Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1. - Wikidata - awgldk - TriplyDB

Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1.

Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1.

http://www.wikidata.org/entity/Q40758558

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3-Phosphoinositide-dependent PDK1 negatively regulates transforming growth factor-beta-induced signaling in a kinase-dependent manner through physical interaction with Smad proteins Suppression of the mTOR-raptor signaling pathway by the inhibitor of heat shock protein 90 geldanamycin Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function 3-Phosphoinositide-dependent protein kinase-1-mediated IkappaB kinase beta (IkkB) phosphorylation activates NF-kappaB signaling Therapeutic Implications of Targeting AKT Signaling in Melanoma HSP27 is a ubiquitin-binding protein involved in I-kappaBalpha proteasomal degradation Keep your heart in shape: molecular chaperone networks for treating heart disease Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3 Regulation of transforming growth factor-beta signaling and PDK1 kinase activity by physical interaction between PDK1 and serine-threonine kinase receptor-associated protein The role of checkpoint kinase 1 in sensitivity to topoisomerase I poisons Heat shock protein 90 positively regulates Chikungunya virus replication by stabilizing viral non-structural protein nsP2 during infection Hsp90 modulates the stability of MLKL and is required for TNF-induced necroptosis Targeting the phosphoinositide 3-kinase pathway in cancer Preclinical validation of AR42, a novel histone deacetylase inhibitor, as treatment for vestibular schwannomas.Evidence that hsp90 is involved in the altered interactions of Acanthamoeba castellanii variants with bacteria.Elucidating the CXCL12/CXCR4 signaling network in chronic lymphocytic leukemia through phosphoproteomics analysis Hsp90 and Hsp40/Erdj3 are required for the expression and anti-apoptotic function of KSHV K1 Regulation of Hsp90 ATPase activity by the co-chaperone Cdc37p/p50cdc37.PDK1 recruitment to the SHPS-1 signaling complex enhances insulin-like growth factor-i-stimulated AKT activation and vascular smooth muscle cell survival.The turn motif is a phosphorylation switch that regulates the binding of Hsp70 to protein kinase C.Rank-rank hypergeometric overlap: identification of statistically significant overlap between gene-expression signatures.Structure of an Hsp90-Cdc37-Cdk4 complex.A novel method for detecting intramolecular coevolution: adding a further dimension to selective constraints analyses.An increase in integrin-linked kinase non-canonically confers NF-κB-mediated growth advantages to gastric cancer cells by activating ERK1/2.Stabilization of phosphatidylinositol 4-kinase type IIbeta by interaction with Hsp90 Small molecule inhibitors in acute myeloid leukemia: from the bench to the clinic Multiple implications of 3-phosphoinositide-dependent protein kinase 1 in human cancer.Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm HSP90 supports tumor growth and angiogenesis through PRKD2 protein stabilization.Heat shock protein 90 inhibitor NVP-AUY922 exerts potent activity against adult T-cell leukemia-lymphoma cells.Heat-shock protein 90 alpha (HSP90α) modulates signaling pathways towards tolerance of oxidative stress and enhanced survival of hepatocytes of Mugil cephalus.Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal.Apoptosis, necrosis and cellular senescence: chaperone occupancy as a potential switch.Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks.Heat shock response and insulin-associated neurodegeneration.Heat shock protein-90 dampens and directs signaling stimulated by insulin-like growth factor-1 and insulin PDK1 protein phosphorylation at Thr354 by murine protein serine-threonine kinase 38 contributes to negative regulation of PDK1 protein activity EGFR-PI3K-AKT-mTOR signaling in head and neck squamous cell carcinomas: attractive targets for molecular-oriented therapy Proteomic approaches for studying chemoresistance in cancer.Direct and indirect involvement of microRNA-499 in clinical and experimental cardiomyopathy.

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P2860

Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1.

http://www.wikidata.org/entity/Q40758558

description

2002 nî lūn-bûn

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2002年の論文

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年學術文章

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2002年學術文章

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2002年學術文章

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name

Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1.

@en

type

label

Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1.

@en

prefLabel

Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1.

@en

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P1433

Journal of Biological Chemistry

P1476

Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1.

@en

P2093

Atsushi Ishida

http://www.w3.org/2001/XMLSchema#string

Naoya Fujita

http://www.w3.org/2001/XMLSchema#string

Saori Sato

http://www.w3.org/2001/XMLSchema#string

Takashi Tsuruo

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P2860

The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo

The PI3K-PDK1 connection: more than just a road to PKB

Modulation of Akt kinase activity by binding to Hsp90

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

Signalling through the lipid products of phosphoinositide-3-OH kinase

Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin

Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

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10346-10353

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scholarly article

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10.1074/JBC.M106736200

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12

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277

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2002-01-04T00:00:00Z

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11779851

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