Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes.
about
The human cytomegalovirus UL11 protein interacts with the receptor tyrosine phosphatase CD45, resulting in functional paralysis of T cellsTyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of LckA Zn2+ ion links the cytoplasmic tail of CD4 and the N-terminal region of LckDifferential role of glycolipid-enriched membrane domains in glycoprotein VI- and integrin-mediated phospholipase Cgamma2 regulation in plateletsTyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signalingSignalling pathways induced by protease-activated receptors and integrins in T cellsThe role of T cell receptor signaling thresholds in guiding T cell fate decisionsCa2+ release from the endoplasmic reticulum of NY-ESO-1-specific T cells is modulated by the affinity of TCR and by the use of the CD8 coreceptor.Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase LinkerItk/Emt/Tsk activation in response to CD3 cross-linking in Jurkat T cells requires ZAP-70 and Lat and is independent of membrane recruitmentVav1 and Ly-GDI two regulators of Rho GTPases, function cooperatively as signal transducers in T cell antigen receptor-induced pathwaysTyrosine 474 of ZAP-70 is required for association with the Shc adaptor and for T-cell antigen receptor-dependent gene activationSchlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1Phosphorylation site dynamics of early T-cell receptor signalingDevelopment of T-leukaemias in CD45 tyrosine phosphatase-deficient mutant lck miceA critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophagesLck SH3 domain function is required for T-cell receptor signals regulating thymocyte development.Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signalingThe lck SH3 domain is required for activation of the mitogen-activated protein kinase pathway but not the initiation of T-cell antigen receptor signaling.Roles of the Src tyrosine kinases Lck and Fyn in regulating gammadeltaTCR signal strengthNovel tools to dissect the dynamic regulation of TCR signaling by the kinase Csk and the phosphatase CD45RhoH regulates subcellular localization of ZAP-70 and Lck in T cell receptor signaling.T cell receptor signal initiation induced by low-grade stimulation requires the cooperation of LAT in human T cells.Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line.T-cell receptor-mediated anergy of a human immunodeficiency virus (HIV) gp120-specific CD4(+) cytotoxic T-cell clone, induced by a natural HIV type 1 variant peptide.CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic developmentS-acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes.Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains.Phosphorylation of Tyr319 in ZAP-70 is required for T-cell antigen receptor-dependent phospholipase C-gamma1 and Ras activation.T cell signaling and autoimmune diabetes.HIV-1 Nef: a multifaceted modulator of T cell receptor signaling.Quantitative phosphoproteomics reveals SLP-76 dependent regulation of PAG and Src family kinases in T cellsLigand-engaged TCR is triggered by Lck not associated with CD8 coreceptorA model of an integrated immune system pathway in Homo sapiens and its interaction with superantigen producing expression regulatory pathway in Staphylococcus aureus: comparing behavior of pathogen perturbed and unperturbed pathwayLck regulates the threshold of activation in primary T cells, while both Lck and Fyn contribute to the magnitude of the extracellular signal-related kinase response.Differential requirement for Lck during primary and memory CD8+ T cell responsesTargeted Sos1 deletion reveals its critical role in early T-cell development.Vav1 Regulates T-Cell Activation through a Feedback Mechanism and Crosstalk between the T-Cell Receptor and CD28.The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signalingMolecular basis for T cell response induced by altered peptide ligand of type II collagen.
P2860
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P2860
Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
Lck regulates the tyrosine pho ...... d ZAP-70 in murine thymocytes.
@ast
Lck regulates the tyrosine pho ...... d ZAP-70 in murine thymocytes.
@en
type
label
Lck regulates the tyrosine pho ...... d ZAP-70 in murine thymocytes.
@ast
Lck regulates the tyrosine pho ...... d ZAP-70 in murine thymocytes.
@en
prefLabel
Lck regulates the tyrosine pho ...... d ZAP-70 in murine thymocytes.
@ast
Lck regulates the tyrosine pho ...... d ZAP-70 in murine thymocytes.
@en
P2093
P2860
P356
P1476
Lck regulates the tyrosine pho ...... d ZAP-70 in murine thymocytes.
@en
P2093
P2860
P304
P356
10.1084/JEM.183.3.1053
P407
P577
1996-03-01T00:00:00Z