about
The Ras signaling inhibitor LOX-PP interacts with Hsp70 and c-Raf to reduce Erk activation and transformed phenotype of breast cancer cellsThe lysyl oxidase propeptide interacts with the receptor-type protein tyrosine phosphatase kappa and inhibits β-catenin transcriptional activity in lung cancer cellsInhibition of CIN85-mediated invasion by a novel SH3 domain binding motif in the lysyl oxidase propeptide.UXT Is a LOX-PP Interacting Protein That Modulates Estrogen Receptor Alpha Activity in Breast Cancer Cells.Enhanced chondrogenesis and Wnt signaling in PTH-treated fractures.Downregulation of Lysyl Oxidase Protects Retinal Endothelial Cells From High Glucose-Induced ApoptosisLysyl oxidase propeptide inhibits FGF-2-induced signaling and proliferation of osteoblasts.Epithelial to mesenchymal transition in gingival overgrowth.Recombinant lysyl oxidase propeptide protein inhibits growth and promotes apoptosis of pre-existing murine breast cancer xenograftsBlimp1 activation by AP-1 in human lung cancer cells promotes a migratory phenotype and is inhibited by the lysyl oxidase propeptide.High glucose increases lysyl oxidase expression and activity in retinal endothelial cells: mechanism for compromised extracellular matrix barrier function.Molecular and clinical aspects of drug-induced gingival overgrowth.A fluorometric assay for detection of lysyl oxidase enzyme activity in biological samples.CCN2, connective tissue growth factor, stimulates collagen deposition by gingival fibroblasts via module 3 and alpha6- and beta1 integrins.Control of megakaryocyte expansion and bone marrow fibrosis by lysyl oxidase.A novel function for lysyl oxidase in pluripotent mesenchymal cell proliferation and relevance to inflammation-associated osteopeniaPrevention of phenytoin-induced gingival overgrowth by lovastatin in miceConnective tissue metabolism and gingival overgrowth.Advanced glycation end products stimulate osteoblast apoptosis via the MAP kinase and cytosolic apoptotic pathways.Diverse biological functions of extracellular collagen processing enzymesLysyl oxidase is associated with increased thrombosis and platelet reactivity.Tissue-specific mechanisms for CCN2/CTGF persistence in fibrotic gingiva: interactions between cAMP and MAPK signaling pathways, and prostaglandin E2-EP3 receptor mediated activation of the c-JUN N-terminal kinase.Activation of RAGE induces elevated O2- generation by mononuclear phagocytes in diabetesEnzymatic and non-enzymatic functions of the lysyl oxidase family in boneHypoxia-inducible factor 1-regulated lysyl oxidase is involved in Staphylococcus aureus abscess formationThe lysyl oxidase pro-peptide attenuates fibronectin-mediated activation of focal adhesion kinase and p130Cas in breast cancer cellsRequirement for active glycogen synthase kinase-3β in TGF-β1 upregulation of connective tissue growth factor (CCN2/CTGF) levels in human gingival fibroblasts.A loss-of-function polymorphism in the propeptide domain of the LOX gene and breast cancer.Role of lysyl oxidase propeptide in secretion and enzyme activity.Lysyl oxidase propeptide sensitizes pancreatic and breast cancer cells to doxorubicin-induced apoptosis.Report on the 7(th) international workshop on the CCN family of genes : October 16-19, 2013-Nice, France.Lysyl Oxidase Isoforms and Potential Therapeutic Opportunities for Fibrosis and Cancer.Determination of cell uptake pathways for tumor inhibitor lysyl oxidase propeptide.Orthotopic non-metastatic and metastatic oral cancer mouse models.Effects of tumor-suppressor lysyl oxidase propeptide on prostate cancer xenograft growth and its direct interactions with DNA repair pathways.Lysyl oxidase (lox) gene deficiency affects osteoblastic phenotype.Transforming growth factor-beta1 (TGFbeta1) stimulates connective tissue growth factor (CCN2/CTGF) expression in human gingival fibroblasts through a RhoA-independent, Rac1/Cdc42-dependent mechanism: statins with forskolin block TGFbeta1-induced CCNLysyl oxidase propeptide inhibits prostate cancer cell growth by mechanisms that target FGF-2-cell binding and signaling.An interesting perspective on a well-studied pathway: does type III TGF-Β receptor have therapeutic potential?Diabetes-induced fibrotic matrix inhibits intramembranous bone healing.
P50
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P50
description
hulumtues
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researcher
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wetenschapper
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հետազոտող
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name
Philip C Trackman
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Philip C Trackman
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Philip C Trackman
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Philip C Trackman
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Philip C Trackman
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type
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Philip C Trackman
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Philip C Trackman
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Philip C Trackman
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Philip C Trackman
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Philip C Trackman
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prefLabel
Philip C Trackman
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Philip C Trackman
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Philip C Trackman
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Philip C Trackman
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Philip C Trackman
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P106
P21
P31
P496
0000-0001-5064-614X