Regulation of NOTCH signaling by reciprocal inhibition of HES1 and Deltex 1 and its role in osteosarcoma invasiveness.
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Regulating Axonal Responses to Injury: The Intersection between Signaling Pathways Involved in Axon Myelination and The Inhibition of Axon RegenerationUnderstanding the Biology of Bone Sarcoma from Early Initiating Events through Late Events in Metastasis and Disease ProgressionManic fringe inhibits tumor growth by suppressing Notch3 degradation in lung cancerT cell development requires constraint of the myeloid regulator C/EBP-α by the Notch target and transcriptional repressor Hes1.Metformin sensitizes chemotherapy by targeting cancer stem cells and the mTOR pathway in esophageal cancerInitial testing (stage 1) of the notch inhibitor PF-03084014, by the pediatric preclinical testing program.New partner proteins containing novel internal recognition motif for human glutaminase interacting protein (hGIP).Deltex-1 activates mitotic signaling and proliferation and increases the clonogenic and invasive potential of U373 and LN18 glioblastoma cells and correlates with patient survivalHES1, a target of Notch signaling, is elevated in canine osteosarcoma, but reduced in the most aggressive tumorsNew, tolerable γ-secretase inhibitor takes desmoid down a notch.Inhibition of the Notch-Hey1 axis blocks embryonal rhabdomyosarcoma tumorigenesis.Initial testing (stage 1) by the pediatric preclinical testing program of RO4929097, a γ-secretase inhibitor targeting notch signaling.Hes1: a key role in stemness, metastasis and multidrug resistance.Deltex1 is inhibited by the Notch-Hairy/E(Spl) signaling pathway and induces neuronal and glial differentiation.Anti-tumor effects of the Notch pathway in gastrointestinal stromal tumorsEpigallocatechin gallate inhibits the proliferation of colorectal cancer cells by regulating Notch signaling.Notch Signaling is Associated with ALDH Activity and an Aggressive Metastatic Phenotype in Murine Osteosarcoma CellsTherapeutic effect of γ-secretase inhibition in KrasG12V-driven non-small cell lung carcinoma by derepression of DUSP1 and inhibition of ERKNotch signaling in skeletal stem cells.Genetic variants of genes in the Notch signaling pathway predict overall survival of non-small cell lung cancer patients in the PLCO study.MiR-34a-5p promotes multi-chemoresistance of osteosarcoma through down-regulation of the DLL1 gene.Laminar flow downregulates Notch activity to promote lymphatic sprouting.The multiple facets of ubiquitination in the regulation of notch signaling pathway.Notch regulation of tumor angiogenesis.Pericytes in sarcomas of bone.Integrative computational analysis of transcriptional and epigenetic alterations implicates DTX1 as a putative tumor suppressor gene in HNSCCMiR-182 promotes cancer invasion by linking RET oncogene activated NF-κB to loss of the HES1/Notch1 regulatory circuit.HES1 promotes metastasis and predicts poor survival in patients with colorectal cancer.Inhibition of the Wnt-β-catenin and Notch signaling pathways sensitizes osteosarcoma cells to chemotherapy.Notch-mediated induction of N-cadherin and α9-integrin confers higher invasive phenotype on rhabdomyosarcoma cellsMiR-155 is a liposarcoma oncogene that targets casein kinase-1α and enhances β-catenin signaling.Dysfunctional transforming growth factor-β signaling with constitutively active Notch signaling in Barrett's esophageal adenocarcinoma.Aberrant expression of Notch1, HES1, and DTX1 genes in glioblastoma formalin-fixed paraffin-embedded tissues.The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling.Aberrant ADAM10 expression correlates with osteosarcoma progression.Mechanism of BMP9 promotes growth of osteosarcoma mediated by the Notch signaling pathway.Loss of TGF-β adaptor β2SP activates notch signaling and SOX9 expression in esophageal adenocarcinoma.Gamma-secretase inhibitors target tumor-initiating cells in a mouse model of ERBB2 breast cancer.PI5P4Kγ functions in DTX1-mediated Notch signaling.Up-regulation of microRNA-340 promotes osteosarcoma cell apoptosis while suppressing proliferation, migration, and invasion by inactivating the CTNNB1-mediated Notch signaling pathway
P2860
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P2860
Regulation of NOTCH signaling by reciprocal inhibition of HES1 and Deltex 1 and its role in osteosarcoma invasiveness.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Regulation of NOTCH signaling ...... in osteosarcoma invasiveness.
@en
type
label
Regulation of NOTCH signaling ...... in osteosarcoma invasiveness.
@en
prefLabel
Regulation of NOTCH signaling ...... in osteosarcoma invasiveness.
@en
P2093
P2860
P356
P1433
P1476
Regulation of NOTCH signaling ...... in osteosarcoma invasiveness.
@en
P2093
P2860
P2888
P304
P356
10.1038/ONC.2010.62
P407
P577
2010-03-08T00:00:00Z
P5875
P6179
1045385506