The first transmembrane segment of the dopamine D2 receptor: accessibility in the binding-site crevice and position in the transmembrane bundle.
about
Dopamine D2 receptors form higher order oligomers at physiological expression levelsStructure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective AntagonistPrediction of the burial status of transmembrane residues of helical membrane proteins.Homology model of the CB1 cannabinoid receptor: sites critical for nonclassical cannabinoid agonist interaction.The crystallographic model of rhodopsin and its use in studies of other G protein-coupled receptors.What can crystal structures of aminergic receptors tell us about designing subtype-selective ligands?N-(3-fluoro-4-(4-(2-methoxy or 2,3-dichlorophenyl)piperazine-1-yl)butyl)arylcarboxamides as selective dopamine D3 receptor ligands: critical role of the carboxamide linker for D3 receptor selectivity.The second extracellular loop of the dopamine D2 receptor lines the binding-site crevice.The predicted 3D structure of the human D2 dopamine receptor and the binding site and binding affinities for agonists and antagonists.A single glycine in extracellular loop 1 is the critical determinant for pharmacological specificity of dopamine D2 and D3 receptors.Two intracellular helices of G-protein coupling receptors could generally support oligomerization and coupling with transducers.Modeling and protein engineering studies of active and inactive states of human dopamine D2 receptor (D2R) and investigation of drug/receptor interactions.Involvement of the first transmembrane segment of human α(2) -adrenoceptors in the subtype-selective binding of chlorpromazine, spiperone and spiroxatrine.Helix 8 plays a crucial role in bradykinin B(2) receptor trafficking and signaling.Differential helical orientations among related G protein-coupled receptors provide a novel mechanism for selectivity. Studies with salvinorin A and the kappa-opioid receptor.1-Methylpyridinium-4-(4-phenylmethanethiosulfonate) iodide, MTS-MPP+, a novel scanning cysteine accessibility method (SCAM) reagent for monoamine transporter studies.
P2860
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P2860
The first transmembrane segment of the dopamine D2 receptor: accessibility in the binding-site crevice and position in the transmembrane bundle.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
The first transmembrane segmen ...... n in the transmembrane bundle.
@en
type
label
The first transmembrane segmen ...... n in the transmembrane bundle.
@en
prefLabel
The first transmembrane segmen ...... n in the transmembrane bundle.
@en
P2093
P356
P1433
P1476
The first transmembrane segmen ...... n in the transmembrane bundle.
@en
P2093
Ballesteros JA
Javitch JA
Simpson MM
P304
12339-12348
P356
10.1021/BI011204A
P407
P577
2001-10-01T00:00:00Z