Activating PTPN11 mutants promote hematopoietic progenitor cell-cycle progression and survival. - Wikidata - awgldk - TriplyDB

Activating PTPN11 mutants promote hematopoietic progenitor cell-cycle progression and survival.

Activating PTPN11 mutants promote hematopoietic progenitor cell-cycle progression and survival.

http://www.wikidata.org/entity/Q37034852

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Protein tyrosine phosphatases as potential therapeutic targets.SHP2 is a target of the immunosuppressant tautomycetin.Functions of Shp2 in cancer.Genetic disruption of the PI3K regulatory subunits, p85α, p55α, and p50α, normalizes mutant PTPN11-induced hypersensitivity to GM-CSF.A comprehensive analysis of GATA-1-regulated miRNAs reveals miR-23a to be a positive modulator of erythropoiesis.A tyrosine phosphatase SHP2 gain-of-function mutation enhances malignancy of breast carcinoma Increased c-Jun expression and reduced GATA2 expression promote aberrant monocytic differentiation induced by activating PTPN11 mutants Protein kinase networks regulating glucocorticoid-induced apoptosis of hematopoietic cancer cells: fundamental aspects and practical considerations.Bcl-2 proteins in development, health, and disease of the hematopoietic system.Cooperation of MLL/AF10(OM-LZ) with PTPN11 activating mutation induced monocytic leukemia with a shorter latency in a mouse bone marrow transplantation model.Gene mutations in the Ras pathway and the prognostic implication in Korean patients with juvenile myelomonocytic leukemia.SHP2-Mediated Signal Networks in Stem Cell Homeostasis and Dysfunction.

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Activating PTPN11 mutants promote hematopoietic progenitor cell-cycle progression and survival.

http://www.wikidata.org/entity/Q37034852

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 21 July 2008

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Activating PTPN11 mutants prom ...... ycle progression and survival.

@en

Activating PTPN11 mutants prom ...... ycle progression and survival.

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type

label

Activating PTPN11 mutants prom ...... ycle progression and survival.

@en

Activating PTPN11 mutants prom ...... ycle progression and survival.

@nl

prefLabel

Activating PTPN11 mutants prom ...... ycle progression and survival.

@en

Activating PTPN11 mutants prom ...... ycle progression and survival.

@nl

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J.EXPHEM.2008.04.016

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Experimental Hematology

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Activating PTPN11 mutants prom ...... ycle progression and survival.

@en

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Fuqin Yin

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Rebecca J Chan

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Yiping Li

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Zhenyun Yang

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P2860

Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

Interleukin (IL)-3 and granulocyte/macrophage colony-stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and phosphatidylinositol 3'-kinase

New functional activities for the p21 family of CDK inhibitors

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

Pharmacological manipulation of cell death: clinical applications in sight?

Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation

Cell death: critical control points

p21 is a universal inhibitor of cyclin kinases

Cell cycle targets of Ras/Raf signalling

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1285-1296

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scholarly article

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10.1016/J.EXPHEM.2008.04.016

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10

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36

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