Induction of drug metabolism enzymes and MDR1 using a novel human hepatocyte cell line.
about
P1343
Relating hepatocellular carcinoma tumor samples and cell lines using gene expression data in translational researchNovel immortalized human fetal liver cell line, cBAL111, has the potential to differentiate into functional hepatocytes.A mechanism-based pharmacokinetic/pharmacodynamic model for CYP3A1/2 induction by dexamethasone in ratsDiscovery of Phenylaminopyridine Derivatives as Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors.Effects of Garlic on Cytochromes P450 2C9- and 3A4-Mediated Drug Metabolism in Human Hepatocytes.Evaluation of metabolism-mediated herb-drug interactions.Effects of rifampin and multidrug resistance gene polymorphism on concentrations of moxifloxacinScreening Ingredients from Herbs against Pregnane X Receptor in the Study of Inductive Herb-Drug Interactions: Combining Pharmacophore and Docking-Based Rank Aggregation.Organotypic liver culture models: meeting current challenges in toxicity testing.Effect of anti-tuberculosis therapy on polymorphic drug metabolizing enzyme CYP2C9 using phenytoin as a probe drug.The pregnane X receptor in tuberculosis therapeutics.Luminogenic cytochrome P450 assays.Cell-based models to study hepatic drug metabolism and enzyme induction in humans.Maximising use of in vitro ADMET tools to predict in vivo bioavailability and safety.Shear stress activation of nuclear receptor PXR in endothelial detoxification.Current industrial practices in assessing CYP450 enzyme induction: preclinical and clinicalHuman skin-derived stem cells as a novel cell source for in vitro hepatotoxicity screening of pharmaceuticals.Orphan nuclear receptors as targets for drug development.Hepatic drug-metabolizing enzyme induction and implications for preclinical and clinical risk assessment.Evaluation of models for predicting drug-drug interactions due to induction.Nuclear receptor PXR, transcriptional circuits and metabolic relevance.In vitro drug metabolism testing using blood-monocyte derivatives.Strategies for immortalization of primary hepatocytesEvaluation of a novel PXR-knockout in HepaRG™ cells.Immortalized Human Hepatic Cell Lines for In Vitro Testing and Research Purposes.HepG2 cells as an in vitro model for evaluation of cytochrome P450 induction by xenobiotics.Specific delivery of microRNA93 into HBV-replicating hepatocytes downregulates protein expression of liver cancer susceptible gene MICA.Transdifferentiation of human fibroblasts into hepatocyte-like cells by defined transcriptional factors.Efficient assessment of the utility of immortalized Fa2N-4 cells for cytochrome P450 (CYP) induction studies using multiplex quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) and substrate cassette methodologies.Influence of rifampicin on the expression and function of human intestinal cytochrome P450 enzymes.P-glycoprotein-mediated transport of moxifloxacin in a Calu-3 lung epithelial cell model.Molecular cloning and tissue distribution of a novel marmoset ABC transporter.Liver 'organ on a chip'.Effect of antituberculosis treatment on CYP2C19 enzyme activity in genetically polymorphic South Indian Tamilian population.Models and On-Chip Systems: Biomaterial Interaction Studies With Tissues Generated Using Lung Epithelial and Liver Metabolic Cell Lines
P2860
Q30965534-4D2DE36E-551C-4BBC-A102-6454028FAADFQ33511673-3D4D4624-753F-463E-8819-513FB6C3EFFDQ33567046-06B20217-584C-41CB-ABE6-54A1549AABEBQ33630579-51E66480-2879-482D-9C8B-B8B06CF47151Q34182052-CCA6044E-BD20-491E-B236-0A3C58936E89Q34238039-8499B79A-796B-407A-A50B-AEF47DEA5EE9Q35912661-82C462F8-02C3-4CE5-8C11-2A5EF6BF47D2Q35960314-5D3616E6-C3D3-44AC-924A-B668A0FABE69Q36178225-13313430-45E8-4305-943F-E78B27AAE96FQ36313485-84E28C58-32C4-4D80-9761-D51DB767F112Q36451492-1F0E27C6-0E0C-491C-A22C-A8AC9263C9D6Q36543124-555EFDDB-6FF3-4AA7-B012-801711CCC50FQ36572634-D5E96339-B4BA-41FF-A3A6-BF8F25A55A03Q36960535-CA092813-790F-4D09-A5C1-B45195DA5300Q37088649-C87E8A09-769D-4C5C-BCC0-0E28B47DCBA3Q37237446-6A7FF0D2-A4A2-4E48-8C01-86749F2F9C61Q37409080-A529A4F7-88AE-4CEC-AF2D-F693F0EFD0E6Q37725708-A1AA3153-D240-459D-8651-EECF53B0E69AQ37771144-02FE8818-CDF3-4C50-A328-AEF1914F30F9Q37800932-E8271039-AD19-4265-B14B-D0E09DF8FD50Q37835926-37D4B139-EFC3-4CC9-9FC4-907D01D62259Q38132218-CE8769C9-223C-47D5-8106-DD556CFAED74Q38218749-ABBAACAF-A550-469A-ADDB-CDD4A987E641Q38742139-4A46169A-EA7C-48D0-BB61-E6725D0EBAABQ38843888-E8C7E60E-2393-445E-8E39-5E9A71AA2EEFQ38945994-F50D3C9A-3AF0-4402-BC72-001317049945Q38975168-9841EF5C-43A8-40F6-A704-FD5180D15BEBQ39395084-DED21FFB-2A6C-46BE-8E6F-7C2CAE4E6C69Q39920320-3B0E1F21-EDB7-4B3D-A4A0-D8484EE53D47Q42129498-BB12D4A3-D683-4B44-9C38-6BBFD4A6879DQ43075165-E773F083-2319-4E61-812F-9A300BA5A09DQ46277294-6A39B7E3-70DF-4CEA-B79B-75D1B3FC90AEQ47207257-F6BEFA24-DDCB-43DE-B995-AD56A0516C47Q51653421-70D36E11-127B-41FB-A435-7B4C96653CA3Q57161670-A25504E2-21A2-4D83-9A2E-91C407A302E9
P2860
Induction of drug metabolism enzymes and MDR1 using a novel human hepatocyte cell line.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Induction of drug metabolism enzymes and MDR1 using a novel human hepatocyte cell line.
@en
type
label
Induction of drug metabolism enzymes and MDR1 using a novel human hepatocyte cell line.
@en
prefLabel
Induction of drug metabolism enzymes and MDR1 using a novel human hepatocyte cell line.
@en
P2093
P356
P1476
Induction of drug metabolism enzymes and MDR1 using a novel human hepatocyte cell line.
@en
P2093
Jasminder Sahi
Jessica B Mills
Kelly A Rose
Nalini Sadagopan
Sonia M F de Morais
P304
P356
10.1124/JPET.103.061713
P407
P4510
P577
2004-01-13T00:00:00Z