Inhibition of the G2 DNA damage checkpoint and of protein kinases Chk1 and Chk2 by the marine sponge alkaloid debromohymenialdisine.
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Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchangeDNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of CancerGenotoxic anti-cancer agents and their relationship to DNA damage, mitosis, and checkpoint adaptation in proliferating cancer cellsStructure-based design, discovery and development of checkpoint kinase inhibitors as potential anticancer therapiesCrystal structure of checkpoint kinase 2 in complex with NSC 109555, a potent and selective inhibitorCellular inhibition of checkpoint kinase 2 (Chk2) and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 [7-nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide].Structural characterization of inhibitor complexes with checkpoint kinase 2 (Chk2), a drug target for cancer therapyScreen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signalingNitazoxanide stimulates autophagy and inhibits mTORC1 signaling and intracellular proliferation of Mycobacterium tuberculosisInhibitors of the influenza A virus M2 proton channel discovered using a high-throughput yeast growth restoration assayThe effects of G2-phase enrichment and checkpoint abrogation on low-dose hyper-radiosensitivityCloning and characterization of liver-specific isoform of Chk1 gene from ratQ28828244Oxaliplatin responses in colorectal cancer cells are modulated by CHK2 kinase inhibitors.Mechanism targeted discovery of antitumor marine natural products.Superaugmented eccentric distance sum connectivity indices: novel highly discriminating topological descriptors for QSAR/QSPR.Curcumin-induced mitotic arrest is characterized by spindle abnormalities, defects in chromosomal congression and DNA damage.Inhibition of autophagosome formation by the benzoporphyrin derivative verteporfin.ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling.Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signalingRegulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.TLR9 engagement on CD4 T lymphocytes represses gamma-radiation-induced apoptosis through activation of checkpoint kinase response elements.DNA-activated protein kinase functions in a newly observed S phase checkpoint that links histone mRNA abundance with DNA replication.The autophagy inhibitor verteporfin moderately enhances the antitumor activity of gemcitabine in a pancreatic ductal adenocarcinoma model.Marine pyrrolocarbazoles and analogues: synthesis and kinase inhibition.Alkaloids from the Sponge Stylissa carteri Present Prospective Scaffolds for the Inhibition of Human Immunodeficiency Virus 1 (HIV-1)Increased activity of CHK enhances the radioresistance of MCF-7 breast cancer stem cells.Regulation of Epstein-Barr virus origin of plasmid replication (OriP) by the S-phase checkpoint kinase Chk2.Oxidative stress induces a prolonged but reversible arrest in p53-null cancer cells, involving a Chk1-dependent G2 checkpoint.Characterization of a novel ATR-dependent, Chk1-independent, intra-S-phase checkpoint that suppresses initiation of replication in Xenopus.Marine Sponge Natural Products with Anticancer Potential: An Updated Review.G2 DNA damage checkpoint inhibition and antimitotic activity of 13-hydroxy-15-oxozoapatlin.Inhibition of Chk1-dependent G2 DNA damage checkpoint radiosensitizes p53 mutant human cells.Autophosphorylation of checkpoint kinase 2 at serine 516 is required for radiation-induced apoptosis.Docking-based 3D-QSAR study of pyridyl aminothiazole derivatives as checkpoint kinase 1 inhibitors.In silico structural and functional analysis of the human TOPK protein by structure modeling and molecular dynamics studies.
P2860
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P2860
Inhibition of the G2 DNA damage checkpoint and of protein kinases Chk1 and Chk2 by the marine sponge alkaloid debromohymenialdisine.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
Inhibition of the G2 DNA damag ...... lkaloid debromohymenialdisine.
@en
type
label
Inhibition of the G2 DNA damag ...... lkaloid debromohymenialdisine.
@en
prefLabel
Inhibition of the G2 DNA damag ...... lkaloid debromohymenialdisine.
@en
P2093
P2860
P356
P1476
Inhibition of the G2 DNA damag ...... alkaloid debromohymenialdisine
@en
P2093
A A Goodarzi
D E Williams
J R Hutchins
R J Andersen
S P Lees-Miller
P2860
P304
17914-17919
P356
10.1074/JBC.M100728200
P407
P577
2001-03-07T00:00:00Z