Impaired cleavage of preproinsulin signal peptide linked to autosomal-dominant diabetes - Wikidata - awgldk - TriplyDB

Impaired cleavage of preproinsulin signal peptide linked to autosomal-dominant diabetes

Impaired cleavage of preproinsulin signal peptide linked to autosomal-dominant diabetes

http://www.wikidata.org/entity/Q35857741

about

INS-gene mutations: from genetics and beta cell biology to clinical disease Inefficient translocation of preproinsulin contributes to pancreatic β cell failure and late-onset diabetes.Amyloidogenic peptide oligomer accumulation in autophagy-deficient β cells induces diabetes.Proinsulin misfolding and endoplasmic reticulum stress during the development and progression of diabetes.PDI reductase acts on Akita mutant proinsulin to initiate retrotranslocation along the Hrd1/Sel1L-p97 axis.Competitive Inhibition of the Endoplasmic Reticulum Signal Peptidase by Non-cleavable Mutant Preprotein Cargos Proinsulin intermolecular interactions during secretory trafficking in pancreatic β cells Disulfide Mispairing During Proinsulin Folding in the Endoplasmic Reticulum.miR-25 and miR-92a regulate insulin I biosynthesis in rats.Endoplasmic reticulum oxidoreductin-1α (Ero1α) improves folding and secretion of mutant proinsulin and limits mutant proinsulin-induced endoplasmic reticulum stress.Calcium efflux from the endoplasmic reticulum leads to β-cell death.Signal peptides: new markers in cardiovascular disease?Apoptosis, autophagy & endoplasmic reticulum stress in diabetes mellitus.Positive charge in the n-region of the signal peptide contributes to efficient post-translational translocation of small secretory preproteins.Insight into the Pathology of a COL1A1 Signal Peptide Heterozygous Mutation Leading to Severe Osteogenesis Imperfecta.Comprehensive screening for monogenic diabetes in 89 Japanese children with insulin-requiring antibody-negative type 1 diabetes.Six cases with severe insulin resistance (SIR) associated with mutations of insulin receptor: Is a Bartter-like syndrome a feature of congenital SIR?Improved secretory expression of lignocellulolytic enzymes in by promoter and signal sequence engineering

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Impaired cleavage of preproinsulin signal peptide linked to autosomal-dominant diabetes

http://www.wikidata.org/entity/Q35857741

description

2012 nî lūn-bûn

@nan

2012年の論文

@ja

2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

2012年论文

@zh

2012年论文

@zh-cn

name

Impaired cleavage of preproinsulin signal peptide linked to autosomal-dominant diabetes

@ast

Impaired cleavage of preproinsulin signal peptide linked to autosomal-dominant diabetes

@en

type

label

Impaired cleavage of preproinsulin signal peptide linked to autosomal-dominant diabetes

@ast

Impaired cleavage of preproinsulin signal peptide linked to autosomal-dominant diabetes

@en

prefLabel

Impaired cleavage of preproinsulin signal peptide linked to autosomal-dominant diabetes

@ast

Impaired cleavage of preproinsulin signal peptide linked to autosomal-dominant diabetes

@en

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P1476

Impaired cleavage of preproinsulin signal peptide linked to autosomal-dominant diabetes

@en

P2093

Dennis Larkin

http://www.w3.org/2001/XMLSchema#string

Huan Guo

http://www.w3.org/2001/XMLSchema#string

Leena Haataja

http://www.w3.org/2001/XMLSchema#string

Ming Liu

http://www.w3.org/2001/XMLSchema#string

Peter Arvan

http://www.w3.org/2001/XMLSchema#string

Shu-ou Shan

http://www.w3.org/2001/XMLSchema#string

P2860

ERO1-beta, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis

Substrate-specific translocational attenuation during ER stress defines a pre-emptive quality control pathway.

Further evidence that mutations in INS can be a rare cause of Maturity-Onset Diabetes of the Young (MODY).

Misfolded proinsulin affects bystander proinsulin in neonatal diabetes

Insulin gene mutations resulting in early-onset diabetes: marked differences in clinical presentation, metabolic status, and pathogenic effect through endoplasmic reticulum retention.

Contribution of residue B5 to the folding and function of insulin and IGF-I: constraints and fine-tuning in the evolution of a protein family.

Mutant INS-gene induced diabetes of youth: proinsulin cysteine residues impose dominant-negative inhibition on wild-type proinsulin transport

In vitro processing and secretion of mutant insulin proteins that cause permanent neonatal diabetes.

Recessive mutations in the INS gene result in neonatal diabetes through reduced insulin biosynthesis.

PERK (EIF2AK3) regulates proinsulin trafficking and quality control in the secretory pathway.

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828-837

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scholarly article

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10.2337/DB11-0878

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4

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61

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Fabrizio Barbetti

Roberto Lara-Lemus

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2012-02-22T00:00:00Z

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221854585

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22357960

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3314357

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