P2093

Ahn Le

http://www.w3.org/2001/XMLSchema#string

Arie Bitterman

http://www.w3.org/2001/XMLSchema#string

Armando E Giuliano

http://www.w3.org/2001/XMLSchema#string

Jing Yuan Yu

http://www.w3.org/2001/XMLSchema#string

Myles C Cabot

http://www.w3.org/2001/XMLSchema#string

Tie Yan Han

http://www.w3.org/2001/XMLSchema#string

P2860

Expression cloning of a cDNA for human ceramide glucosyltransferase that catalyzes the first glycosylation step of glycosphingolipid synthesis

Functional rafts in cell membranes

Accumulation of glucosylceramides in multidrug-resistant cancer cells

Agents that reverse multidrug resistance, tamoxifen, verapamil, and cyclosporin A, block glycosphingolipid metabolism by inhibiting ceramide glycosylation in human cancer cells

A vital role for glycosphingolipid synthesis during development and differentiation

Differential expression of sphingolipids in MRP1 overexpressing HT29 cells.

Targeting ceramide metabolism--a strategy for overcoming drug resistance.

Antisense therapeutics: is it as simple as complementary base recognition?

Regulation of glycolipid synthesis in HL-60 cells by antisense oligodeoxynucleotides to glycosyltransferase sequences: effect on cellular differentiation.

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

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933-940

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10.1194/JLR.M300486-JLR200

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