The immune modulator FTY720 targets sphingosine 1-phosphate receptors. - Wikidata - awgldk - TriplyDB

The immune modulator FTY720 targets sphingosine 1-phosphate receptors.

The immune modulator FTY720 targets sphingosine 1-phosphate receptors.

http://www.wikidata.org/entity/Q40736684

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A single amino acid determines preference between phospholipids and reveals length restriction for activation of the S1P4 receptor Systematic identification of regulatory proteins critical for T-cell activation Fingolimod for relapsing-remitting multiple sclerosis Fingolimod for relapsing remitting multiple sclerosis Sphingosine 1-phosphate as a regulator of osteoclast differentiation and osteoclast-osteoblast coupling PTEN as an effector in the signaling of antimigratory G protein-coupled receptor Oral ponesimod in relapsing-remitting multiple sclerosis: a randomised phase II trial FTY720 story. Its discovery and the following accelerated development of sphingosine 1-phosphate receptor agonists as immunomodulators based on reverse pharmacology A defect of sphingolipid metabolism modifies the properties of normal appearing white matter in multiple sclerosis Targeting protein serine/threonine phosphatases for drug development A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors The emerging role of FTY720 (Fingolimod) in cancer treatment Fingolimod for multiple sclerosis and emerging indications: appropriate patient selection, safety precautions, and special considerations Sphingosine 1-phosphate receptor modulators in multiple sclerosis Integrating the puzzle pieces: the current atomistic picture of phospholipid-G protein coupled receptor interactions Sphingosine-1-phosphate in chronic intestinal inflammation and cancer Sphingosine 1-phosphate signalling Lysophospholipids and their receptors in the central nervous system Benefits versus risks of latest therapies in multiple sclerosis: a perspective review A review of ceramide analogs as potential anticancer agents Multiple sclerosis: the role of cytokines in pathogenesis and in therapies Fingolimod: direct CNS effects of sphingosine 1-phosphate (S1P) receptor modulation and implications in multiple sclerosis therapy Sphingosine-1-phosphate receptor 1 signalling in T cells: trafficking and beyond Fingolimod for the treatment of neurological diseases-state of play and future perspectives FTY720 treatment in the convalescence period improves functional recovery and reduces reactive astrogliosis in photothrombotic stroke Lysophospholipid receptors in drug discovery.SLI1 (YGR212W) is a major gene conferring resistance to the sphingolipid biosynthesis inhibitor ISP-1, and encodes an ISP-1 N-acetyltransferase in yeast Fingolimod Associated Bilateral Cystoid Macular Edema-Wait and See?The Direct Effects of Fingolimod in the Central Nervous System: Implications for Relapsing Multiple Sclerosis Exit Strategies: S1P Signaling and T Cell Migration Sphingosine-1-phosphate suppresses TLR-induced CXCL8 secretion from human T cells FTY720, an immunomodulatory sphingolipid mimetic: translation of a novel mechanism into clinical benefit in multiple sclerosis Development of oral immunomodulatory agents in the management of multiple sclerosis FTY720 protects cardiac microvessels of diabetes: a critical role of S1P1/3 in diabetic heart disease Disparate in vivo efficacy of FTY720 in xenograft models of Philadelphia positive and negative B-lineage acute lymphoblastic leukemia The clinically-tested S1P receptor agonists, FTY720 and BAF312, demonstrate subtype-specific bradycardia (S1P₁) and hypertension (S1P₃) in rat Fingolimod phosphate attenuates oligomeric amyloid β-induced neurotoxicity via increased brain-derived neurotrophic factor expression in neurons The Sphingosine-1-phospate receptor 1 mediates S1P action during cardiac development Identification of sphingolipid metabolites that induce obesity via misregulation of appetite, caloric intake and fat storage in Drosophila

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P2860

The immune modulator FTY720 targets sphingosine 1-phosphate receptors.

http://www.wikidata.org/entity/Q40736684

description

2002 nî lūn-bûn

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2002年の論文

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年學術文章

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2002年學術文章

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2002年學術文章

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name

The immune modulator FTY720 targets sphingosine 1-phosphate receptors.

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type

label

The immune modulator FTY720 targets sphingosine 1-phosphate receptors.

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prefLabel

The immune modulator FTY720 targets sphingosine 1-phosphate receptors.

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Journal of Biological Chemistry

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The immune modulator FTY720 targets sphingosine 1-phosphate receptors.

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P2093

Carolyn A Foster

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Christian Bruns

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Christopher E Heise

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Eva Prieschl

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Kevin R Lynch

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Markus Zollinger

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Michael D Davis

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Peter Hiestand

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Rainer Albert

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Robert Hof

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21453-21457

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scholarly article

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10.1074/JBC.C200176200

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24

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277

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11967257

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