Relative contribution of Nedd4 and Nedd4-2 to ENaC regulation in epithelia determined by RNA interference.
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Nedd4-2 and the regulation of epithelial sodium transportLipopolysaccharide hyperpolarizes guinea pig airway epithelium by increasing the activities of the epithelial Na+ channel and the Na+ - K+ pumpHECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACKCOMMD1 downregulates the epithelial sodium channel through Nedd4-2Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptorThe ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channelsCalcium activates Nedd4 E3 ubiquitin ligases by releasing the C2 domain-mediated auto-inhibitionSalt handling and hypertensionNedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functionsNedd4-2 isoforms ubiquitinate individual epithelial sodium channel subunits and reduce surface expression and function of the epithelial sodium channelNew insights into sodium transport regulation in the distal nephron: Role of G-protein coupled receptorsUbiquitylation as a Rheostat for TCR Signaling: From Targeted Approaches Toward Global ProfilingUbiquitylation and control of renal Na+ balance and blood pressureThe epsin protein family: coordinators of endocytosis and signalingVasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3Nedd4-2 induces endocytosis and degradation of proteolytically cleaved epithelial Na+ channelsSalt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin ligase Nedd4-2HECT E3s and human disease.Endocytic regulation of alkali metal transport proteins in mammals, yeast and plants.Interaction of serum- and glucocorticoid regulated kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulationEpithelial transport during septic acute kidney injury.Phosphopeptide screen uncovers novel phosphorylation sites of Nedd4-2 that potentiate its inhibition of the epithelial Na+ channel.RasGRP1 stimulation enhances ubiquitination and endocytosis of the sodium-chloride cotransporterInducible kidney-specific Sgk1 knockout mice show a salt-losing phenotype.Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertensionNedd4-2 functionally interacts with ClC-5: involvement in constitutive albumin endocytosis in proximal tubule cells.Nedd4-2 isoforms differentially associate with ENaC and regulate its activity.Liddle's syndrome mutations increase Na+ transport through dual effects on epithelial Na+ channel surface expression and proteolytic cleavage.Nedd4-mediated increase in HIV-1 Gag and Env proteins and immunity following DNA-vaccination of BALB/c miceH-Ras mediates the inhibitory effect of epidermal growth factor on the epithelial Na+ channelNeural precursor cell-expressed developmentally down-regulated protein 4-2 (Nedd4-2) regulation by 14-3-3 protein binding at canonical serum and glucocorticoid kinase 1 (SGK1) phosphorylation sites.Epigenetic silencing of ITGA2 by MiR-373 promotes cell migration in breast cancerSGK1: a rapid aldosterone-induced regulator of renal sodium reabsorption.Ubiquitylation of ion channels.Acute ENaC stimulation by cAMP in a kidney cell line is mediated by exocytic insertion from a recycling channel pool.Hypertension, kidney, and transgenics: a fresh perspective.H2O2 regulates lung epithelial sodium channel (ENaC) via ubiquitin-like protein Nedd8.Effect of aldosterone on BK channel expression in mammalian cortical collecting duct.Nedd4-2 but not Nedd4-1 is critical for protein kinase C-regulated ubiquitination, expression, and transport activity of human organic anion transporter 1An obligatory heterodimer of 14-3-3beta and 14-3-3epsilon is required for aldosterone regulation of the epithelial sodium channel.
P2860
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P2860
Relative contribution of Nedd4 and Nedd4-2 to ENaC regulation in epithelia determined by RNA interference.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Relative contribution of Nedd4 ...... etermined by RNA interference.
@en
type
label
Relative contribution of Nedd4 ...... etermined by RNA interference.
@en
prefLabel
Relative contribution of Nedd4 ...... etermined by RNA interference.
@en
P2093
P2860
P356
P1476
Relative contribution of Nedd4 ...... etermined by RNA interference.
@en
P2093
Diane R Olson
Jennifer C Steines
Peter M Snyder
P2860
P304
P356
10.1074/JBC.M312477200
P407
P577
2003-11-26T00:00:00Z