NSAID-based γ-secretase modulators do not bind to the amyloid-β polypeptide.
about
Structural Mechanism of the Interaction of Alzheimer Disease Aβ Fibrils with the Non-steroidal Anti-inflammatory Drug (NSAID) Sulindac SulfideThe quiet renaissance of protein nuclear magnetic resonance.Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseasesPresenilin is the molecular target of acidic γ-secretase modulators in living cells.A critique of the drug discovery and phase 3 clinical programs targeting the amyloid hypothesis for Alzheimer disease.Second generation γ-secretase modulators exhibit different modulation of Notch β and Aβ production.γ-Secretase modulator (GSM) photoaffinity probes reveal distinct allosteric binding sites on presenilin.Binding of longer Aβ to transmembrane domain 1 of presenilin 1 impacts on Aβ42 generationColloidal drug formulations can explain "bell-shaped" concentration-response curves.Intrinsically disordered proteins: from sequence and conformational properties toward drug discovery.Development and mechanism of γ-secretase modulators for Alzheimer's disease.Structural and biochemical differences between the Notch and the amyloid precursor protein transmembrane domains.Target of γ-secretase modulators, presenilin marks the spot.Competition between homodimerization and cholesterol binding to the C99 domain of the amyloid precursor protein.NSAIDs as potential treatment option for preventing amyloid β toxicity in Alzheimer's disease: an investigation by docking, molecular dynamics, and DFT studies.
P2860
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P2860
NSAID-based γ-secretase modulators do not bind to the amyloid-β polypeptide.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
NSAID-based γ-secretase modulators do not bind to the amyloid-β polypeptide.
@en
type
label
NSAID-based γ-secretase modulators do not bind to the amyloid-β polypeptide.
@en
prefLabel
NSAID-based γ-secretase modulators do not bind to the amyloid-β polypeptide.
@en
P2093
P2860
P356
P1433
P1476
NSAID-based γ-secretase modulators do not bind to the amyloid-β polypeptide.
@en
P2093
Charles R Sanders
John B Jordan
Klaus Michelsen
Paul J Barrett
Stephen A Kaufman
P2860
P304
10328-10342
P356
10.1021/BI201371J
P407
P577
2011-11-02T00:00:00Z