The long and short isoforms of Ret function as independent signaling complexes.
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GDNF-Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson diseaseCD2-associated protein (CD2AP) enhances casitas B lineage lymphoma-3/c (Cbl-3/c)-mediated Ret isoform-specific ubiquitination and degradation via its amino-terminal Src homology 3 domains.Distinct turnover of alternatively spliced isoforms of the RET kinase receptor mediated by differential recruitment of the Cbl ubiquitin ligase.Organotypic specificity of key RET adaptor-docking sites in the pathogenesis of neurocristopathies and renal malformations in mice.The differential axonal degradation of Ret accounts for cell-type-specific function of glial cell line-derived neurotrophic factor as a retrograde survival factor.Gas1 is related to the glial cell-derived neurotrophic factor family receptors alpha and regulates Ret signaling.A human yeast artificial chromosome containing the multiple endocrine neoplasia type 2B Ret mutation does not induce medullary thyroid carcinoma but does support the growth of kidneys and partially rescues enteric nervous system development in Ret-dThe influence of Hox genes and three intercellular signalling pathways on enteric neuromuscular development.Alternative splicing results in RET isoforms with distinct trafficking properties.Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons.GDNF and addiction.Traditional and targeted exome sequencing reveals common, rare and novel functional deleterious variants in RET-signaling complex in a cohort of living US patients with urinary tract malformations.GDNF--a potential target to treat addiction.Neurotrophic factor receptor RET: structure, cell biology, and inherited diseases.CD2AP and Cbl-3/Cbl-c constitute a critical checkpoint in the regulation of ret signal transduction.Glial cell line-derived neurotrophic factor (GDNF) induces neuritogenesis in the cochlear spiral ganglion via neural cell adhesion molecule (NCAM)Identification of a novel partner gene, KIAA1217, fused to RET: Functional characterization and inhibitor sensitivity of two isoforms in lung adenocarcinomaRet function in muscle stem cells points to tyrosine kinase inhibitor therapy for facioscapulohumeral muscular dystrophy.Splicing variants impact in thyroid normal physiology and pathological conditions.Differential recruitment of E3-ubiquitin ligase complexes regulates RET isoform internalization.Exon Skipping in the RET Gene Encodes Novel Isoforms That Differentially Regulate RET Protein Signal Transduction.Distinct Temporal Regulation of RET Isoform Internalization: Roles of Clathrin and AP2.Retrograde transport of neurotrophic factor signaling: implications in neuronal development and pathogenesis.GM1 ganglioside enhances Ret signaling in striatum.Cellular localization of GDNF and its GFRalpha1/RET receptor complex in the developing pancreas of cat.Deciphering adaptor specificity in GFL-dependent RET-mediated proliferation and neurite outgrowth.NGF augments the autophosphorylation of Ret via inhibition of ubiquitin-dependent degradation.Evaluation of potential mechanisms underlying genotype-phenotype correlations in multiple endocrine neoplasia type 2.Glial cell line-derived neurotrophic factor-induced signaling in Schwann cells.Rescue of human RET gene expression by sodium butyrate: a novel powerful tool for molecular studies in Hirschsprung diseaseCritical and distinct roles for key RET tyrosine docking sites in renal development.Cell signalling and gene expression mediated by RET tyrosine kinase.
P2860
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P2860
The long and short isoforms of Ret function as independent signaling complexes.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
The long and short isoforms of Ret function as independent signaling complexes.
@en
type
label
The long and short isoforms of Ret function as independent signaling complexes.
@en
prefLabel
The long and short isoforms of Ret function as independent signaling complexes.
@en
P2093
P2860
P356
P1476
The long and short isoforms of Ret function as independent signaling complexes
@en
P2093
Brian A Tsui-Pierchala
Eugene M Johnson
Rebecca C Ahrens
Robert J Crowder
P2860
P304
34618-34625
P356
10.1074/JBC.M203580200
P407
P577
2002-06-28T00:00:00Z