Agrin-induced phosphorylation of the acetylcholine receptor regulates cytoskeletal anchoring and clustering.
about
A single pulse of agrin triggers a pathway that acts to cluster acetylcholine receptorsTo build a synapse: signaling pathways in neuromuscular junction assemblyDistinct retrieval and retention mechanisms are required for the quality control of endoplasmic reticulum protein folding.Acetylcholine receptors are required for agrin-induced clustering of postsynaptic proteins.The function of cortactin in the clustering of acetylcholine receptors at the vertebrate neuromuscular junctionAgrin regulates rapsyn interaction with surface acetylcholine receptors, and this underlies cytoskeletal anchoring and clusteringAgrin mediates a rapid switch from electrical coupling to chemical neurotransmission during synaptogenesisRapsyn carboxyl terminal domains mediate muscle specific kinase-induced phosphorylation of the muscle acetylcholine receptorAgrin regulates CLASP2-mediated capture of microtubules at the neuromuscular junction synaptic membrane.Neuromuscular synapse integrity requires linkage of acetylcholine receptors to postsynaptic intermediate filament networks via rapsyn-plectin 1f complexes.The function of Shp2 tyrosine phosphatase in the dispersal of acetylcholine receptor clusters.Partition profile of the nicotinic acetylcholine receptor in lipid domains upon reconstitutionNeuregulin induces the expression of transcription factors and myosin heavy chains typical of muscle spindles in cultured human muscle.Imaging T-cell antigen recognition and comparing immunological and neuronal synapses.Cholesterol and lipid microdomains stabilize the postsynapse at the neuromuscular junction.The nicotinic acetylcholine receptor gene family of the honey bee, Apis mellifera.Single, context-specific glycans can target misfolded glycoproteins for ER-associated degradationLaminin-1 redistributes postsynaptic proteins and requires rapsyn, tyrosine phosphorylation, and Src and Fyn to stably cluster acetylcholine receptors.Forced expression of muscle specific kinase slows postsynaptic acetylcholine receptor loss in a mouse model of MuSK myasthenia gravisDok-7 myasthenia: phenotypic and molecular genetic studies in 16 patients.Rapsyn interacts with the muscle acetylcholine receptor via alpha-helical domains in the alpha, beta, and epsilon subunit intracellular loops.Heat-shock proteins in clinical neurology.Serum levels of matrix metalloproteinases: implications in clinical neurology.MuSK glycosylation restrains MuSK activation and acetylcholine receptor clustering.The formation of complex acetylcholine receptor clusters requires MuSK kinase activity and structural information from the MuSK extracellular domain.Identification of a motif in the acetylcholine receptor beta subunit whose phosphorylation regulates rapsyn association and postsynaptic receptor localization.Smac/Diablo antagonizes ubiquitin ligase activity of inhibitor of apoptosis proteins.Ephexin1 is required for structural maturation and neurotransmission at the neuromuscular junction.Matrix metalloproteinase-3 in myasthenia gravis compared to other neurological disorders and healthy controls.The cys-loop ligand-gated ion channel gene superfamily of the parasitoid wasp, Nasonia vitripennis.Dual role for calcium in agrin signaling and acetylcholine receptor clustering.Regulation of acetylcholine receptor clustering by the tumor suppressor APC.Regulation of muscle acetylcholine receptor turnover by β subunit tyrosine phosphorylation.An extracellular pathway for dystroglycan function in acetylcholine receptor aggregation and laminin deposition in skeletal myotubes.Agrin-LRP4-MuSK signaling as a therapeutic target for myasthenia gravis and other neuromuscular disorders.Defective peripheral nerve myelination and neuromuscular junction formation in fukutin-deficient chimeric mice.Effects of aging and Parkinson's disease on motor unit remodeling: influence of resistance exercise training.Shp2 is dispensable in the formation and maintenance of the neuromuscular junction.Muscle-specific kinase (MuSK) autoantibodies suppress the MuSK pathway and ACh receptor retention at the mouse neuromuscular junction.Anti-voltage-gated potassium channel Kv1.4 antibodies in myasthenia gravis
P2860
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P2860
Agrin-induced phosphorylation of the acetylcholine receptor regulates cytoskeletal anchoring and clustering.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
Agrin-induced phosphorylation ...... etal anchoring and clustering.
@en
type
label
Agrin-induced phosphorylation ...... etal anchoring and clustering.
@en
prefLabel
Agrin-induced phosphorylation ...... etal anchoring and clustering.
@en
P2860
P356
P1476
Agrin-induced phosphorylation ...... etal anchoring and clustering.
@en
P2093
P2860
P356
10.1083/JCB.153.1.1
P407
P577
2001-04-01T00:00:00Z