Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway. - Wikidata - awgldk - TriplyDB

Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway.

Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway.

http://www.wikidata.org/entity/Q40729554

about

Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition Insulin activates vascular endothelial growth factor in vascular smooth muscle cells: influence of nitric oxide and of insulin resistance Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation Signaling by target of rapamycin proteins in cell growth control Gut mucosal healing: is the science relevant?Insulin Is a Key Modulator of Fetoplacental Endothelium Metabolic Disturbances in Gestational Diabetes Mellitus Hypoxia-Inducible Histone Lysine Demethylases: Impact on the Aging Process and Age-Related Diseases Hypoxia-Inducible Factors (HIFs) and Phosphorylation: Impact on Stability, Localization, and Transactivity Reactive oxygen species, nutrition, hypoxia and diseases: Problems solved?HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans Putative Key Role of Inositol Messengers in Endothelial Cells in Preeclampsia mTOR and cancer therapy Hypoxia-inducible factors in the kidney Insulin induces REDD1 expression through hypoxia-inducible factor 1 activation in adipocytes A novel inhibitor of hypoxia-inducible factor-1α P3155 also modulates PI3K pathway and inhibits growth of prostate cancer cells An antagonism between the AKT and beta-adrenergic signaling pathways mediated through their reciprocal effects on miR-199a-5p Hypoxia-inducible factor-1α protein negatively regulates load-induced bone formation Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis ERK1/2 regulates intracellular ATP levels through alpha-enolase expression in cardiomyocytes exposed to ischemic hypoxia and reoxygenation HIF hydroxylation and cellular oxygen sensing.TOR signaling.Unsupervised clustering of gene expression data points at hypoxia as possible trigger for metabolic syndrome.A vascular piece in the puzzle of adipose tissue dysfunction: mechanisms and consequences.Phase I study of the mTOR inhibitor ridaforolimus and the HDAC inhibitor vorinostat in advanced renal cell carcinoma and other solid tumors.Identification of a novel small molecule HIF-1alpha translation inhibitor.Inhibition of hypoxia-inducible factor-1alpha (HIF-1alpha) protein synthesis by DNA damage inducing agents Antivascular therapy for epithelial ovarian cancer.Hypoxia-inducible factor-1 as a therapeutic target in endometrial cancer management Inhibition of cancer cell proliferation and metastasis by insulin receptor downregulation Myricetin inhibits UVB-induced angiogenesis by regulating PI-3 kinase in vivo.mTORC2 activity in brain cancer: Extracellular nutrients are required to maintain oncogenic signaling.Beyond oxygen: complex regulation and activity of hypoxia inducible factors in pregnancy.Natural product-derived small molecule activators of hypoxia-inducible factor-1 (HIF-1)Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury Epidermal growth factor receptor regulates aberrant expression of insulin-like growth factor-binding protein 3 Rapamycin inhibits VEGF-induced microvascular hyperpermeability in vivo.Detection of the onset of ischemia and carcinogenesis by hypoxia-inducible transcription factor-based in vivo bioluminescence imaging Toxoplasma gondii activates hypoxia-inducible factor (HIF) by stabilizing the HIF-1alpha subunit via type I activin-like receptor kinase receptor signaling.PI4KIIalpha is a novel regulator of tumor growth by its action on angiogenesis and HIF-1alpha regulation.

P2860

Q24301382-72D19B99-2F14-41E0-A285-9F2410F30C25 Q24306665-C5D8D4E8-2EB7-4A65-BE89-A044DC9C331E Q24323121-4183ACB8-9800-4ED9-A8E5-1655FF2CD5D3 Q24522447-E0B32B98-A04F-411C-AAFA-A55003978391 Q24669693-49C2E2A3-7D4F-4055-A2D1-C7F4C461A139 Q26749697-A04C59C3-5471-49BF-A258-4F1C38CDC448 Q26750099-A9EBFBD5-5E76-484B-9A5D-7694AAD7A08D Q26768230-4AFA797E-C897-4707-ADD5-E98BF3A36A6B Q26784413-4332D0CC-FE22-4783-B37E-AFB7906E447C Q27312348-6F07BEA4-778D-41EC-8436-3443AB7841F5 Q28080015-7801CA25-590A-402E-9ADD-1D11AB62EC1A Q28268516-291B9D2B-76B4-4B69-9514-3EB8A9B48FF0 Q28303287-CED39BE9-365E-47D4-A8C3-8F2A227B0770 Q28393534-0441F8AB-3BA5-4091-B59D-D03C184FB095 Q28394160-7137BA7F-B4DD-4EC6-A08B-24DCDB7EAC39 Q28566847-A3DB0C17-528A-412A-9214-01512B18D118 Q28585802-07381ABF-987E-4439-A9FD-45E6F507D5F8 Q28591503-C3DCE4A2-7E48-43B6-A5E0-FB431C56867A Q28728348-F7D9CFF7-4865-4F19-A94A-75EBFC235ED9 Q28909786-695B7A95-C524-4D86-A6E6-52C72FA6A7B6 Q30164092-6A5C69BA-994C-42B9-90C0-9300E878D930 Q30312086-EF893083-902A-4BA3-B0A2-BF17669578B1 Q30478807-CB0460C8-51D1-4BE8-BEA4-BCE58D4CE97C Q33356605-594F30AD-4742-4413-9565-47DFDCA5A7A6 Q33423777-42A9AA83-518F-40C0-B036-4C0A39C415EB Q33507488-A3DC4A1D-A8D4-44FE-98CB-DAC343F611A6 Q33580209-473D2D08-EEEC-4620-ABB8-8CF5B7986470 Q33583598-0BEB129D-7212-45D7-8060-F086DF9B9F90 Q33652379-4F821CC7-CD33-4912-8757-642F3EB24BF8 Q33818935-02076EAB-4667-4F89-A48E-81682D08A1C9 Q33829163-7B1F6BB3-49E8-42B0-A617-88CDCD89A47A Q33884658-4B801CC0-ECD5-4155-86B2-FA7B24387B5D Q33894600-007E990B-A88A-4B10-BFB8-4C486E2AB87C Q34009713-A1CDE1CF-EED9-49E8-B569-24CA89CDC8F4 Q34066937-24A77CF2-D35D-4168-966C-307234EBD020 Q34073234-DE74055F-7E9F-41FC-9B4E-CC2F0D80ED9E Q34078704-1EE34842-735A-4FE8-BA48-631DA4A9C9F7 Q34079232-ED28DA81-960C-46A4-9AAD-99E6E0F3ECD9 Q34094330-5C7BCAB6-4EA0-4EC6-AF6A-4BCCAE9D93DD Q34098706-DAFB7D2A-AFF6-4AF5-B4F9-BE735E92D28E

P2860

Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway.

http://www.wikidata.org/entity/Q40729554

description

2002 nî lūn-bûn

@nan

2002年の論文

@ja

2002年学术文章

@wuu

2002年学术文章

@zh-cn

2002年学术文章

@zh-hans

2002年学术文章

@zh-my

2002年学术文章

@zh-sg

2002年學術文章

@yue

2002年學術文章

@zh

2002年學術文章

@zh-hant

name

Insulin stimulates hypoxia-ind ...... n-dependent signaling pathway.

@en

type

label

Insulin stimulates hypoxia-ind ...... n-dependent signaling pathway.

@en

prefLabel

Insulin stimulates hypoxia-ind ...... n-dependent signaling pathway.

@en

P1433

Q40729554-4226027C-2C50-4901-BD6C-E38F8C69EF88

P1476

Q40729554-93BDE25C-4CD1-4D0C-982C-A806A654FBFB

P2093

Q40729554-2BF854B8-170B-47B7-B505-4E4535B165B4

Q40729554-4160EA95-8197-45FF-9764-E8CEAAB7CE85

Q40729554-95869ED5-DE72-4F9B-BF1F-BE7745C7A9A9

Q40729554-D8691F5F-3424-4203-9331-A8ACE79C995C

P2860

Q40729554-1966A5D1-ED21-4EE1-AAE7-59CF7108B962

Q40729554-218306CB-91D6-4559-9E63-0582550EA856

Q40729554-2B7943CE-0566-4CC4-AA7C-9046D86DF678

Q40729554-365518B7-38E2-46B8-A51F-8E4E21C092BD

Q40729554-3CF65547-CF8A-4A47-85B7-5AD6777ADAC4

Q40729554-3E5DF4DF-7826-4EB2-A51F-6CE8CB150787

Q40729554-3F03F3CE-1114-428E-87E7-40E581E02904

Q40729554-44EF84B9-07F5-47DB-BE2E-93120F486462

Q40729554-550AEDA4-EFB5-4EC7-A373-CE9BE494BC96

Q40729554-6364A0E2-E834-4B20-B4D3-911FFB1DB6DE

P304

Q40729554-4F5CCF3B-BBB6-4C35-BCF4-725727105354

P31

Q40729554-7CB2F1D4-D3D6-45EA-9A7A-7CCC682C9520

P356

Q40729554-A883041F-7C7A-4AC5-A7CA-55647966E342

P407

Q40729554-716794A0-79EC-45BB-8A60-369DB2144857

P433

Q40729554-E55F32EC-EF40-402B-92C4-6C326FC25818

P478

Q40729554-82FF3136-4FA3-4404-80CB-5B9F9116105B

P50

Q40729554-3EB27892-5185-42CA-81FA-92BACBA06AEC

P577

Q40729554-F8AC0B71-7710-4576-8C34-6D9CDF56CD11

P698

Q40729554-E90A2090-E5FA-43EF-9AD8-A4D784500F93

P921

Q40729554-297C7ED5-A4BC-465D-9BB4-2B1B5127D0E5

Q40729554-5D221A22-FB60-4325-8700-48999A0E170A

P356

P1433

Journal of Biological Chemistry

P1476

Insulin stimulates hypoxia-ind ...... n-dependent signaling pathway.

@en

P2093

Caroline Treins

http://www.w3.org/2001/XMLSchema#string

Emmanuel Van Obberghen

http://www.w3.org/2001/XMLSchema#string

Joseph Murdaca

http://www.w3.org/2001/XMLSchema#string

Sophie Giorgetti-Peraldi

http://www.w3.org/2001/XMLSchema#string

P2860

Insulin signalling and the regulation of glucose and lipid metabolism

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

HIF-1: mediator of physiological and pathophysiological responses to hypoxia

Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension

Regulation of eukaryotic initiation factor eIF2B: glycogen synthase kinase-3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin

Requirement for Akt (protein kinase B) in insulin-induced activation of glycogen synthase and phosphorylation of 4E-BP1 (PHAS-1)

P304

27975-27981

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1074/JBC.M204152200

http://www.w3.org/2001/XMLSchema#string

P407

P433

31

http://www.w3.org/2001/XMLSchema#string

P478

277

http://www.w3.org/2001/XMLSchema#string

P50

Gregg L. Semenza

P577

2002-05-24T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

12032158

http://www.w3.org/2001/XMLSchema#string

P921