The codon 72 polymorphic variants of p53 have markedly different apoptotic potential.
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Monoubiquitylation promotes mitochondrial p53 translocationHsp60 regulation of tumor cell apoptosisMitochondrial ribosomal protein L41 suppresses cell growth in association with p53 and p27Kip1.MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathwayLoss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosisComparative analysis of cancer genes in the human and chimpanzee genomes.p53 acetylation is crucial for its transcription-independent proapoptotic functionsSingle-nucleotide polymorphisms in the p53 pathway regulate fertility in humansTwo faces of p53: aging and tumor suppressionHepatitis B virus replication is associated with an HBx-dependent mitochondrion-regulated increase in cytosolic calcium levelsRegulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanismIn B-CLL, the codon 72 polymorphic variants of p53 are not related to drug resistance and disease prognosisOncogenic Intra-p53 Family Member Interactions in Human CancersAlterations in Mitochondrial and Endoplasmic Reticulum Signaling by p53 MutantsAlterations of the TP53 gene in gastric and esophageal carcinogenesisUncovering the role of p53 splice variants in human malignancy: a clinical perspectiveTP53 mutation in patients with high-risk acute myeloid leukaemia treated with allogeneic haematopoietic stem cell transplantation.The role of the p53 tumor suppressor in metabolism and diabetesFatal liaisons of p53 with Bax and Bakp53 polymorphisms associated with mutations in and loss of heterozygosity of the p53 gene in male oral squamous cell carcinomas in TaiwanGene polymorphisms predict toxicity to neoadjuvant therapy in patients with rectal cancerThe dose window for radiation-induced protective adaptive responsesInteraction of OKL38 and p53 in regulating mitochondrial structure and functionThe Pro allele of the p53 codon 72 polymorphism is associated with decreased intratumoral expression of BAX and p21, and increased breast cancer riskp73 as a pharmaceutical target for cancer therapyEffects of prostaglandin E2 on p53 mRNA transcription and p53 mutagenesis during T-cell-independent human B-cell clonal expansionAssociation between TP53 gene Arg72Pro polymorphism and Wilms' tumor risk in a Chinese population.International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathwaysCSF1 is a novel p53 target gene whose protein product functions in a feed-forward manner to suppress apoptosis and enhance p53-mediated growth arrest.Defining the p53 DNA-binding domain/Bcl-x(L)-binding interface using NMR.Importance of TP53 codon 72 and intron 3 duplication 16bp polymorphisms in prediction of susceptibility on breast cancerHaplotype analysis of TP53 polymorphisms, Arg72Pro and Ins16, in BRCA1 and BRCA2 mutation carriers of French Canadian descent.MDM2 gene SNP309 T/G and p53 gene SNP72 G/C do not influence diffuse large B-cell non-Hodgkin lymphoma onset or survival in central European CaucasiansTP63 and TP73 in cancer, an unresolved "family" puzzle of complexity, redundancy and hierarchy.Association of the germline TP53 R337H mutation with breast cancer in southern Brazil.Highly variable response to cytotoxic chemotherapy in carcinoma-associated fibroblasts (CAFs) from lung and breast.Association of DRD4 uVNTR and TP53 codon 72 polymorphisms with schizophrenia: a case-control studyGenetic polymorphisms of MDM2 and TP53 genes are associated with risk of nasopharyngeal carcinoma in a Chinese population.The TP53 gene rs1042522 C>G polymorphism and neuroblastoma risk in Chinese children.Lack of association of the TP53 Arg72Pro SNP and the MDM2 SNP309 with systemic lupus erythematosus in Caucasian, African American, and Asian children and adults.
P2860
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P2860
The codon 72 polymorphic variants of p53 have markedly different apoptotic potential.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
The codon 72 polymorphic variants of p53 have markedly different apoptotic potential.
@en
type
label
The codon 72 polymorphic variants of p53 have markedly different apoptotic potential.
@en
prefLabel
The codon 72 polymorphic variants of p53 have markedly different apoptotic potential.
@en
P2093
P356
P1433
P1476
The codon 72 polymorphic variants of p53 have markedly different apoptotic potential.
@en
P2093
Anthony C Della Pietra
Donna L George
J I-Ju Leu
Patrick Dumont
P2888
P304
P356
10.1038/NG1093
P407
P577
2003-02-03T00:00:00Z
P5875
P6179
1003113338