Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion.
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Human CD57+ germinal center-T cells are the major helpers for GC-B cells and induce class switch recombinationPrediction of novel families of enzymes involved in oxidative and other complex modifications of bases in nucleic acidsOptimal functional levels of activation-induced deaminase specifically require the Hsp40 DnaJa1Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1Somatic hypermutation of the AID transgene in B and non-B cellsSMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repairThe structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1Functional redundancy between DNA ligases I and III in DNA replication in vertebrate cellsHuman activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminationsActivation-induced cytidine deaminase initiates immunoglobulin gene conversion and hypermutation by a common intermediateExpression of human AID in yeast induces mutations in context similar to the context of somatic hypermutation at G-C pairs in immunoglobulin genesGenetic manipulation of an exogenous non-immunoglobulin protein by gene conversion machinery in a chicken B cell lineAlternative Okazaki Fragment Ligation Pathway by DNA Ligase IIIRelated Mechanisms of Antibody Somatic Hypermutation and Class Switch RecombinationKu70 corrupts DNA repair in the absence of the Fanconi anemia pathwaySimultaneous disruption of two DNA polymerases, Polη and Polζ, in Avian DT40 cells unmasks the role of Polη in cellular response to various DNA lesionsDNA ligases I and III cooperate in alternative non-homologous end-joining in vertebratesThe interaction between AID and CIB1 is nonessential for antibody gene diversification by gene conversion or class switch recombinationTemporal regulation of Ig gene diversification revealed by single-cell imaging.Regulation of the DNA damage response and gene expression by the Dot1L histone methyltransferase and the 53Bp1 tumour suppressorRapid generation of specific antibodies by enhanced homologous recombination.A role for PCNA ubiquitination in immunoglobulin hypermutation.DNA-dependent protein kinase inhibits AID-induced antibody gene conversion.Chromatin structure regulates gene conversion.Activation-induced deaminase, AID, is catalytically active as a monomer on single-stranded DNA.Genetic variation stimulated by epigenetic modification.A cis-acting diversification activator both necessary and sufficient for AID-mediated hypermutation.Genetic evidence for single-strand lesions initiating Nbs1-dependent homologous recombination in diversification of Ig v in chicken B lymphocytes.RAD51 paralogs promote homology-directed repair at diversifying immunoglobulin V regionsFanconi anemia protein FANCD2 promotes immunoglobulin gene conversion and DNA repair through a mechanism related to homologous recombination.Functions and regulation of the APOBEC family of proteinsThe BRCT domain of PARP-1 is required for immunoglobulin gene conversion.Attracting AID to targets of somatic hypermutation.DNA cleavage in immunoglobulin somatic hypermutation depends on de novo protein synthesis but not on uracil DNA glycosylaseInduction of homologous recombination between sequence repeats by the activation induced cytidine deaminase (AID) proteinClassical Mus musculus Igκ enhancers support transcription but not high level somatic hypermutation from a V-lambda promoter in chicken DT40 cells.Tumor suppressor RecQL5 controls recombination induced by DNA crosslinking agentsA target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expressionAID and somatic hypermutation.Activation-induced deaminase cloning, localization, and protein extraction from young VH-mutant rabbit appendix.
P2860
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P2860
Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Requirement of the activation- ...... mmunoglobulin gene conversion.
@en
type
label
Requirement of the activation- ...... mmunoglobulin gene conversion.
@en
prefLabel
Requirement of the activation- ...... mmunoglobulin gene conversion.
@en
P2093
P356
P1433
P1476
Requirement of the activation- ...... mmunoglobulin gene conversion.
@en
P2093
Hiroshi Arakawa
Jean-Marie Buerstedde
Jessica Hauschild
P304
P356
10.1126/SCIENCE.1067308
P407
P577
2002-02-01T00:00:00Z