Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling.
about
The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3Muscle atrophy in transgenic mice expressing a human TSC1 transgeneInsulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1/TSC2 in C2C12 myotubesRegulation of TSC2 by 14-3-3 bindingUpregulation of the mammalian target of rapamycin complex 1 pathway by Ras homolog enriched in brain in pancreatic beta-cells leads to increased beta-cell mass and prevention of hyperglycemiaSignaling by target of rapamycin proteins in cell growth controlRegulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complexAmino acids as regulators of gene expressionBiochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activityDisruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell developmentUpdates of mTOR inhibitorsSpatial regulation of the mTORC1 system in amino acids sensing pathwayThe tuberous sclerosis complexAn emerging role for TOR signaling in mammalian tissue and stem cell physiologyRegulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathwayThe TSC1-TSC2 complex: a molecular switchboard controlling cell growthRecent advances in understanding leptin signaling and leptin resistanceRheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signalingBalancing Akt with S6K: implications for both metabolic diseases and tumorigenesisA MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signallingIdentification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size controlExpression of Drosophila FOXO regulates growth and can phenocopy starvationThe Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signalingAmino Acid Sensing by mTORC1: Intracellular Transporters Mark the SpotRegulation of mTORC1 by PI3K signalingPhosphoinositides: tiny lipids with giant impact on cell regulationNutrient regulation of the mTOR complex 1 signaling pathwayCyclin G Functions as a Positive Regulator of Growth and Metabolism in DrosophilaGrowth-Blocking Peptides As Nutrition-Sensitive Signals for Insulin Secretion and Body Size RegulationTor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae.A genome-wide screen for regulators of TORC1 in response to amino acid starvation reveals a conserved Npr2/3 complexA Subset of Autism-Associated Genes Regulate the Structural Stability of Neurons.Left-right asymmetry in the light of TOR: An update on what we know so farThe GATOR2 Component Wdr24 Regulates TORC1 Activity and Lysosome FunctionRheb is a direct target of the tuberous sclerosis tumour suppressor proteinsCell cycle-regulated phosphorylation of hamartin, the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1/cyclin BPam and its ortholog highwire interact with and may negatively regulate the TSC1.TSC2 complexThe tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stressesmTOR/p70S6k signalling alteration by Abeta exposure as well as in APP-PS1 transgenic models and in patients with Alzheimer's diseaseRegulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent
P2860
Q24294590-BD122D27-A82B-41CC-B6EA-6706C8FC0BD1Q24304304-72C81B06-BB9A-439B-A3FB-987F6B9A7F57Q24307579-ABA3730B-2C20-499E-A4F1-0753DC8C79A0Q24308785-C662255F-3FCC-4581-AB6D-F19116A5A3B9Q24317018-3C66D2EC-DAA6-445D-AA62-92328226016BQ24522447-4F5B0B07-2300-4757-8E2B-493F9B01D72EQ24559347-C7A24E8C-F5A4-434B-B9E7-6231D5546177Q24562847-AE62168C-10B2-4446-8C5B-EB98FFFAF5EFQ24563018-1A31BE65-D87C-43BE-A3EE-DD9FC7FFDBF2Q24563399-5CDBEFED-FAB6-4A6C-93DB-0DA81DF42B2EQ24607170-A9B34FE4-09B7-49ED-BAD4-AEC71DA576DCQ24612853-A6AED242-D199-423F-8EAD-3A4FBEEF2472Q24628011-9657B313-25F0-4653-9BBA-18F114E49350Q24629305-8A985422-BC7F-4E8E-88DB-14F8C12AB109Q24643816-8E22B4A3-6BE3-435E-B3F3-C9B7601F11F0Q24645204-6678DC88-EAE6-42F0-970B-D5138BDE1C6CQ24658188-8BA08F72-6E60-43D9-A0D7-2882D1B907B0Q24672005-FC48D286-9808-4345-B491-66FA6EE94272Q24676203-E283C43A-0A65-45E3-A5A0-2B111714F9D8Q24678327-A8B3F71D-6B45-4BDD-AF7F-976EE11F3960Q24679076-952D34C2-15EB-46A7-9B0B-A6F3AD250FA3Q24794099-11201375-2A5D-4147-8B11-6BBE7A63BE09Q24794823-BC909400-FE23-43D5-9209-4E279EA13396Q26748629-411377CA-2FAC-4A16-992C-E1422E1B9C37Q26995791-214C6134-3BD0-4986-884F-D32A3CBE3F21Q27012953-46C33DE4-F073-4B53-A46E-BF6E848D1CA7Q27027823-6D5560F3-9666-4FBF-B28A-BE2C3AF32865Q27310439-80ACF365-F3EC-4901-B46A-5538F5D3D2CBQ27345150-94C4F83F-8043-4E3F-B863-9A2A88D3BA20Q27931595-833500C7-762E-4AE5-86B2-E234ACCF7075Q27938995-D8628209-F5AC-4C25-96CF-473D09A59953Q28079929-C5DD51CC-FB2E-4485-B70C-7084B91A210BQ28080826-59D12732-3843-42AB-B448-66C83A51F84EQ28115362-5D70EAD3-B60B-4E07-B170-3B946FEF36D7Q28207283-ACB7C673-6B8A-4418-83F9-AABE6E48BA92Q28208783-319C44C4-5CCB-4A36-8901-A610C1D061B0Q28209980-6B43F15E-C2A2-400F-98AE-D29F3FA172D9Q28240102-DEDD2E2B-5F17-4511-B0E1-2E84C9A0E0D8Q28256208-B20497B1-CB3B-4406-ADBF-EB4D53AD02D1Q28262376-0703DC59-10DE-44E0-8DB1-4C4CE1060C6A
P2860
Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling.
@en
type
label
Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling.
@en
prefLabel
Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling.
@en
P2093
P2860
P356
P1433
P1476
Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling.
@en
P2093
Binggeng Ru
Duojia Pan
Peter Arrazola
Raymond S Yeung
Toshiyuki Kobayashi
Xinsheng Gao
Yong Zhang
P2860
P2888
P304
P356
10.1038/NCB847
P577
2002-09-01T00:00:00Z
P6179
1041558211