Characterization of a pediatric T-cell acute lymphoblastic leukemia patient with simultaneous LYL1 and LMO2 rearrangements.
about
The LMO2 oncogene regulates DNA replication in hematopoietic cellsUse of single nucleotide polymorphism array technology to improve the identification of chromosomal lesions in leukemiaImmature MEF2C-dysregulated T-cell leukemia patients have an early T-cell precursor acute lymphoblastic leukemia gene signature and typically have non-rearranged T-cell receptors.SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cellsGFI1B, EVI5, MYB--additional genes that cooperate with the human BCL6 gene to promote the development of lymphomasMetabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia.Clinical significance of high c-MYC and low MYCBP2 expression and their association with Ikaros dysfunction in adult acute lymphoblastic leukemiaIntracellular Signaling Pathways Involved in Childhood Acute Lymphoblastic Leukemia; Molecular TargetsTargeting High Dynamin-2 (DNM2) Expression by Restoring Ikaros Function in Acute Lymphoblastic Leukemia.Breakpoint sites disclose the role of the V(D)J recombination machinery in the formation of T-cell receptor (TCR) and non-TCR associated aberrations in T-cell acute lymphoblastic leukemia.Extreme hyperleukocytosis in a pediatric T-ALL patient with a rare translocation, t(7;19)(q35;p13), and submicroscopic deletions at 4q25, 7q33 and 10q23.Development of safer gene delivery systems to minimize the risk of insertional mutagenesis-related malignancies: a critical issue for the field of gene therapy.Genetic and epigenetic studies offer new therapeutic options for the treatment of T-cell acute lymphoblastic leukemia.Plant homeodomain finger protein 2 as a novel IKAROS target in acute lymphoblastic leukemia.MEF2C phosphorylation is required for chemotherapy resistance in acute myeloid leukemia.Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling.Aberrant ARID5B expression and its association with Ikaros dysfunction in acute lymphoblastic leukemia
P2860
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P2860
Characterization of a pediatric T-cell acute lymphoblastic leukemia patient with simultaneous LYL1 and LMO2 rearrangements.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh
2011年學術文章
@zh-hant
name
Characterization of a pediatri ...... LYL1 and LMO2 rearrangements.
@en
type
label
Characterization of a pediatri ...... LYL1 and LMO2 rearrangements.
@en
prefLabel
Characterization of a pediatri ...... LYL1 and LMO2 rearrangements.
@en
P2093
P2860
P1433
P1476
Characterization of a pediatri ...... LYL1 and LMO2 rearrangements.
@en
P2093
Anton W Langerak
Irene Homminga
Jessica Buijs-Gladdines
Jules P P Meijerink
Maartje J Vuerhard
P2860
P304
P356
10.3324/HAEMATOL.2011.051722
P50
P577
2011-11-04T00:00:00Z