The role of conserved tryptophan and acidic residues in the human dopamine transporter as characterized by site-directed mutagenesis.
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Defining the blanks--pharmacochaperoning of SLC6 transporters and ABC transportersNonclassical pharmacology of the dopamine transporter: atypical inhibitors, allosteric modulators, and partial substratesRole of the dopamine transporter in the action of psychostimulants, nicotine, and other drugs of abuseRecognition of psychostimulants, antidepressants, and other inhibitors of synaptic neurotransmitter uptake by the plasma membrane monoamine transportersThe atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitorsGlycosyl modification facilitates homo- and hetero-oligomerization of the serotonin transporter. A specific role for sialic acid residuesClassic Studies on the Interaction of Cocaine and the Dopamine TransporterAssessing the ability of sequence-based methods to provide functional insight within membrane integral proteins: a case study analyzing the neurotransmitter/Na+ symporter family.The N terminus of monoamine transporters is a lever required for the action of amphetaminesGeneration of an activating Zn(2+) switch in the dopamine transporter: mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle.Interrelation of dopamine transporter oligomerization and surface presence as studied with mutant transporter proteins and amphetamine.Computational and biochemical docking of the irreversible cocaine analog RTI 82 directly demonstrates ligand positioning in the dopamine transporter central substrate-binding site.Mutational analysis of the high-affinity zinc binding site validates a refined human dopamine transporter homology modelSite-directed mutations near transmembrane domain 1 alter conformation and function of norepinephrine and dopamine transportersInteraction of cocaine-, benztropine-, and GBR12909-like compounds with wild-type and mutant human dopamine transporters: molecular features that differentially determine antagonist-binding properties.Dopamine transporter oligomerization: impact of combining protomers with differential cocaine analog binding affinitiesImportance of cholesterol in dopamine transporter function.Interaction of catechol and non-catechol substrates with externally or internally facing dopamine transporters.A Markov State-based Quantitative Kinetic Model of Sodium Release from the Dopamine Transporter.Dopamine Transporter Amino and Carboxyl Termini Synergistically Contribute to Substrate and Inhibitor Affinities.Impact of disruption of secondary binding site S2 on dopamine transporter function.Bivalent phenethylamines as novel dopamine transporter inhibitors: evidence for multiple substrate-binding sites in a single transporter.Substrates and inhibitors display different sensitivity to expression level of the dopamine transporter in heterologously expressing cells.The conserved glutamate (Glu136) in transmembrane domain 2 of the serotonin transporter is required for the conformational switch in the transport cycle.Mutation of Trp84 and Asp313 of the dopamine transporter reveals similar mode of binding interaction for GBR12909 and benztropine as opposed to cocaine.Interaction between dopamine and its transporter: role of intracellular sodium ions and membrane potential.The role of N-glycosylation in function and surface trafficking of the human dopamine transporter.Aspartate 345 of the dopamine transporter is critical for conformational changes in substrate translocation and cocaine binding.Cationic interactions at the human dopamine transporter reveal binding conformations for dopamine distinguishable from those for the cocaine analog 2 alpha-carbomethoxy-3 alpha-(4-fluorophenyl)tropane.Human dopamine transporter gene variation: effects of protein coding variants V55A and V382A on expression and uptake activities.Identification of intracellular residues in the dopamine transporter critical for regulation of transporter conformation and cocaine binding.Latch and trigger role for R445 in DAT transport explains molecular basis of DTDS.Localization of cocaine analog [125I]RTI 82 irreversible binding to transmembrane domain 6 of the dopamine transporter.Small molecule induced oligomerization, clustering and clathrin-independent endocytosis of the dopamine transporter.Dopamine transporter oligomerization involves the scaffold domain, but spares the bundle domain.
P2860
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P2860
The role of conserved tryptophan and acidic residues in the human dopamine transporter as characterized by site-directed mutagenesis.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
The role of conserved tryptoph ...... by site-directed mutagenesis.
@en
type
label
The role of conserved tryptoph ...... by site-directed mutagenesis.
@en
prefLabel
The role of conserved tryptoph ...... by site-directed mutagenesis.
@en
P2093
P2860
P1476
The role of conserved tryptoph ...... by site-directed mutagenesis.
@en
P2093
P2860
P304
P356
10.1046/J.1471-4159.2001.00312.X
P407
P577
2001-05-01T00:00:00Z