about
Fused in sarcoma (FUS) interacts with the cytolinker protein plectin: implications for FUS subcellular localization and functionTorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeletonBPAG1 isoform-b: complex distribution pattern in striated and heart muscle and association with plectin and alpha-actininPlectin isoform 1-dependent nuclear docking of desmin networks affects myonuclear architecture and expression of mechanotransducers.Targeted proteolysis of plectin isoform 1a accounts for hemidesmosome dysfunction in mice mimicking the dominant skin blistering disease EBS-OgnaA site-specific plectin mutation causes dominant epidermolysis bullosa simplex Ogna: two identical de novo mutationsMicrotubule-associated protein 1A (MAP1A) and MAP1B: light chains determine distinct functional propertiesActin-binding domain of mouse plectin. Crystal structure and binding to vimentinThe many faces of plectin and plectinopathies: pathology and mechanismsEpiplakin deficiency aggravates murine caerulein-induced acute pancreatitis and favors the formation of acinar keratin granulesEpiplakin attenuates experimental mouse liver injury by chaperoning keratin reorganizationEpiplakin gene analysis in mouse reveals a single exon encoding a 725-kDa protein with expression restricted to epithelial tissuesDirect binding of plectin to Fer kinase and negative regulation of its catalytic activityStress-induced recruitment of epiplakin to keratin networks increases their resistance to hyperphosphorylation-induced disruptionIntermediate filament-associated cytolinker plectin 1c destabilizes microtubules in keratinocytesPlectin reinforces vascular integrity by mediating crosstalk between the vimentin and the actin networks.Unexpected gain of function for the scaffolding protein plectin due to mislocalization in pancreatic cancer.Targeted ablation of plectin isoform 1 uncovers role of cytolinker proteins in leukocyte recruitment.Plectin-controlled keratin cytoarchitecture affects MAP kinases involved in cellular stress response and migration.Plectin isoform 1b mediates mitochondrion-intermediate filament network linkage and controls organelle shape.Chemical chaperone ameliorates pathological protein aggregation in plectin-deficient muscle.Neuromuscular synapse integrity requires linkage of acetylcholine receptors to postsynaptic intermediate filament networks via rapsyn-plectin 1f complexes.FIP-2, an IkappaB-kinase-gamma-related protein, is associated with the Golgi apparatus and translocates to the marginal band during chicken erythroblast differentiation.Ferritin associates with marginal band microtubules.Rapid microwave fixation of cell monolayers preserves microtubule-associated cell structures.High-pressure freezing and low-temperature fixation of cell monolayers grown on sapphire coverslips.Trichoplein/mitostatin regulates endoplasmic reticulum-mitochondria juxtaposition.Determining the mechanical properties of plectin in mouse myoblasts and keratinocytes.Plectin regulates the organization of glial fibrillary acidic protein in Alexander disease.Keratins Stabilize Hemidesmosomes through Regulation of β4-Integrin Turnover.Plectin isoform P1b and P1d deficiencies differentially affect mitochondrial morphology and function in skeletal muscle.Linking cytoarchitecture to metabolism: sarcolemma-associated plectin affects glucose uptake by destabilizing microtubule networks in mdx myofibers.Plectin gene defects lead to various forms of epidermolysis bullosa simplex.Plectin isoforms as organizers of intermediate filament cytoarchitecture.Plectin-intermediate filament partnership in skin, skeletal muscle, and peripheral nerve.Networking and anchoring through plectin: a key to IF functionality and mechanotransduction.Molecular architecture and function of the hemidesmosome.Molecular architecture and function of the hemidesmosome.Vimentin intermediate filament and plectin provide a scaffold for invadopodia, facilitating cancer cell invasion and extravasation for metastasis.Silencing GFAP isoforms in astrocytoma cells disturbs laminin-dependent motility and cell adhesion.
P50
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P50
description
onderzoeker
@nl
name
Gerhard Wiche
@ast
Gerhard Wiche
@en
Gerhard Wiche
@es
Gerhard Wiche
@sl
type
label
Gerhard Wiche
@ast
Gerhard Wiche
@en
Gerhard Wiche
@es
Gerhard Wiche
@sl
prefLabel
Gerhard Wiche
@ast
Gerhard Wiche
@en
Gerhard Wiche
@es
Gerhard Wiche
@sl