Behavior in the eukaryotic secretory pathway of insulin-containing fusion proteins and single-chain insulins bearing various B-chain mutations.
about
A role for Lte1p (a low temperature essential protein involved in mitosis) in proprotein processing in the yeast secretory pathwayInefficient translocation of preproinsulin contributes to pancreatic β cell failure and late-onset diabetes.Mutant INS-gene induced diabetes of youth: proinsulin cysteine residues impose dominant-negative inhibition on wild-type proinsulin transportProinsulin misfolding and diabetes: mutant INS gene-induced diabetes of youth.A model of threshold behavior reveals rescue mechanisms of bystander proteins in conformational diseasesProinsulin and the genetics of diabetes mellitusProinsulin misfolding and endoplasmic reticulum stress during the development and progression of diabetes.Impaired cleavage of preproinsulin signal peptide linked to autosomal-dominant diabetesProinsulin disulfide maturation and misfolding in the endoplasmic reticulumDiabetes mellitus due to the toxic misfolding of proinsulin variants.Metabolic engineering of recombinant protein secretion by Saccharomyces cerevisiae.Degradation of mutated bovine pancreatic trypsin inhibitor in the yeast vacuole suggests post-endoplasmic reticulum protein quality control.Different expression systems for production of recombinant proteins in Saccharomyces cerevisiaeA conserved histidine in insulin is required for the foldability of human proinsulin: structure and function of an ALAB5 analog.Role of the connecting peptide in insulin biosynthesis.Proinsulin lacking the A7-B7 disulfide bond, Ins2Akita, tends to aggregate due to the exposed hydrophobic surface.Insulin-like peptide 3 expressed in the silkworm possesses intrinsic disulfide bonds and full biological activity.Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes.
P2860
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P2860
Behavior in the eukaryotic secretory pathway of insulin-containing fusion proteins and single-chain insulins bearing various B-chain mutations.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Behavior in the eukaryotic sec ...... ing various B-chain mutations.
@en
type
label
Behavior in the eukaryotic sec ...... ing various B-chain mutations.
@en
prefLabel
Behavior in the eukaryotic sec ...... ing various B-chain mutations.
@en
P2093
P2860
P356
P1476
Behavior in the eukaryotic sec ...... ing various B-chain mutations.
@en
P2093
Bao-yan Zhang
Peter Arvan
P2860
P304
P356
10.1074/JBC.M209474200
P407
P577
2002-11-21T00:00:00Z