Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system.
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Multidrug resistance proteins (MRPs/ABCCs) in cancer chemotherapy and genetic diseasesPhase II trial of oral aminopterin for adults and children with refractory acute leukemiaMultidrug Resistance Proteins (MRPs) and Cancer TherapyNanoscale drug delivery systems and the blood-brain barrierIn vivo response to methotrexate forecasts outcome of acute lymphoblastic leukemia and has a distinct gene expression profileGene expression changes associated with resistance to intravenous corticosteroid therapy in children with severe ulcerative colitisGenome Analysis of Osteosarcoma Progression Samples Identifies FGFR1 Overexpression as a Potential Treatment Target and CHM as a Candidate Tumor Suppressor GeneDeregulated hepatic metabolism exacerbates impaired testosterone production in Mrp4-deficient mice.Role of drug transporters and drug accumulation in the temporal acquisition of drug resistanceFolate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamicsXenobiotic, bile acid, and cholesterol transporters: function and regulation.Urinary coproporphyrin I/(I + III) ratio as a surrogate for MRP2 or other transporter activities involved in methotrexate clearance.The intestinal absorption of folates.The reduced folate carrier (RFC) is cytotoxic to cells under conditions of severe folate deprivation. RFC as a double edged sword in folate homeostasisATP-binding cassette efflux transporters in human placenta.Identification of reference genes in human myelomonocytic cells for gene expression studies in altered gravity.Increased susceptibility to methotrexate-induced toxicity in nonalcoholic steatohepatitis.Assessment of the role of renal organic anion transporters in drug-induced nephrotoxicity.Dual role of cAMP in the transcriptional regulation of multidrug resistance-associated protein 4 (MRP4) in pancreatic adenocarcinoma cell lines.The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugsTyrosine kinase inhibitors as modulators of ABC transporter-mediated drug resistance.Hypoxic Stress Induced by Hydralazine Leads to a Loss of Blood-Brain Barrier Integrity and an Increase in Efflux Transporter ActivityRenal xenobiotic transporters are differentially expressed in mice following cisplatin treatment.Prominent expression of xenobiotic efflux transporters in mouse extraembryonic fetal membranes compared with placenta.The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene.Involvement of Multiple Transporters-mediated Transports in Mizoribine and Methotrexate Pharmacokinetics.Pharmacogenetics in acute lymphoblastic leukemia.Hepatic basolateral efflux contributes significantly to rosuvastatin disposition II: characterization of hepatic elimination by basolateral, biliary, and metabolic clearance pathways in rat isolated perfused liver.Human immunodeficiency virus protease inhibitors interact with ATP binding cassette transporter 4/multidrug resistance protein 4: a basis for unanticipated enhanced cytotoxicity.Disruption of cAMP and prostaglandin E2 transport by multidrug resistance protein 4 deficiency alters cAMP-mediated signaling and nociceptive response.The effect of ABCG2 and ABCC4 on the pharmacokinetics of methotrexate in the brain.Multidrug resistance associated proteins in multidrug resistance.Cyclic nucleotide compartmentalization: contributions of phosphodiesterases and ATP-binding cassette transporters.Overcoming docetaxel resistance in prostate cancer: a perspective review.A functional study on polymorphism of the ATP-binding cassette transporter ABCG2: critical role of arginine-482 in methotrexate transport.Mechanism of active renal tubular efflux of tenofovir.Up-regulation of P-glycoprotein confers acquired resistance to 6-mercaptopurine in human chronic myeloid leukemia cells.Quantitative Evaluation of Drug Resistance Profile of Cells Expressing Wild-Type or Genetic Polymorphic Variants of the Human ABC Transporter ABCC4.Brain efflux index to investigate the influence of active efflux on brain distribution of pemetrexed and methotrexate.Inhibition of PDE5A1 guanosine cyclic monophosphate (cGMP) hydrolysing activity by sildenafil analogues that inhibit cellular cGMP efflux
P2860
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P2860
Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
Analysis of methotrexate and f ...... he methotrexate efflux system.
@en
type
label
Analysis of methotrexate and f ...... he methotrexate efflux system.
@en
prefLabel
Analysis of methotrexate and f ...... he methotrexate efflux system.
@en
P2093
P1433
P1476
Analysis of methotrexate and f ...... the methotrexate efflux system
@en
P2093
Gary D Kruh
Michihiko Kuwano
Rebecca Blanchard Raftogianis
Susan Walther
Zhe-Sheng Chen
P304
P407
P577
2002-06-01T00:00:00Z