Lysophosphatidic acid stimulates brush border Na+/H+ exchanger 3 (NHE3) activity by increasing its exocytosis by an NHE3 kinase A regulatory protein-dependent mechanism.
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Elevated intracellular calcium stimulates NHE3 activity by an IKEPP (NHERF4) dependent mechanismSp1 and Sp3 control constitutive expression of the human NHE2 promoter by interactions with the proximal promoter and the transcription initiation siteMolecular mechanisms and regulation of urinary acidificationcAMP stimulates apical exocytosis of the renal Na(+)-K(+)-2Cl(-) cotransporter NKCC2 in the thick ascending limb: role of protein kinase ALysophosphatidic acid 5 receptor induces activation of Na(+)/H(+) exchanger 3 via apical epidermal growth factor receptor in intestinal epithelial cellsCytosolic COOH terminus of the peptide transporter PEPT2 is involved in apical membrane localization of the protein.Glucocorticoids acutely increase cell surface Na+/H+ exchanger-3 (NHE3) by activation of NHE3 exocytosis.Luminal Na(+)/H (+) exchange in the proximal tubuleAkt2 phosphorylates ezrin to trigger NHE3 translocation and activationNHE3 mobility in brush borders increases upon NHERF2-dependent stimulation by lyophosphatidic acid.Involvement of threonine 258 and serine 259 motif in amphetamine-induced norepinephrine transporter endocytosis.NHE3 activity is dependent on direct phosphoinositide binding at the N terminus of its intracellular cytosolic region.Transport of influenza virus neuraminidase (NA) to host cell surface is regulated by ARHGAP21 and Cdc42 proteinsLysophosphatidic acid stimulates the intestinal brush border Na(+)/H(+) exchanger 3 and fluid absorption via LPA(5) and NHERF2.Aiming drug discovery at lysophosphatidic acid targets.The NHE3 juxtamembrane cytoplasmic domain directly binds ezrin: dual role in NHE3 trafficking and mobility in the brush border.NHERF1 and NHERF2 are necessary for multiple but usually separate aspects of basal and acute regulation of NHE3 activity.Insulin resistance, obesity, hypertension, and renal sodium transport.Alterations in the proteome of the NHERF2 knockout mouse jejunal brush border membrane vesicles.Cocaine up-regulation of the norepinephrine transporter requires threonine 30 phosphorylation by p38 mitogen-activated protein kinaseChloride channel (Clc)-5 is necessary for exocytic trafficking of Na+/H+ exchanger 3 (NHE3).NHERF2 is necessary for basal activity, second messenger inhibition, and LPA stimulation of NHE3 in mouse distal ileum.Serum- and glucocorticoid-induced kinase 3 in recycling endosomes mediates acute activation of Na+/H+ exchanger NHE3 by glucocorticoids.Nonsynonymous single nucleotide polymorphisms of NHE3 differentially decrease NHE3 transporter activityMechanisms of Intestinal Serotonin Transporter (SERT) Upregulation by TGF-β1 Induced Non-Smad PathwaysAll-trans-retinoic Acid Increases SLC26A3 DRA (Down-regulated in Adenoma) Expression in Intestinal Epithelial Cells via HNF-1βRegulation of ion transport by the NHERF family of PDZ proteins.PDZ proteins retain and regulate membrane transporters in polarized epithelial cell membranes.Evolutionary origins of eukaryotic sodium/proton exchangers.The role of NHERF-1 in the regulation of renal proximal tubule sodium-hydrogen exchanger 3 and sodium-dependent phosphate cotransporter 2a.Mechanisms of DRA recycling in intestinal epithelial cells: effect of enteropathogenic E. coliNHERF2 protein mobility rate is determined by a unique C-terminal domain that is also necessary for its regulation of NHE3 protein in OK cells.Lysophosphatidic acid and renal fibrosis.WNK4 diverts the thiazide-sensitive NaCl cotransporter to the lysosome and stimulates AP-3 interactionAlpha2-adrenergic receptors attenuate secretagogue-induced endocytosis and promote exocytosis of intestinal NHE2 and NHE3.NHERF3 (PDZK1) contributes to basal and calcium inhibition of NHE3 activity in Caco-2BBe cells.Mechanisms of the regulation of the intestinal Na+/H+ exchanger NHE3Regulation of intestinal electroneutral sodium absorption and the brush border Na+/H+ exchanger by intracellular calcium.Role of epithelial ion transports in inflammatory bowel disease.Regulation of dopamine transporter function and cell surface expression by D3 dopamine receptors.
P2860
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P2860
Lysophosphatidic acid stimulates brush border Na+/H+ exchanger 3 (NHE3) activity by increasing its exocytosis by an NHE3 kinase A regulatory protein-dependent mechanism.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Lysophosphatidic acid stimulat ...... y protein-dependent mechanism.
@en
type
label
Lysophosphatidic acid stimulat ...... y protein-dependent mechanism.
@en
prefLabel
Lysophosphatidic acid stimulat ...... y protein-dependent mechanism.
@en
P2093
P2860
P356
P1476
Lysophosphatidic acid stimulat ...... y protein-dependent mechanism.
@en
P2093
Jae Ho Kim
Jung Woong Choi
Kazuya Kawano
Mark Donowitz
Whaseon Lee-Kwon
P2860
P304
16494-16501
P356
10.1074/JBC.M300580200
P407
P577
2003-02-20T00:00:00Z