ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo.
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Targeting the MEK1 cascade in lung epithelium inhibits proliferation and fibrogenesis by asbestosReprogramming of lysosomal gene expression by interleukin-4 and Stat6A possible anti-inflammatory role of angiotensin II type 2 receptor in immune-mediated glomerulonephritis during type 1 receptor blockade.The absence of interleukin-6 enhanced arsenite-induced renal injury by promoting autophagy of tubular epithelial cells with aberrant extracellular signal-regulated kinase activation.Interleukin-13 directly promotes oesophagus production of CCL11 and CCL24 and the migration of eosinophils.Establishment of extracellular signal-regulated kinase 1/2 bistability and sustained activation through Sprouty 2 and its relevance for epithelial function.Utilization of gene profiling and proteomics to determine mineral pathogenicity in a human mesothelial cell line (LP9/TERT-1).MiR-375 is downregulated in epithelial cells after IL-13 stimulation and regulates an IL-13-induced epithelial transcriptome.An essential regulatory role of downstream of kinase-1 in the ovalbumin-induced murine model of asthma.Cathepsin E promotes pulmonary emphysema via mitochondrial fission.IL-13 promotes collagen accumulation in Crohn's disease fibrosis by down-regulation of fibroblast MMP synthesis: a role for innate lymphoid cells?Adenosine metabolism and murine strain-specific IL-4-induced inflammation, emphysema, and fibrosis.Monocyte 15-lipoxygenase gene expression requires ERK1/2 MAPK activity.Mitogen-activated protein kinase signalling and ERK1/2 bistability in asthma.Chitinase 1 is a biomarker for and therapeutic target in scleroderma-associated interstitial lung disease that augments TGF-β1 signaling.Obligatory role for interleukin-13 in obstructive lesion development in airway allografts.Prenatal secondhand cigarette smoke promotes Th2 polarization and impairs goblet cell differentiation and airway mucus formation.Asbestos-induced peribronchiolar cell proliferation and cytokine production are attenuated in lungs of protein kinase C-delta knockout mice.G Protein βγ-subunit signaling mediates airway hyperresponsiveness and inflammation in allergic asthma.Toll-like receptor stimulation differentially regulates vasoactive intestinal peptide type 2 receptor in macrophages.HIV Impairs Lung Epithelial Integrity and Enters the Epithelium to Promote Chronic Lung Inflammation.SPLUNC1 deficiency enhances airway eosinophilic inflammation in mice.Immunogenetic programs for viral induction of mucous cell metaplasiaIL-9 and IL-13 induce mucous cell metaplasia that is reduced by IFN-gamma in a Bax-mediated pathway.Pharmacological blockade of A2A receptors prevents dermal fibrosis in a model of elevated tissue adenosineGenome-Wide Methylation Study Identifies an IL-13-induced Epigenetic Signature in Asthmatic Airways.Acute lung injury and cell death: how many ways can cells die?How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer?Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthmaLung vascular endothelial growth factor expression induces local myeloid dendritic cell activation.IL-13/STAT6 signaling plays a critical role in the epithelial-mesenchymal transition of colorectal cancer cells.Chitinase 3-like 1 regulates cellular and tissue responses via IL-13 receptor α2beta-Adrenoceptor inverse agonists in asthmaCross-roads in the lung: immune cells and tissue interactions as determinants of allergic asthma.Toll-like receptor 4 deficiency causes pulmonary emphysema.The role of STIM1 in the Cr(vi)-induced [Ca(2+)]i increase and cell injury in L-02 hepatocytes.Chronic allergic pulmonary inflammation is aggravated in angiotensin-(1-7) Mas receptor knockout mice.Pathobiology of cigarette smoke-induced chronic obstructive pulmonary disease.Integrin beta4 attenuates SHP-2 and MAPK signaling and reduces human lung endothelial inflammatory responses.Hepatocyte growth factor inhibits epithelial to myofibroblast transition in lung cells via Smad7.
P2860
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P2860
ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
ERK1/2 mitogen-activated prote ...... mation and remodeling in vivo.
@en
type
label
ERK1/2 mitogen-activated prote ...... mation and remodeling in vivo.
@en
prefLabel
ERK1/2 mitogen-activated prote ...... mation and remodeling in vivo.
@en
P2093
P2860
P356
P1476
ERK1/2 mitogen-activated prote ...... mation and remodeling in vivo.
@en
P2093
Brooke T Mossman
Jack A Elias
Mercedes Rincon
Patty J Lee
Peiying Shan
Xuchen Zhang
P2860
P304
P356
10.1172/JCI25711
P407
P577
2005-12-22T00:00:00Z