The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction.
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SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T cell activationSKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcriptionSubdomain X of the kinase domain of Lck binds CD45 and facilitates dephosphorylationImmunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cellsMolecular mechanism of the Syk activation switchMechanism of activation for Zap-70 catalytic activityRecruitment of tyrosine phosphatase HCP by the killer cell inhibitor receptorDemonstration of a direct interaction between p56lck and the cytoplasmic domain of CD45 in vitroAnalysis of the interaction of ZAP-70 and syk protein-tyrosine kinases with the T-cell antigen receptor by plasmon resonancePhosphotyrosine-independent binding of a 62-kDa protein to the src homology 2 (SH2) domain of p56lck and its regulation by phosphorylation of Ser-59 in the lck unique N-terminal regionDok-3, a novel adapter molecule involved in the negative regulation of immunoreceptor signalingCytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptorMolecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cellsDistinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor functionDefective T cell receptor-mediated signal transduction in memory CD4 T lymphocytes exposed to superantigen or anti-T cell receptor antibodiesT Cells and Gene Regulation: The Switching On and Turning Up of Genes after T Cell Receptor Stimulation in CD8 T CellsFyn and Lck tyrosine kinases regulate tyrosine phosphorylation of p105CasL, a member of the p130Cas docking protein family, in T-cell receptor-mediated signallingSKAP55 recruits to lipid rafts and positively mediates the MAPK pathway upon T cell receptor activationCharacterization of Lnk. An adaptor protein expressed in lymphocytesInteractions between the protein-tyrosine kinase ZAP-70, the proto-oncoprotein Vav, and tubulin in Jurkat T cellsDifferential regulation of activation-induced tyrosine phosphorylation and recruitment of SLP-76 to Vav by distinct isoforms of the CD45 protein-tyrosine phosphataseInteraction of peptides derived from the Fas ligand with the Fyn-SH3 domainThe protein-tyrosine kinase Lck associates with and is phosphorylated by Cdc2PTP-PEST, a scaffold protein tyrosine phosphatase, negatively regulates lymphocyte activation by targeting a unique set of substratesImpaired development of V gamma 3 dendritic epidermal T cells in p56lck protein tyrosine kinase-deficient and CD45 protein tyrosine phosphatase-deficient miceGold is a T cell polyclonal activator in BN and LEW rats but favors IL-4 expression only in autoimmune prone BN ratsDownstream signaling molecules bind to different phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) peptides of the high affinity IgE receptorPhosphorylation-dependent regulation of T-cell activation by PAG/Cbp, a lipid raft-associated transmembrane adaptorThe MAR-binding protein SATB1 orchestrates temporal and spatial expression of multiple genes during T-cell developmentLigation of the T-cell Antigen Receptor (TCR) Induces Association of hSos1, ZAP-70, Phospolipase C- 1, and Other Phosphoproteins with Grb2 and the -Chain of the TCRAssociation of p59(fyn) with the T lymphocyte costimulatory receptor CD2. Binding of the Fyn Src homology (SH) 3 domain is regulated by the Fyn SH2 domain.Modification of Ser59 in the unique N-terminal region of tyrosine kinase p56lck regulates specificity of its Src homology 2 domain.The tyrosine phosphatase SHP-1 influences thymocyte selection by setting TCR signaling thresholds.SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levelsVisualizing lipid raft dynamics and early signaling events during antigen receptor-mediated B-lymphocyte activation.Zeta chain of the T-cell receptor interacts with nef of simian immunodeficiency virus and human immunodeficiency virus type 2Binding of a diphosphorylated-ITAM peptide to spleen tyrosine kinase (Syk) induces distal conformational changes: a hydrogen exchange mass spectrometry study.Effect of HMG-CoA reductase inhibitors on activation of human gammadeltaT cells induced by Mycobacterium tuberculosis antigens.Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line.Genetic evidence of a role for Lck in T-cell receptor function independent or downstream of ZAP-70/Syk protein tyrosine kinases.
P2860
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P2860
The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
The role of protein tyrosine k ...... receptor signal transduction.
@en
type
label
The role of protein tyrosine k ...... receptor signal transduction.
@en
prefLabel
The role of protein tyrosine k ...... receptor signal transduction.
@en
P2093
P1476
The role of protein tyrosine k ...... receptor signal transduction.
@en
P2093
P304
P356
10.1146/ANNUREV.IY.12.040194.003011
P577
1994-01-01T00:00:00Z