A signaling pathway governing early thymocyte maturation.
about
CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturationMetabolites from apoptotic thymocytes inhibit thymopoiesis in adenosine deaminase-deficient fetal thymic organ culturesImpaired bone marrow microenvironment and immune function in T cell protein tyrosine phosphatase-deficient miceThe tyrosine phosphatase SHP-1 influences thymocyte selection by setting TCR signaling thresholds.SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levelsLack of SHPTP1 results in src-family kinase hyperactivation and thymocyte hyperresponsiveness.Dysregulation of the protein tyrosine kinase LCK in lymphoproliferative disorders and in other neoplasias.Lck protein tyrosine kinase is a key regulator of T-cell activation and a target for signal intervention by Herpesvirus saimiri and other viral gene products.Integrin-mediated tyrosine phosphorylation of Shc in T cells is regulated by protein kinase C-dependent phosphorylations of LckReal-time PCR method for the quantitative analysis of human T-cell receptor gamma and beta gene rearrangements.Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes.The immunosuppressant 15-deoxyspergualin [correction of 1,5-deoxyspergualin] reveals commonality between preT and preB cell differentiation.The transcriptional repressor Gfi1 affects development of early, uncommitted c-Kit+ T cell progenitors and CD4/CD8 lineage decision in the thymusLck domains differentially contribute to pre-T cell receptor (TCR)- and TCR-alpha/beta-regulated developmental transitionsReplacement of pre-T cell receptor signaling functions by the CD4 coreceptorInterleukin 2-mediated uncoupling of T cell receptor alpha/beta from CD3 signaling.Network rewiring is an important mechanism of gene essentiality changeCD3-epsilon overexpressed in prothymocytes acts as an oncogene.Early T-cell development in CD3-deficient mice.Insights into T cell development and signal transduction provided by TCR-zeta chain deficient mice.Extracellular signal-regulated kinase (ERK) activation by the pre-T cell receptor in developing thymocytes in vivo.Skewed T-cell receptor Vbeta8.2 expression in transgenic CD2-myc induced thymic lymphoma: a role for antigen stimulation in tumour development?
P2860
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P2860
A signaling pathway governing early thymocyte maturation.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
A signaling pathway governing early thymocyte maturation.
@en
type
label
A signaling pathway governing early thymocyte maturation.
@en
prefLabel
A signaling pathway governing early thymocyte maturation.
@en
P1433
P1476
A signaling pathway governing early thymocyte maturation.
@en
P2093
Anderson SJ
Perlmutter RM
P304
P356
10.1016/0167-5699(95)80096-4
P577
1995-02-01T00:00:00Z