Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6.
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Activation and allosteric modulation of a muscarinic acetylcholine receptorCharacterization of an orphan G protein-coupled receptor, GPR20, that constitutively activates Gi proteinsPotential modes of interaction of 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives with the 5-HT2A receptor: a ligand structure-affinity relationship, receptor mutagenesis and receptor modeling investigationMolecular basis for negative regulation of the glucagon receptorIdentification of two distinct inactive conformations of the beta2-adrenergic receptor reconciles structural and biochemical observationsStructure-based design, synthesis, and biochemical and pharmacological characterization of novel salvinorin A analogues as active state probes of the kappa-opioid receptorSingle-cell analysis of G-protein signal transductionStructure of a beta1-adrenergic G-protein-coupled receptor.Structural biology of human cannabinoid receptor-2 helix 6 in membrane-mimetic environmentsStructure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective AntagonistTwo distinct conformations of helix 6 observed in antagonist-bound structures of a 1-adrenergic receptorEvidence for Follicle-stimulating Hormone Receptor as a Functional TrimerUnderstanding functional residues of the cannabinoid CB1.Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexantTransmembrane signal transduction by peptide hormones via family B G protein-coupled receptorsIdentification of duplicated fourth alpha2-adrenergic receptor subtype by cloning and mapping of five receptor genes in zebrafishA functional selectivity mechanism at the serotonin-2A GPCR involves ligand-dependent conformations of intracellular loop 2Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptorNew mechanism for voltage induced charge movement revealed in GPCRs--theory and experimentsMolecular dynamics simulation studies of GLUT4: substrate-free and substrate-induced dynamics and ATP-mediated glucose transport inhibitionSmall molecules with similar structures exhibit agonist, neutral antagonist or inverse agonist activity toward angiotensin II type 1 receptorHomology modeling of dopamine D2 and D3 receptors: molecular dynamics refinement and docking evaluationA dynamic view of molecular switch behavior at serotonin receptors: implications for functional selectivityTM2-TM7 interaction in coupling movement of transmembrane helices to activation of the angiotensin II type-1 receptorMutagenesis analysis of the serotonin 5-HT2C receptor and a Caenorhabditis elegans 5-HT2 homologue: conserved residues of helix 4 and helix 7 contribute to agonist-dependent activation of 5-HT2 receptorsDeterminants involved in subtype-specific functions of rat trace amine-associated receptors 1 and 4Beyond small-molecule SAR: using the dopamine D3 receptor crystal structure to guide drug designThe structure and function of G-protein-coupled receptorsMolecular dynamics simulations of rhodopsin point mutants at the cytoplasmic side of helices 3 and 6.The role of experimental and computational structural approaches in 7TM drug discovery.Unraveling the structure and function of G protein-coupled receptors through NMR spectroscopy.Exploring the mechanism of F282L mutation-caused constitutive activity of GPCR by a computational study.Dissimilar interaction of CB1/CB2 with lipid bilayers as revealed by molecular dynamics simulation.Simulations of biased agonists in the β(2) adrenergic receptor with accelerated molecular dynamics.Structure-based simulations reveal concerted dynamics of GPCR activationCloning and characterization of the pheromone biosynthesis activating neuropeptide receptor from the silkmoth, Bombyx mori. Significance of the carboxyl terminus in receptor internalization.High affinity agonistic metal ion binding sites within the melanocortin 4 receptor illustrate conformational change of transmembrane region 3.Forced unbinding of GPR17 ligands from wild type and R255I mutant receptor models through a computational approach.Principles and determinants of G-protein coupling by the rhodopsin-like thyrotropin receptor.An evolutionarily conserved arginine is essential for Tre1 G protein-coupled receptor function during germ cell migration in Drosophila melanogaster
P2860
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P2860
Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Activation of the beta 2-adren ...... ransmembrane segments 3 and 6.
@en
type
label
Activation of the beta 2-adren ...... ransmembrane segments 3 and 6.
@en
prefLabel
Activation of the beta 2-adren ...... ransmembrane segments 3 and 6.
@en
P2093
P2860
P356
P1476
Activation of the beta 2-adren ...... ransmembrane segments 3 and 6.
@en
P2093
A D Jensen
G Liapakis
J A Ballesteros
J A Javitch
S G Rasmussen
P2860
P304
29171-29177
P356
10.1074/JBC.M103747200
P407
P50
P577
2001-05-25T00:00:00Z