On the nature of partial agonism in the nicotinic receptor superfamily.
about
End-plate acetylcholine receptor: structure, mechanism, pharmacology, and diseaseStructure, function, and modulation of GABA(A) receptorsDecrypting the sequence of structural events during the gating transition of pentameric ligand-gated ion channels based on an interpolated elastic network modelStructural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal α7 nicotinic acetylcholine receptorOne-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologueLigand Activation of the Prokaryotic Pentameric Ligand-Gated Ion Channel ELICMolecular actions of smoking cessation drugs at 4 2 nicotinic receptors defined in crystal structures of a homologous binding proteinActivation of endplate nicotinic acetylcholine receptors by agonistsAllosteric activation mechanism of the cys-loop receptorsHighly fatal fast-channel syndrome caused by AChR ε subunit mutation at the agonist binding siteMolecular sites for the positive allosteric modulation of glycine receptors by endocannabinoidsA linear framework for time-scale separation in nonlinear biochemical systemsDynamics of T-Junction Solution Switching Aimed at Patch Clamp ExperimentsMurine startle mutant Nmf11 affects the structural stability of the glycine receptor and increases deactivation.Energy and structure of the M2 helix in acetylcholine receptor-channel gating.Molecular requirements for ethanol differential allosteric modulation of glycine receptors based on selective Gbetagamma modulation.The swipe card model of odorant recognitionHigh intracellular chloride slows the decay of glycinergic currents.Achieving maximal speed of solution exchange for patch clamp experiments.Identification of a pre-active conformation of a pentameric channel receptorThe activation mechanism of alpha1beta2gamma2S and alpha3beta3gamma2S GABAA receptors.Conformational changes in the nicotinic acetylcholine receptor during gating and desensitizationCoupling and cooperativity in voltage activation of a limited-state BK channel gating in saturating Ca2+.Relationships between structural dynamics and functional kinetics in oligomeric membrane receptorsCatch-and-hold activation of muscle acetylcholine receptors having transmitter binding site mutationsLinking the acetylcholine receptor-channel agonist-binding sites with the gateEfficient maximum likelihood estimation of kinetic rate constants from macroscopic currentsPharmacological characterization of the allosteric modulator desformylflustrabromine and its interaction with alpha4beta2 neuronal nicotinic acetylcholine receptor orthosteric ligands.Nicotinic acetylcholine receptor and the structural basis of neuromuscular transmission: insights from Torpedo postsynaptic membranesProbability fluxes and transition paths in a Markovian model describing complex subunit cooperativity in HCN2 channelsPartial agonism of taurine at gamma-containing native and recombinant GABAA receptorsFlapping loops: roles for hinges in a ligand-binding domain of the nicotinic receptor.A cation-π interaction at a phenylalanine residue in the glycine receptor binding site is conserved for different agonists.Detection and trapping of intermediate states priming nicotinic receptor channel opening.Single-channel kinetics of BK (Slo1) channels.Energetic contributions to channel gating of residues in the muscle nicotinic receptor β1 subunit.Subunit interfaces contribute differently to activation and allosteric modulation of neuronal nicotinic acetylcholine receptors.Conformational changes in acetylcholine binding protein investigated by temperature accelerated molecular dynamics.Desensitization of alpha7 nicotinic receptor is governed by coupling strength relative to gate tightnessAgonist-specific gating of NMDA receptors.
P2860
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P2860
On the nature of partial agonism in the nicotinic receptor superfamily.
description
2008 nî lūn-bûn
@nan
2008 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
On the nature of partial agonism in the nicotinic receptor superfamily.
@ast
On the nature of partial agonism in the nicotinic receptor superfamily.
@en
On the nature of partial agonism in the nicotinic receptor superfamily.
@nl
type
label
On the nature of partial agonism in the nicotinic receptor superfamily.
@ast
On the nature of partial agonism in the nicotinic receptor superfamily.
@en
On the nature of partial agonism in the nicotinic receptor superfamily.
@nl
altLabel
On the nature of partial agonism in the nicotinic receptor superfamily
@en
prefLabel
On the nature of partial agonism in the nicotinic receptor superfamily.
@ast
On the nature of partial agonism in the nicotinic receptor superfamily.
@en
On the nature of partial agonism in the nicotinic receptor superfamily.
@nl
P2860
P356
P1433
P1476
On the nature of partial agonism in the nicotinic receptor superfamily.
@en
P2093
David Colquhoun
Remigijus Lape
P2860
P2888
P304
P356
10.1038/NATURE07139
P407
P577
2008-07-16T00:00:00Z
P5875
P6179
1023388624