A definitive role of Shp-2 tyrosine phosphatase in mediating embryonic stem cell differentiation and hematopoiesis.
about
Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesisPluripotency Factors on Their Lineage MoveShp2-mediated molecular signaling in control of embryonic stem cell self-renewal and differentiationProtein tyrosine phosphatases in the JAK/STAT pathwayA conserved mechanism for control of human and mouse embryonic stem cell pluripotency and differentiation by shp2 tyrosine phosphatase.A genome-wide siRNA screen identifies novel phospho-enzymes affecting Wnt/β-catenin signaling in mouse embryonic stem cells.Enhanced generation of myeloid lineages in hematopoietic differentiation from embryonic stem cells by silencing transcriptional repressor Twist-2Embryonic stem cells and mammary luminal progenitors directly sense and respond to microbial products.Development of severe skeletal defects in induced SHP-2-deficient adult mice: a model of skeletal malformation in humans with SHP-2 mutationsSHP2 positively regulates TGFβ1-induced epithelial-mesenchymal transition modulated by its novel interacting protein Hook1.Modeling murine yolk sac hematopoiesis with embryonic stem cell culture systems.Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells.Kit-Shp2-Kit signaling acts to maintain a functional hematopoietic stem and progenitor cell pool.A critical role for SHP2 in STAT5 activation and growth factor-mediated proliferation, survival, and differentiation of human CD34+ cells.Zap70 functions to maintain stemness of mouse embryonic stem cells by negatively regulating Jak1/Stat3/c-Myc signaling.Conditional deletion of Shp2 in the mammary gland leads to impaired lobulo-alveolar outgrowth and attenuated Stat5 activationPTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase.Shp2 function in hematopoietic stem cell biology and leukemogenesis.Mediating ERK 1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome.Deletion of Shp2 in the brain leads to defective proliferation and differentiation in neural stem cells and early postnatal lethalityDesigner blood: creating hematopoietic lineages from embryonic stem cells.Nonreceptor tyrosine phosphatase Shp2 promotes adipogenesis through inhibition of p38 MAP kinase.Hematopoietic colony formation from human growth factor-dependent TF1 cells and human cord blood myeloid progenitor cells depends on SHP2 phosphatase functionEosinophil differentiation in the bone marrow is promoted by protein tyrosine phosphatase SHP2.Decursin and Doxorubicin Are in Synergy for the Induction of Apoptosis via STAT3 and/or mTOR Pathways in Human Multiple Myeloma Cells.Activating PTPN11 mutants promote hematopoietic progenitor cell-cycle progression and survival.Novel Function of Sprouty4 as a Regulator of Stemness and Differentiation of Embryonic Stem CellsIncreased c-Jun expression and reduced GATA2 expression promote aberrant monocytic differentiation induced by activating PTPN11 mutantsNegative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemia.Protein post-translational modifications and regulation of pluripotency in human stem cells.The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo.The Role of the Leukemia Inhibitory Factor (LIF) - Pathway in Derivation and Maintenance of Murine Pluripotent Stem Cells.Lefty1 and lefty2 control the balance between self-renewal and pluripotent differentiation of mouse embryonic stem cells.Shp2 Inhibits Proliferation of Esophageal Squamous Cell Cancer via Dephosphorylation of Stat3Key players in the gene networks guiding ESCs toward mesoderm.Regulating naïve and memory CD8 T cell homeostasis--a role for protein tyrosine phosphatases.Regulators of pluripotency and their implications in regenerative medicine.Phosphorylation states of STAT3 and ERKs in mouse embryonic stem cells.Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia.SHP2 is a downstream target of ZAP70 to regulate JAK1/STAT3 and ERK signaling pathways in mouse embryonic stem cells.
P2860
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P2860
A definitive role of Shp-2 tyrosine phosphatase in mediating embryonic stem cell differentiation and hematopoiesis.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
A definitive role of Shp-2 tyr ...... erentiation and hematopoiesis.
@en
type
label
A definitive role of Shp-2 tyr ...... erentiation and hematopoiesis.
@en
prefLabel
A definitive role of Shp-2 tyr ...... erentiation and hematopoiesis.
@en
P2093
P1433
P1476
A definitive role of Shp-2 tyr ...... erentiation and hematopoiesis.
@en
P2093
Gen-Sheng Feng
Mervin C Yoder
Rebecca J Chan
Scott A Johnson
P304
P356
10.1182/BLOOD-2003-04-1171
P407
P577
2003-06-05T00:00:00Z