Oligonucleotides blocking glucosylceramide synthase expression selectively reverse drug resistance in cancer cells.
about
A new mixed-backbone oligonucleotide against glucosylceramide synthase sensitizes multidrug-resistant tumors to apoptosisRole of P-glycoprotein inhibitors in ceramide-based therapeutics for treatment of cancer.The roles of glycosphingolipids in the proliferation and neural differentiation of mouse embryonic stem cells.The impact of sphingosine kinase-1 in head and neck cancer.Ceramide glycosylation catalyzed by glucosylceramide synthase and cancer drug resistance.Direct quantitative determination of ceramide glycosylation in vivo: a new approach to evaluate cellular enzyme activity of glucosylceramide synthase.The BCL-2 protein BAK is required for long-chain ceramide generation during apoptosis.Sphingosine kinase mediates resistance to the synthetic retinoid N-(4-hydroxyphenyl)retinamide in human ovarian cancer cells.Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and beta-catenin signaling.Glucosylceramide synthesis inhibition affects cell cycle progression, membrane trafficking, and stage differentiation in Giardia lamblia.Mixed backbone antisense glucosylceramide synthase oligonucleotide (MBO-asGCS) loaded solid lipid nanoparticles: in vitro characterization and reversal of multidrug resistance in NCI/ADR-RES cellsInterdiction of sphingolipid metabolism to improve standard cancer therapies.New Insights on Glucosylceramide Synthase in Cancer Drug Resistance and Myelosuppression.Inhibition of ceramide metabolism sensitizes human leukemia cells to inhibition of BCL2-like proteinsDoxorubicin and MBO-asGCS oligonucleotide loaded lipid nanoparticles overcome multidrug resistance in adriamycin resistant ovarian cancer cells (NCI/ADR-RES).An increase in glucosylceramide synthase induces Bcl-xL-mediated cell survival in vinorelbine-resistant lung adenocarcinoma cells.Ceramide glycosylation by glucosylceramide synthase selectively maintains the properties of breast cancer stem cells.Sphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosisTargeting sphingolipid metabolism in head and neck cancer: rational therapeutic potentials.Lipid nanoparticles for chemotherapeutic applications: strategies to improve anticancer efficacy.Therapeutic potential of targeting ceramide/glucosylceramide pathway in cancer.The role of sphingolipids in drug metabolism and transport.Potentiation of cannabinoid-induced cytotoxicity in mantle cell lymphoma through modulation of ceramide metabolism.C6-ceramide and targeted inhibition of acid ceramidase induce synergistic decreases in breast cancer cell growth.
P2860
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P2860
Oligonucleotides blocking glucosylceramide synthase expression selectively reverse drug resistance in cancer cells.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Oligonucleotides blocking gluc ...... ug resistance in cancer cells.
@en
type
label
Oligonucleotides blocking gluc ...... ug resistance in cancer cells.
@en
prefLabel
Oligonucleotides blocking gluc ...... ug resistance in cancer cells.
@en
P2093
P2860
P1476
Oligonucleotides blocking gluc ...... ug resistance in cancer cells.
@en
P2093
Arie Bitterman
Armando E Giuliano
Jing Yuan Yu
Myles C Cabot
Tie Yan Han
P2860
P304
P356
10.1194/JLR.M300486-JLR200
P50
P577
2004-02-16T00:00:00Z