A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression
about
Mutational hotspots in the TP53 gene and, possibly, other tumor suppressors evolve by positive selection.Activation-induced cytidine deaminase expression in CD4+ T cells is associated with a unique IL-10-producing subset that increases with ageAID and Apobec3G haphazard deamination and mutational diversityThe AID antibody diversification enzyme is regulated by protein kinase A phosphorylation.Attracting AID to targets of somatic hypermutation.The cytidine deaminases AID and APOBEC-1 exhibit distinct functional properties in a novel yeast selectable system.Negative regulation of activation-induced cytidine deaminase in B cellsThe zebrafish IgH locus contains multiple transcriptional regulatory regions.Targeting of somatic hypermutation.In vivo analysis of Aicda gene regulation: a critical balance between upstream enhancers and intronic silencers governs appropriate expression.AID to overcome the limitations of genomic information by introducing somatic DNA alterations.Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation.Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice.Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genesRAP80 protein is important for genomic stability and is required for stabilizing BRCA1-A complex at DNA damage sites in vivoChanges in 2'-deoxycytidine levels in various tissues of tumor-bearing miceAID to overcome the limitations of genomic information.Identification of murine B cell lines that undergo somatic hypermutation focused to A:T and G:C residues.Genomic Architecture may Influence Recurrent Chromosomal Translocation Frequency in the Igh Locus.How does DNA break during chromosomal translocations?Inflammation-mediated genomic instability: roles of activation-induced cytidine deaminase in carcinogenesis.Functions and Malfunctions of Mammalian DNA-Cytosine DeaminasesAPOBEC3B can impair genomic stability by inducing base substitutions in genomic DNA in human cells.Expression of activation-induced cytidine deaminase gene in B lymphocytes of patients with common variable immunodeficiency.Generation of diversity by somatic mutation in the Camelus dromedarius T-cell receptor gamma variable domains.A novel mouse model of hepatocarcinogenesis triggered by AID causing deleterious p53 mutations.A model of liver carcinogenesis originating from hepatic progenitor cells with accumulation of genetic alterations.
P2860
Q25257243-1E7889E6-D998-4038-BC8D-DF3279B8F9A0Q28740775-2B2983EB-C34D-4226-B8BD-0953BA2A685DQ30537745-7D778E91-615F-4FB6-A16C-157B27F367CDQ33226024-EA2FFB93-E9AF-4888-AD7B-E82BE0E7F539Q33656131-72D8B62A-4F0C-4DFF-9E26-A16B21649B14Q34195827-D4BAD0F6-42D7-4140-A54F-6DD5874FCEE9Q34479651-00F2F514-04E9-4A40-816C-0F51ED813D7BQ34543109-4F5112FD-46AD-4441-B0AC-B1E3510C73F6Q34551108-28C3790D-3ECD-49CB-8482-3F2799C990CEQ34684380-F5098D31-3176-4C41-9A85-941414CFD849Q35068183-ACDAA61B-1D00-46E3-9E61-F1E97B98D447Q35585876-C22A6AA8-5CA3-41D9-A021-4C4660D98FC6Q35616311-519B9940-519B-470C-993B-2C4318CBA8FCQ35786869-D1BBD18A-1925-40D0-BE82-A37EAC561CFBQ36080420-A3DF7045-7A78-4609-A5E6-2A5643A70A97Q36142361-2FF3E234-F3A2-4252-8186-7776175CFB06Q36170796-FA95D1BA-22F9-4B33-A9F3-0C1A60BDC96AQ37164431-B328DD23-DFFA-4BF9-B55B-630F7D1B3EB6Q37417907-0C0A7D95-88CC-4BC7-81B4-95551CAAA6DAQ37865973-1409BEFF-5798-4D8D-9D5B-8CF81C60C9AFQ37999121-722592A2-490D-4F2C-90A8-CC3DA094ABA7Q38943944-9C0770A2-19C1-4A9C-B99A-DD7387639624Q39245074-983E8F7B-1D55-4BEC-976C-ACF0C71829F0Q41855727-6314717E-D579-4A5F-ADBB-D22247BC2A29Q44668250-FE3FBCAE-803B-48F9-9FC0-D830BFBC738EQ46255308-89F9C7EA-1DC3-46C5-A477-5364FE4363C5Q53250439-3D901A8A-E211-4C04-A96B-BBB4F03F20A7
P2860
A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression
description
2005 nî lūn-bûn
@nan
2005 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի մարտին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
A target selection of somatic ...... cytidine deaminase expression
@ast
A target selection of somatic ...... cytidine deaminase expression
@en
type
label
A target selection of somatic ...... cytidine deaminase expression
@ast
A target selection of somatic ...... cytidine deaminase expression
@en
prefLabel
A target selection of somatic ...... cytidine deaminase expression
@ast
A target selection of somatic ...... cytidine deaminase expression
@en
P2093
P2860
P50
P356
P1476
A target selection of somatic ...... cytidine deaminase expression
@en
P2093
Kazuo Kinoshita
Nasim A Begum
Toshiharu Nakajima
P2860
P304
P356
10.1073/PNAS.0500830102
P407
P577
2005-03-14T00:00:00Z