PAR-6 regulates aPKC activity in a novel way and mediates cell-cell contact-induced formation of the epithelial junctional complex.
about
Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6The MAGUK protein MPP7 binds to the polarity protein hDlg1 and facilitates epithelial tight junction formationNucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activityComprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein networkKv7.1 surface expression is regulated by epithelial cell polarizationThe cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM)Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localizationProtein kinase C iota: human oncogene, prognostic marker and therapeutic targetBrain endothelial cell-cell junctions: how to "open" the blood brain barrierPolarity in mammalian epithelial morphogenesisThe alternative splicing factor Nova2 regulates vascular development and lumen formation.An aPKC-exocyst complex controls paxillin phosphorylation and migration through localised JNK1 activationThe carboxyl terminus of zona occludens-3 binds and recruits a mammalian homologue of discs lost to tight junctionsLoss of aPKCĪ» in differentiated neurons disrupts the polarity complex but does not induce obvious neuronal loss or disorientation in mouse brainsLoss of partitioning-defective-3/isotype-specific interacting protein (par-3/ASIP) in the elongating spermatid of RA175 (IGSF4A/SynCAM)-deficient miceJAM-C regulates tight junctions and integrin-mediated cell adhesion and migrationAssociation of ASIP/mPAR-3 with adherens junctions of mouse neuroepithelial cellsE-cadherin is essential for in vivo epidermal barrier function by regulating tight junctionsThe interdependence of the Rho GTPases and apicobasal cell polarity.Loss of Par3 promotes breast cancer metastasis by compromising cell-cell cohesion.Signaling pathways in cell polarity.The NF2 tumor suppressor, Merlin, regulates epidermal development through the establishment of a junctional polarity complex.Tuba, a Cdc42 GEF, is required for polarized spindle orientation during epithelial cyst formation.The PAR proteins: fundamental players in animal cell polarization.The Par3/aPKC interaction is essential for end bud remodeling and progenitor differentiation during mammary gland morphogenesis.Widely conserved signaling pathways in the establishment of cell polarityDifferent domains of C. elegans PAR-3 are required at different times in development.Cell polarity regulator PARD6B is essential for trophectoderm formation in the preimplantation mouse embryo.Par6B and atypical PKC regulate mitotic spindle orientation during epithelial morphogenesisPolarity proteins and cell-cell interactions in the testis.Cdc42 regulates apical junction formation in human bronchial epithelial cells through PAK4 and Par6BBinding to PKC-3, but not to PAR-3 or to a conventional PDZ domain ligand, is required for PAR-6 function in C. elegansEstablishment of epithelial polarity--GEF who's minding the GAP?Evidence for a functional interaction between cingulin and ZO-1 in cultured cells.The polarity protein Par6 induces cell proliferation and is overexpressed in breast cancer.Myosin 5b loss of function leads to defects in polarized signaling: implication for microvillus inclusion disease pathogenesis and treatment.Establishing cell polarity in development.An overview of C. Elegans trafficking mutants.Meningococcal type IV pili recruit the polarity complex to cross the brain endothelium.Protein complexes that control renal epithelial polarity.
P2860
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P2860
PAR-6 regulates aPKC activity in a novel way and mediates cell-cell contact-induced formation of the epithelial junctional complex.
description
2001 nĆ® lÅ«n-bĆ»n
@nan
2001幓ć®č«ę
@ja
2001幓å¦ęÆęē«
@wuu
2001幓å¦ęÆęē«
@zh-cn
2001幓å¦ęÆęē«
@zh-hans
2001幓å¦ęÆęē«
@zh-my
2001幓å¦ęÆęē«
@zh-sg
2001幓åøč”ęē«
@yue
2001幓åøč”ęē«
@zh
2001幓åøč”ęē«
@zh-hant
name
PAR-6 regulates aPKC activity ...... epithelial junctional complex.
@en
type
label
PAR-6 regulates aPKC activity ...... epithelial junctional complex.
@en
prefLabel
PAR-6 regulates aPKC activity ...... epithelial junctional complex.
@en
P2093
P2860
P1433
P1476
PAR-6 regulates aPKC activity ...... epithelial junctional complex
@en
P2093
A Yamashita
H Ishikawa
K Kitamura
T Yamanaka
Y Horikoshi
Y Sugiyama
P2860
P304
P356
10.1046/J.1365-2443.2001.00453.X
P577
2001-08-01T00:00:00Z