about
Protein kinase C α is a central signaling node and therapeutic target for breast cancer stem cellsmiR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis.Concurrent suppression of integrin alpha5, radixin, and RhoA phenocopies the effects of miR-31 on metastasisActivation of miR-31 function in already-established metastases elicits metastatic regressionA pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasisThe Spemann organizer gene, Goosecoid, promotes tumor metastasisLACTB is a tumour suppressor that modulates lipid metabolism and cell state.Systemic endocrine instigation of indolent tumor growth requires osteopontin.SMARCE1 is required for the invasive progression of in situ cancersLoss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failureTherapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model.Prolyl isomerase Pin1 acts downstream of miR200c to promote cancer stem-like cell traits in breast cancerSlug and Sox9 cooperatively determine the mammary stem cell state.Distinct EMT programs control normal mammary stem cells and tumour-initiating cells.Normal and neoplastic nonstem cells can spontaneously convert to a stem-like stateActivation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability.Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in miceDihydropyrimidine accumulation is required for the epithelial-mesenchymal transition.Enrichment of a population of mammary gland cells that form mammospheres and have in vivo repopulating activity.A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages.Gene expression signature of normal cell-of-origin predicts ovarian tumor outcomes.Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expressionThe outgrowth of micrometastases is enabled by the formation of filopodium-like protrusions.Neutrophils Suppress Intraluminal NK Cell-Mediated Tumor Cell Clearance and Enhance Extravasation of Disseminated Carcinoma Cells.Cancer-stimulated mesenchymal stem cells create a carcinoma stem cell niche via prostaglandin E2 signaling.Concomitant suppression of three target genes can explain the impact of a microRNA on metastasisParacrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast.Integrin-β4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells.Epithelial-to-mesenchymal transition activates PERK-eIF2α and sensitizes cells to endoplasmic reticulum stress.Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity.
P50
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P50
description
onderzoeker
@nl
name
Ferenc Reinhardt
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Ferenc Reinhardt
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Ferenc Reinhardt
@es
Ferenc Reinhardt
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type
label
Ferenc Reinhardt
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Ferenc Reinhardt
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Ferenc Reinhardt
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Ferenc Reinhardt
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prefLabel
Ferenc Reinhardt
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Ferenc Reinhardt
@en
Ferenc Reinhardt
@es
Ferenc Reinhardt
@sl