An essential role of N-terminal arginylation in cardiovascular development.
about
A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons.The N-end rule pathwayMouse Dfa is a repressor of TATA-box promoters and interacts with the Abt1 activator of basal transcriptionDiscovery of cellular regulation by protein degradationDiversity of degradation signals in the ubiquitin-proteasome systemFemale lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathwaySynthetic heterovalent inhibitors targeting recognition E3 components of the N-end rule pathwayPerspectives and Insights into the Competition for Aminoacyl-tRNAs between the Translational Machinery and for tRNA Dependent Non-Ribosomal Peptide Bond FormationConditional Tek promoter-driven deletion of arginyltransferase in the germ line causes defects in gametogenesis and early embryonic lethality in miceArginylation-dependent neural crest cell migration is essential for mouse developmentStructural basis of substrate recognition and specificity in the N-end rule pathwayA ketosynthase homolog uses malonyl units to form esters in cervimycin biosynthesisAmino acids induce peptide uptake via accelerated degradation of CUP9, the transcriptional repressor of the PTR2 peptide transporter.Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome)Global analysis of posttranslational protein arginylation.The ubiquitin ligase Ubr2, a recognition E3 component of the N-end rule pathway, stabilizes Tex19.1 during spermatogenesisIdentification of mammalian arginyltransferases that modify a specific subset of protein substratesLiat1, an arginyltransferase-binding protein whose evolution among primates involved changes in the numbers of its 10-residue repeatsGlutamine-specific N-terminal amidase, a component of the N-end rule pathwayBiochemical and genetic studies of UBR3, a ubiquitin ligase with a function in olfactory and other sensory systemsUBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitinationEvolutionary distinctiveness of fatty acid and polyketide synthesis in eukaryotesPlant cysteine oxidases are dioxygenases that directly enable arginyl transferase-catalysed arginylation of N-end rule targets.Generation of Artificial N-end Rule Substrate Proteins In Vivo and In Vitro.An improved workflow for quantitative N-terminal charge-based fractional diagonal chromatography (ChaFRADIC) to study proteolytic events in Arabidopsis thaliana.Arginylation regulates intracellular actin polymer level by modulating actin properties and binding of capping and severing proteins.The substrate recognition domains of the N-end rule pathway.Arginyltransferase regulates alpha cardiac actin function, myofibril formation and contractility during heart development.Small molecule inhibitors of arginyltransferase regulate arginylation-dependent protein degradation, cell motility, and angiogenesisAblation of arginylation in the mouse N-end rule pathway: loss of fat, higher metabolic rate, damaged spermatogenesis, and neurological perturbations.Gamma 2 subunit of G protein heterotrimer is an N-end rule ubiquitylation substrate.A novel form of neurotensin post-translationally modified by arginylation.The N-end rule pathway controls multiple functions during Arabidopsis shoot and leaf development.Plant arginyltransferases (ATEs).The anti-apoptotic form of tyrosine kinase Lyn that is generated by proteolysis is degraded by the N-end rule pathway.RGS4, a GTPase activator, improves renal function in ischemia-reperfusion injury.Arginylation of myosin heavy chain regulates skeletal muscle strengthUbiquitin ligases of the N-end rule pathway: assessment of mutations in UBR1 that cause the Johanson-Blizzard syndromeProtein arginylation, a global biological regulator that targets actin cytoskeleton and the muscleRGS4 and RGS5 are in vivo substrates of the N-end rule pathway
P2860
Q24529893-C614F34A-C18F-44FD-BD97-ED6FFDCDBB8AQ24598290-7FECF9A0-5DDC-4FA2-BEF8-2F9B708154B6Q24603948-AEB09F14-1A4E-4AF6-B1B2-F17169715E6BQ24607508-CBE6E387-64C9-4905-95D3-C860A7BA5F21Q24642979-3400F2A0-5FBE-4DBC-BE3A-9DC8A7DCFF6BQ24649866-EDA24F3D-CA03-4D69-9978-D2C9ACA1EDAAQ24657529-2A797DDB-A964-48C4-8255-F9A58E5DB565Q26771234-57433B97-EFE6-4EF4-9528-099671370817Q27335779-ACAA412E-C55D-402E-AB3D-76700EE2ED53Q27348001-AC75E552-FF4E-4C74-973B-91CC8EA48230Q27664443-A29C16B3-3D95-4872-9ED0-784864615B8CQ27676281-5FAAD6FE-8049-4AAB-A6F1-3BA3F6B38277Q27938697-06F80ACC-F765-4CF8-92A3-78B77379AA77Q28283899-5593C62D-B088-4B57-8D78-99ED5AB2AD0FQ28469307-B8870958-30D8-4FA8-912E-6C75A8AF7A29Q28476173-E41CD4C2-6F77-4DC7-9883-CCE0B88E1755Q28507776-AB7C80EE-2956-46A9-8593-00AA06DBB3ECQ28510458-F0E691F0-F8A7-4BA8-9B79-4DCEAD65F820Q28591063-BD8C1EA9-E667-453F-836E-6013B6AB6F30Q28594626-E3CD4603-52A1-4F9F-9ACE-CF698BDFACB6Q28594993-2F2C9EA7-2FC6-420B-9F92-C5E554F2CC60Q28829673-41682F25-90C2-4A1A-B133-DE31C092C5D7Q30313311-6C60BE0C-71EF-4219-AF69-04666BCD82D3Q30314019-4F8936C0-30C5-4E02-B87D-665CF66204B7Q30316527-B016D48C-CA56-4097-8AC9-5A66E786A7E3Q30435749-52E5A0AD-3600-4A3B-ACA9-5001F30FEF14Q30437353-93927C01-B842-46D4-B08D-5C2F6E2C7AFEQ30484509-ECD5B8FE-7960-4F72-8BBF-BC1CC38B60D0Q30505748-6AE9CB39-A274-468D-AF47-187FCDB2D7C8Q30886015-5EF69EF8-E335-49EA-B365-41AAC79918FCQ31138692-F8D0703E-E341-44B6-AFD9-83E02744EAE5Q33221326-43BA3281-B655-462F-BB68-D08CF1EB094CQ33347443-85900BDF-1295-4A5B-9160-DC1B64838330Q33749108-76F0750C-B615-4E94-B51A-96338EB02A5AQ33757090-39872A31-0A0B-4732-8E0B-BE54A6B69186Q33848879-1E082538-28E1-469A-AE1F-7637FB4E8265Q34020630-0C5888EE-9994-45D8-ABC8-6F76D39C9163Q34024105-F38CF5D0-1869-4B12-97E2-ECF3478249C9Q34055687-A0300B59-121C-474C-B9DB-7CEFA1C95119Q34085136-698F13BB-DD6D-4C45-8F3D-813B9CC3D4ED
P2860
An essential role of N-terminal arginylation in cardiovascular development.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
An essential role of N-terminal arginylation in cardiovascular development.
@en
type
label
An essential role of N-terminal arginylation in cardiovascular development.
@en
prefLabel
An essential role of N-terminal arginylation in cardiovascular development.
@en
P2093
P356
P1433
P1476
An essential role of N-terminal arginylation in cardiovascular development.
@en
P2093
Alexander Varshavsky
Anna S Kashina
Fangyong Du
Ilia V Davydov
Jai Wha Seo
Jee Young An
Rong-Gui Hu
Yong Tae Kwon
P356
10.1126/SCIENCE.1069531
P407
P577
2002-07-01T00:00:00Z