RNase L mediates transient control of the interferon response through modulation of the double-stranded RNA-dependent protein kinase PKR.
about
Identification of Apurinic/apyrimidinic endonuclease 1 (APE1) as the endoribonuclease that cleaves c-myc mRNADiverse functions of RNase L and implications in pathologyA scientific journey through the 2-5A/RNase L systemRNase L plays a role in the antiviral response to West Nile virus.A newly discovered function for RNase L in regulating translation terminationRNase L controls terminal adipocyte differentiation, lipids storage and insulin sensitivity via CHOP10 mRNA regulationEndoribonucleases--enzymes gaining spotlight in mRNA metabolism.Sindbis virus translation is inhibited by a PKR/RNase L-independent effector induced by alpha/beta interferon priming of dendritic cellsInterferon-gamma-mediated inhibition of serum response factor-dependent smooth muscle-specific gene expressionEffects of length and location on the cellular response to double-stranded RNA.UU/UA dinucleotide frequency reduction in coding regions results in increased mRNA stability and protein expression.Post-transcriptional control of the interferon system.Regulation of p21/CIP1/WAF-1 mediated cell-cycle arrest by RNase L and tristetraprolin, and involvement of AU-rich elements.Human RNase L tunes gene expression by selectively destabilizing the microRNA-regulated transcriptome.Ribosomal protein mRNAs are primary targets of regulation in RNase-L-induced senescence.Defects in TLR3 expression and RNase L activation lead to decreased MnSOD expression and insulin resistance in muscle cells of obese people.RNase-L control of cellular mRNAs: roles in biologic functions and mechanisms of substrate targeting.Viruses and the cellular RNA decay machinery.Can't RIDD off viruses.Post-transcriptional control of cytokine gene expression in health and disease.Enhancers of adeno-associated virus AAV2 transduction via high throughput siRNA screening.Regulation of mitochondrial mRNA stability by RNase L is translation-dependent and controls IFNalpha-induced apoptosis.Involvement of the interferon-regulated antiviral proteins PKR and RNase L in reovirus-induced shutoff of cellular translation.A versatile ribosomal protein promoter-based reporter system for selective assessment of RNA stability and post-transcriptional controlRNase L downmodulation of the RNA-binding protein, HuR, and cellular growth
P2860
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P2860
RNase L mediates transient control of the interferon response through modulation of the double-stranded RNA-dependent protein kinase PKR.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
RNase L mediates transient con ...... -dependent protein kinase PKR.
@en
type
label
RNase L mediates transient con ...... -dependent protein kinase PKR.
@en
prefLabel
RNase L mediates transient con ...... -dependent protein kinase PKR.
@en
P2093
P2860
P50
P356
P1476
RNase L mediates transient con ...... A-dependent protein kinase PKR
@en
P2093
Aimin Zhou
Beihua Dong
Fahad al-Zoghaibi
Futwan Al-Mohanna
Jayashree Paranjape
Latifa al-Haj
Mark Whitmore
Mohammed Dhalla
Mohammed N Al-Ahdal
Yunus M Siddiqui
P2860
P304
20124-20132
P356
10.1074/JBC.M208766200
P407
P577
2003-02-11T00:00:00Z