Inactivation of transcription factor gene ACE2 in the fungal pathogen Candida glabrata results in hypervirulence.
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The trans-kingdom identification of negative regulators of pathogen hypervirulenceGain of function mutations in CgPDR1 of Candida glabrata not only mediate antifungal resistance but also enhance virulenceOne small step for a yeast--microevolution within macrophages renders Candida glabrata hypervirulent due to a single point mutationTranscriptional Control of Drug Resistance, Virulence and Immune System Evasion in Pathogenic Fungi: A Cross-Species ComparisonSystematic phenotyping of a large-scale Candida glabrata deletion collection reveals novel antifungal tolerance genesDifferential virulence of Candida glabrata glycosylation mutantsNew insights into the structure of (1→3,1→6)-β-D-glucan side chains in the Candida glabrata cell wallRegulatory circuitry governing fungal development, drug resistance, and disease.Loss of mitochondrial functions associated with azole resistance in Candida glabrata results in enhanced virulence in miceDifferent consequences of ACE2 and SWI5 gene disruptions for virulence of pathogenic and nonpathogenic yeasts.Candida albicans transcription factor Ace2 regulates metabolism and is required for filamentation in hypoxic conditionsHosting infection: experimental models to assay Candida virulenceThe RAM network in pathogenic fungi.Facultative sterol uptake in an ergosterol-deficient clinical isolate of Candida glabrata harboring a missense mutation in ERG11 and exhibiting cross-resistance to azoles and amphotericin B.The Pneumocystis Ace2 transcription factor regulates cell wall-remodeling genes and organism virulence.The Aspergillus fumigatus transcription factor Ace2 governs pigment production, conidiation and virulence.A Small Protein Associated with Fungal Energy Metabolism Affects the Virulence of Cryptococcus neoformans in Mammals.Mutation of the regulator of G protein signaling Crg1 increases virulence in Cryptococcus neoformans.Candida albicans transcription factor Rim101 mediates pathogenic interactions through cell wall functions.Epigenetic regulation of the nitrosative stress response and intracellular macrophage survival by extraintestinal pathogenic Escherichia coli.Genome duplication and mutations in ACE2 cause multicellular, fast-sedimenting phenotypes in evolved Saccharomyces cerevisiae.From Saccharomyces cerevisiae to Candida glabratain a few easy steps: important adaptations for an opportunistic pathogen.Candida glabrata: a deadly companion?Candida glabrata environmental stress response involves Saccharomyces cerevisiae Msn2/4 orthologous transcription factors.Intracellular survival of Candida glabrata in macrophages: immune evasion and persistence.Evolution of regulatory networks in Candida glabrata: learning to live with the human host.Novel Agents and Drug Targets to Meet the Challenges of Resistant Fungi.Toll-like receptors (TLRs) expression and function in response to inactivate hyphae of Fusarium solani in immortalized human corneal epithelial cells.Cytotoxic and cytokine-inducing properties of Candida glabrata in single and mixed oral infection models.The high-osmolarity glycerol response pathway in the human fungal pathogen Candida glabrata strain ATCC 2001 lacks a signaling branch that operates in baker's yeast.Amino acid-derived 1,2-benzisothiazolinone derivatives as novel small-molecule antifungal inhibitors: identification of potential genetic targets.Pathogenesis and Antifungal Drug Resistance of the Human Fungal Pathogen Candida glabrata.Deletion of ADA2 increases antifungal drug susceptibility and virulence in Candida glabrata.Transcription regulation of the alpha-glucanase gene agn1 by cell separation transcription factor Ace2p in fission yeast.
P2860
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P2860
Inactivation of transcription factor gene ACE2 in the fungal pathogen Candida glabrata results in hypervirulence.
description
2004 nî lūn-bûn
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2004年の論文
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2004年学术文章
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2004年学术文章
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name
Inactivation of transcription ...... ata results in hypervirulence.
@en
type
label
Inactivation of transcription ...... ata results in hypervirulence.
@en
prefLabel
Inactivation of transcription ...... ata results in hypervirulence.
@en
P2093
P2860
P50
P1433
P1476
Inactivation of transcription ...... ata results in hypervirulence.
@en
P2093
Ana-Maria Calcagno
Elaine Bignell
Fritz A Mühlschlegel
Helen Findon
Ken Haynes
Michael D Jones
Mohammed Kamran
Peter Warn
Philip Hopkins
P2860
P304
P356
10.1128/EC.3.2.546-552.2004
P577
2004-04-01T00:00:00Z