Cell-cycle arrest by PD184352 requires inhibition of extracellular signal-regulated kinases (ERK) 1/2 but not ERK5/BMK1.
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MEK inhibitor U0126 reverses protection of axons from Wallerian degeneration independently of MEK-ERK signalingExtracellular signal-regulated kinases phosphorylate mitogen-activated protein kinase phosphatase 3/DUSP6 at serines 159 and 197, two sites critical for its proteasomal degradationExtracellular signal-regulated kinase 1/2 activity is not required in mammalian cells during late G2 for timely entry into or exit from mitosisA positive feedback loop involving Erk5 and Akt turns on mesangial cell proliferation in response to PDGF.ERK5 signalling in prostate cancer promotes an invasive phenotype.Clarithromycin delays progression of bronchial epithelial cells from G1 phase to S phase and delays cell growth via extracellular signal-regulated protein kinase suppressionSignal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention.ANGPTL3 is a novel biomarker as it activates ERK/MAPK pathway in oral cancer.ERK activity and G1 phase progression: identifying dispensable versus essential activities and primary versus secondary targetsNeuroprotective effects of 17β-estradiol rely on estrogen receptor membrane initiated signals.Acidosis promotes Bcl-2 family-mediated evasion of apoptosis: involvement of acid-sensing G protein-coupled receptor Gpr65 signaling to Mek/Erk.MAPK signalling: ERK5 versus ERK1/2.Estradiol-17beta-induced human neural progenitor cell proliferation is mediated by an estrogen receptor beta-phosphorylated extracellularly regulated kinase pathwayButyrate Inhibits Cancerous HCT116 Colon Cell Proliferation but to a Lesser Extent in Noncancerous NCM460 Colon Cells.Tumor cells with KRAS or BRAF mutations or ERK5/MAPK7 amplification are not addicted to ERK5 activity for cell proliferation.Grifolin exhibits anti-cancer activity by inhibiting the development and invasion of gastric tumor cells.Gram negative bacteria increase non-small cell lung cancer metastasis via Toll-like receptor 4 activation and mitogen-activated protein kinase phosphorylation.Oncogenic signaling of MEK5-ERK5.Fluid shear stress inhibits TNF-mediated JNK activation via MEK5-BMK1 in endothelial cellsThe effect of SYT-SSX and extracellular signal-regulated kinase (ERK) on cell proliferation in synovial sarcoma.Cyclic AMP inhibits the proliferation of thyroid carcinoma cell lines through regulation of CDK4 phosphorylation.New small-molecule inhibitors of mitogen-activated protein kinase kinase.Selective inhibition of MEK1/2 reveals a differential requirement for ERK1/2 signalling in the regulation of HIF-1 in response to hypoxia and IGF-1.Differential regulation of angiotensin II-induced extracellular signal regulated kinase-1/2 and -5 in progressive glomerulonephritis.Quantitative single cell determination of ERK phosphorylation and regulation in relapsed and refractory primary acute myeloid leukemia.DeltaRaf-1:ER* bypasses the cyclic AMP block of extracellular signal-regulated kinase 1 and 2 activation but not CDK2 activation or cell cycle reentry.Extracellular signal-regulated kinases 1/2 are serum-stimulated "Bim(EL) kinases" that bind to the BH3-only protein Bim(EL) causing its phosphorylation and turnover.The MEK/ERK pathway acts upstream of NF kappa B1 (p50) homodimer activity and Bcl-2 expression in a murine B-cell lymphoma cell line. MEK inhibition restores radiation-induced apoptosis.Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim.Endothelin-1 promotes hypertrophic remodelling of cardiac myocytes by activating sustained signalling and transcription downstream of endothelin type A receptors.Activation of a PAK-MEK signalling pathway in malaria parasite-infected erythrocytes.Downmodulation of ERK protein kinase activity inhibits VEGF secretion by human myeloma cells and myeloma-induced angiogenesis.Molecular cross-talk between MEK1/2 and mTOR signaling during recovery of 293 cells from hypertonic stress.Characterization of the MEK5-ERK5 module in human neutrophils and its relationship to ERK1/ERK2 in the chemotactic response.Metabolic stress regulates ERK activity by controlling KSR-RAF heterodimerization.TGF-β1 promotes bovine mammary fibroblast proliferation through the ERK 1/2 signalling pathway.The MEK/ERK signalling cascade is required for sonic hedgehog signalling pathway-mediated enhancement of proliferation and inhibition of apoptosis in normal keratinocytes.ERK5 activation enhances mesangial cell viability and collagen matrix accumulation in rat progressive glomerulonephritis.A CRISPR screen identifies MAPK7 as a target for combination with MEK inhibition in KRAS mutant NSCLC.
P2860
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P2860
Cell-cycle arrest by PD184352 requires inhibition of extracellular signal-regulated kinases (ERK) 1/2 but not ERK5/BMK1.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Cell-cycle arrest by PD184352 ...... s (ERK) 1/2 but not ERK5/BMK1.
@en
type
label
Cell-cycle arrest by PD184352 ...... s (ERK) 1/2 but not ERK5/BMK1.
@en
prefLabel
Cell-cycle arrest by PD184352 ...... s (ERK) 1/2 but not ERK5/BMK1.
@en
P2093
P2860
P356
P1433
P1476
Cell-cycle arrest by PD184352 ...... s (ERK) 1/2 but not ERK5/BMK1.
@en
P2093
Matthew S Squires
Paula M Nixon
Simon J Cook
P2860
P304
P356
10.1042/BJ20020372
P407
P577
2002-09-01T00:00:00Z