An optimized polyamine moiety boosts the potency of human type II topoisomerase poisons as quantified by comparative analysis centered on the clinical candidate F14512.
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Synthesis and Biological Evaluation of Novel Aromatic Imide-Polyamine Conjugates.Estimation of kinetic and thermodynamic ligand-binding parameters using computational strategies.The Molecular Basis for Dual Fatty Acid Amide Hydrolase (FAAH)/Cyclooxygenase (COX) Inhibition.Novel Polyamine-Naphthalene Diimide Conjugates Targeting Histone Deacetylases and DNA for Cancer Phenotype Reprogramming.Novel xanthone-polyamine conjugates as catalytic inhibitors of human topoisomerase IIα.Novel Bacterial Topoisomerase Inhibitors Exploit Asp83 and the Intrinsic Flexibility of the DNA Gyrase Binding Site.Polyamine-containing etoposide derivatives as poisons of human type II topoisomerases: Differential effects on topoisomerase IIα and IIβStructural insights into the gating of DNA passage by the topoisomerase II DNA-gate
P2860
Q38727635-912F30D9-B2E6-4D78-9CD6-9A37C341910DQ38737287-44EF137F-B63E-4156-AAC0-9BE232BF65EFQ41454303-93CF0D21-2090-40B0-8611-C81FF3BF6803Q47141661-05068199-85E4-4011-A488-2D8D06088A07Q47789316-3B9865D8-C3C5-4558-A169-A810B60E18AAQ48105075-C1570E06-C8E3-4A21-82AF-300844CDDB78Q56334908-04384C2B-5910-4AEB-A815-253CDA636C16Q58799715-7A7B8E0B-CD8F-4454-891B-AF844DB72F6C
P2860
An optimized polyamine moiety boosts the potency of human type II topoisomerase poisons as quantified by comparative analysis centered on the clinical candidate F14512.
description
2015 nî lūn-bûn
@nan
2015年の論文
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2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
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2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
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2015年论文
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name
An optimized polyamine moiety ...... the clinical candidate F14512.
@en
type
label
An optimized polyamine moiety ...... the clinical candidate F14512.
@en
prefLabel
An optimized polyamine moiety ...... the clinical candidate F14512.
@en
P2093
P2860
P356
P1476
An optimized polyamine moiety ...... the clinical candidate F14512.
@en
P2093
Chiara Marchetti
Claudia Sissi
Elena Simoni
Elirosa Minniti
Laura Riccardi
Marco De Vivo
Maria Laura Greco
Marino Convertino
Michela Rosini
P2860
P304
14310-14313
P356
10.1039/C5CC05065K
P407
P577
2015-08-03T00:00:00Z