A function for the integrin alpha 6 beta 4 in the hemidesmosome.
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A homozygous mutation in the integrin alpha6 gene in junctional epidermolysis bullosa with pyloric atresiaBPAG1e maintains keratinocyte polarity through beta4 integrin-mediated modulation of Rac1 and cofilin activitiesMultiple functions of the integrin alpha6beta4 in epidermal homeostasis and tumorigenesisThe slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes.Anchorage mediated by integrin alpha6beta4 to laminin 5 (epiligrin) regulates tyrosine phosphorylation of a membrane-associated 80-kD proteinSynapse adhesion: a dynamic equilibrium conferring stability and flexibilityBeta4 integrin is required for hemidesmosome formation, cell adhesion and cell survivalExpression of integrin alpha6beta1 enhances tumorigenesis in glioma cellsPhosphorylation of a conserved integrin alpha 3 QPSXXE motif regulates signaling, motility, and cytoskeletal engagement.Integrin beta4 regulates migratory behavior of keratinocytes by determining laminin-332 organizationUnique expression pattern of the alpha6beta4 integrin and laminin-5 in human prostate carcinomaRole of cell surface metalloprotease MT1-MMP in epithelial cell migration over laminin-5.Structural cues from the tissue microenvironment are essential determinants of the human mammary epithelial cell phenotype.A splice variant of alpha 6 integrin is associated with malignant conversion in mouse skin tumorigenesisHerlitz junctional epidermolysis bullosa keratinocytes display heterogeneous defects of nicein/kalinin gene expressionIdentification of a new hemidesmosomal protein, HD1: a major, high molecular mass component of isolated hemidesmosomes.Different phenotypes in human prostate cancer: alpha6 or alpha3 integrin in cell-extracellular adhesion sites180-kD bullous pemphigoid antigen (BP180) is deficient in generalized atrophic benign epidermolysis bullosa.Integrin clipping: a novel adhesion switch?Expression of epithelial adhesion proteins and integrins in chronic inflammationExpression of hemidesmosomes and component proteins is lost by invasive breast cancer cells.α6β4 integrin, a master regulator of expression of integrins in human keratinocytes.Spontaneous skin erosions and reduced skin and corneal wound healing characterize CLIC4(NULL) mice.Biochemical characterization and tissue distribution of the A and B variants of the integrin alpha 6 subunitAxonal regulation of Schwann cell integrin expression suggests a role for alpha 6 beta 4 in myelination.IFAP 300 is common to desmosomes and hemidesmosomes and is a possible linker of intermediate filaments to these junctions.The integrin alpha6beta4 functions in carcinoma cell migration on laminin-1 by mediating the formation and stabilization of actin-containing motility structuresLaminin 5 in the human thymus: control of T cell proliferation via alpha6beta4 integrinsCellular interaction of integrin alpha3beta1 with laminin 5 promotes gap junctional communication.alpha3beta1 Integrin is required for normal development of the epidermal basement membrane.A recombinant tail-less integrin beta 4 subunit disrupts hemidesmosomes, but does not suppress alpha 6 beta 4-mediated cell adhesion to laminins.Surface relocation of alpha 6 beta 4 integrins and assembly of hemidesmosomes in an in vitro model of wound healing.Proteolytic processing of endogenous and recombinant beta 4 integrin subunitType VII collagen regulates expression of OATP1B3, promotes front-to-rear polarity and increases structural organisation in 3D spheroid cultures of RDEB tumour keratinocytes.Integrin alpha 6 expression in human prostate carcinoma cells is associated with a migratory and invasive phenotype in vitro and in vivoSpecificity of binding of the plectin actin-binding domain to beta4 integrin.The beta 4 subunit cytoplasmic domain mediates the interaction of alpha 6 beta 4 integrin with the cytoskeleton of hemidesmosomes.Integrin alpha 6 beta 4 forms a complex with the cytoskeletal protein HD1 and induces its redistribution in transfected COS-7 cells.Human autoantibodies against the 230-kD bullous pemphigoid antigen (BPAG1) bind only to the intracellular domain of the hemidesmosome, whereas those against the 180-kD bullous pemphigoid antigen (BPAG2) bind along the plasma membrane of the hemidesmExpression of integrins and basement membrane components by wound keratinocytes.
P2860
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P2860
A function for the integrin alpha 6 beta 4 in the hemidesmosome.
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
1991年论文
@zh
1991年论文
@zh-cn
name
A function for the integrin alpha 6 beta 4 in the hemidesmosome.
@en
type
label
A function for the integrin alpha 6 beta 4 in the hemidesmosome.
@en
prefLabel
A function for the integrin alpha 6 beta 4 in the hemidesmosome.
@en
P2093
P2860
P356
P1476
A function for the integrin alpha 6 beta 4 in the hemidesmosome.
@en
P2093
H M Cooper
M A Kurpakus
V Quaranta
P2860
P304
P356
10.1091/MBC.2.6.427
P577
1991-06-01T00:00:00Z