Characterization of a novel ATR-dependent, Chk1-independent, intra-S-phase checkpoint that suppresses initiation of replication in Xenopus.
about
A synthetic lethal screen identifies ATR-inhibition as a novel therapeutic approach for POLD1-deficient cancersA novel DNA damage response: rapid degradation of the p12 subunit of dna polymerase deltaGEMC1 is a TopBP1-interacting protein required for chromosomal DNA replicationThe effect of the intra-S-phase checkpoint on origins of replication in human cells.The effect of a DNA damaging agent on embryonic cell cycles of the cnidarian Hydractinia echinata.ATR activation and replication fork restart are defective in FANCM-deficient cells.The DNA unwinding element binding protein DUE-B interacts with Cdc45 in preinitiation complex formation.Rad17 plays a central role in establishment of the interaction between TopBP1 and the Rad9-Hus1-Rad1 complex at stalled replication forksContinued primer synthesis at stalled replication forks contributes to checkpoint activation.Fanconi anemia proteins are required to prevent accumulation of replication-associated DNA double-strand breaksMultifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes.ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaksThe functional role of Cdc6 in S-G2/M in mammalian cells.Tight Chk1 Levels Control Replication Cluster Activation in Xenopus.5-ASA affects cell cycle progression in colorectal cells by reversibly activating a replication checkpoint.Evidence for a mammalian late-G1 phase inhibitor of replication licensing distinct from geminin or Cdk activity.Role for Rif1 in the checkpoint response to damaged DNA in Xenopus egg extractsTipin is required for stalled replication forks to resume DNA replication after removal of aphidicolin in Xenopus egg extracts.Open sesame: activating dormant replication origins in the mouse immunoglobulin heavy chain (Igh) locusSUMO2/3 modification of cyclin E contributes to the control of replication origin firing.Repression of nascent strand elongation by deregulated Cdt1 during DNA replication in Xenopus egg extracts.DNA topoisomerase IIα controls replication origin cluster licensing and firing time in Xenopus egg extractsAnalyzing the ATR-mediated checkpoint using Xenopus egg extractsControl of DNA replication by the nucleus/cytoplasm ratio in Xenopus.TopBP1 and DNA polymerase-alpha directly recruit the 9-1-1 complex to stalled DNA replication forks.Divergent S phase checkpoint activation arising from prereplicative complex deficiency controls cell survival.A patient-derived-xenograft platform to study BRCA-deficient ovarian cancers.The Intra-S Checkpoint Responses to DNA Damage.Surviving chromosome replication: the many roles of the S-phase checkpoint pathway.The structure and polymerase-recognition mechanism of the crucial adaptor protein AND-1 in the human replisome.Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities.Interaction of Chk1 with Treslin negatively regulates the initiation of chromosomal DNA replication.The human oncoprotein MDM2 induces replication stress eliciting early intra-S-phase checkpoint response and inhibition of DNA replication origin firing.Temporal profiling of the chromatin proteome reveals system-wide responses to replication inhibitionXenopus Mcm10 is a CDK-substrate required for replication fork stability.Excess Mcm2-7 license dormant origins of replication that can be used under conditions of replicative stress.Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress.Cdt1 downregulation by proteolysis and geminin inhibition prevents DNA re-replication in XenopusXenopus Cdc7 executes its essential function early in S phase and is counteracted by checkpoint-regulated protein phosphatase 1.Clusters, factories and domains: The complex structure of S-phase comes into focus.
P2860
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P2860
Characterization of a novel ATR-dependent, Chk1-independent, intra-S-phase checkpoint that suppresses initiation of replication in Xenopus.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Characterization of a novel AT ...... ion of replication in Xenopus.
@en
type
label
Characterization of a novel AT ...... ion of replication in Xenopus.
@en
prefLabel
Characterization of a novel AT ...... ion of replication in Xenopus.
@en
P2093
P2860
P356
P1476
Characterization of a novel AT ...... ion of replication in Xenopus.
@en
P2093
J Julian Blow
M Gloria Luciani
Maren Oehlmann
P2860
P304
P356
10.1242/JCS.01400
P407
P577
2004-11-09T00:00:00Z