Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line.
about
T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expressionSystematic identification of regulatory proteins critical for T-cell activationFYN-T-FYB-SLP-76 interactions define a T-cell receptor zeta/CD3-mediated tyrosine phosphorylation pathway that up-regulates interleukin 2 transcription in T-cellsPhosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activationT cell regulation of p62(dok) (Dok1) association with Crk-LFunctional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signalingZAP70: a master regulator of adaptive immunityThe importance of three membrane-distal tyrosines in the adaptor protein NTAL/LABMolecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signalingFYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cellsThe tyrosine kinase Lck is a positive regulator of the mitochondrial apoptosis pathway by controlling Bak expressionT cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membraneHIP-55 is important for T-cell proliferation, cytokine production, and immune responsesIn vivo correction of ZAP-70 immunodeficiency by intrathymic gene transferPositive and negative regulation of T-cell activation through kinases and phosphatasesA PAK1-PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT.Coactosin-like 1 antagonizes cofilin to promote lamellipodial protrusion at the immune synapseA novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70The involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T cell activationBiochemical interactions integrating Itk with the T cell receptor-initiated signaling cascadeItk/Emt/Tsk activation in response to CD3 cross-linking in Jurkat T cells requires ZAP-70 and Lat and is independent of membrane recruitmentCytokine-independent Jak3 activation upon T cell receptor (TCR) stimulation through direct association of Jak3 and the TCR complexDocking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory moleculesTyrosine phosphorylation-dependent activation of NF-kappa B. Requirement for p56 LCK and ZAP-70 protein tyrosine kinasesNKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathwayInvolvement of hematopoietic progenitor kinase 1 in T cell receptor signalingLAT, the linker for activation of T cells: a bridge between T cell-specific and general signaling pathwaysCytohesin binder and regulator augments T cell receptor-induced nuclear factor of activated T Cells.AP-1 activation through regulation of the JNK pathwaySLP-76 is a direct substrate of SHP-1 recruited to killer cell inhibitory receptorsThe non-receptor tyrosine kinase Syk is a target of Cbl-mediated ubiquitylation upon B-cell receptor stimulation.Phosphorylation of Tyr342 in the linker region of Syk is critical for Fc epsilon RI signaling in mast cellsPhosphorylation of Syk activation loop tyrosines is essential for Syk function. An in vivo study using a specific anti-Syk activation loop phosphotyrosine antibodyThe Syk family of protein tyrosine kinases in T-cell activation and developmentQuantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hubFunctional independence and interdependence of the Src homology domains of phospholipase C-gamma1 in B-cell receptor signal transduction.The lck SH3 domain is required for activation of the mitogen-activated protein kinase pathway but not the initiation of T-cell antigen receptor signaling.Critical Role for an acidic amino acid region in platelet signaling by the HemITAM (hemi-immunoreceptor tyrosine-based activation motif) containing receptor CLEC-2 (C-type lectin receptor-2).Involvement of LAT, Gads, and Grb2 in compartmentation of SLP-76 to the plasma membranePleiotropic contributions of phospholipase C-gamma1 (PLC-gamma1) to T-cell antigen receptor-mediated signaling: reconstitution studies of a PLC-gamma1-deficient Jurkat T-cell lineResting lymphocyte kinase (Rlk/Txk) targets lymphoid adaptor SLP-76 in the cooperative activation of interleukin-2 transcription in T-cells.
P2860
Q21146439-07C07D32-B8CE-4C43-8210-C41FE6FFA263Q21245890-3FE1408C-1478-461C-8D62-7981DCD85227Q22010396-B4197E8C-F012-4C4C-9EB8-BFC801887FDCQ22254014-ED34277F-2F78-4A19-AEA9-2B85F63C0A9FQ24291680-FFB6DABD-E045-4BE6-9177-BF6A31ED6D1DQ24291874-5210D88F-EB59-44C4-9032-7BF5093C9E82Q24298531-13E51DAA-039B-4427-8906-08D67EE6EFE6Q24304913-ED693CAB-5378-4D33-A77A-DEAD4B230CFEQ24308231-419528C9-8C0F-454B-9483-61D816F2D74EQ24317281-1E618935-BB0C-481D-90F6-F6576CF47204Q24317331-3FF9AE0F-AC5A-434B-A3BB-CC139DB5A7C9Q24319819-2EAC15D7-EEDA-40BF-94B3-69FC18C5C22BQ24529866-C56488DC-D0E0-4ED4-8870-A1B8978ACBF9Q24532255-556F2C41-BC0D-4CAA-AA7B-C81FFFB21D36Q24535649-CB1FBEFB-2FAB-4973-BA99-0324B3844963Q24536674-46D75430-29B5-4363-B036-3F399CF635E0Q27334235-F0B09D75-C875-49E4-BA94-A01F259FE378Q28117849-055B2B27-CB08-47F1-8AF7-72FA068D271FQ28141182-05CA551C-43C5-4354-8910-1995BE41AFF5Q28142714-A0EB4676-1B0C-46EC-981B-D7235A1B0230Q28145381-43B3A75D-BFA7-4C84-B266-1FC7984D2363Q28188446-1BAAAE9D-3297-4D45-83E0-9C3014589A4AQ28188852-C6E0A3F6-8916-4841-B7EA-6420A213FE84Q28202880-DE0684F8-29AF-45F4-A545-53D5ED5923B3Q28203601-74E300FC-51A1-4452-B8EC-E93061683B76Q28208944-DBDE85AF-FB9E-4341-82C1-D58B9B89E425Q28213042-8B109CFA-B0DA-41A9-A4F9-039B3DA8D2F7Q28240316-D9369BA7-8062-4AA2-B636-643AFD4ADB79Q28284908-188DFE47-5A51-4F7A-996A-B31CC99A88BBQ28366332-FD9FC747-52EB-4B20-A977-6D4140A80130Q28567689-DECCC9F8-AC15-4CA3-8A26-E66694118690Q28573020-D6BB21CD-B16D-402A-A7FA-96964B719E35Q28647330-CFC9F3D8-4259-458E-A1B6-2EE63AB81E4DQ28771480-6ACC03A4-199D-4022-ADDF-44A766BCE5F7Q30175330-077AA9B4-8C90-441C-9DDA-69BDA74DA98DQ30175876-CD4E572E-6FEF-47FA-9833-CB55874F6D77Q30583136-B236B769-5F95-4260-B03C-9A73AB58370FQ30655329-C4597FB2-9B94-4091-8B5A-C7C0647B2C12Q33606123-EF550477-12AE-48E3-99E8-DEDA495AA4C4Q33888887-82704241-2785-4302-975E-6E1980B14178
P2860
Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line.
description
1998 nî lūn-bûn
@nan
1998 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի մարտին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Genetic evidence for different ...... -deficient Jurkat T-cell line.
@ast
Genetic evidence for different ...... -deficient Jurkat T-cell line.
@en
type
label
Genetic evidence for different ...... -deficient Jurkat T-cell line.
@ast
Genetic evidence for different ...... -deficient Jurkat T-cell line.
@en
prefLabel
Genetic evidence for different ...... -deficient Jurkat T-cell line.
@ast
Genetic evidence for different ...... -deficient Jurkat T-cell line.
@en
P2093
P2860
P356
P1476
Genetic evidence for different ...... -deficient Jurkat T-cell line.
@en
P2093
B L Williams
K L Schreiber
L E Samelson
P J Leibson
R T Abraham
P2860
P304
P356
10.1128/MCB.18.3.1388
P407
P577
1998-03-01T00:00:00Z